Category: 131803-48-0

Related Products of 131803-48-0, Adding some certain compound to certain chemical reactions, such as: 131803-48-0, name is Methyl 6-(bromomethyl)nicotinate,molecular formula is C8H8BrNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 131803-48-0.

NaH (60%, 41.5mg, 1 .O4mmol) was added to a solution of (3) (200mg, 0.99mmol) in DMF (lOmL) at 5C under N2(g). The reaction mixture was stirred for 20 mm then methyl 4-(bromomethyl)benzoate (294mg, 1 .29mmol) was added. The stirring was continued at 70C under N2(g) for lh. The reaction was cooled to rt and poured onto water (l5OmL) and brine (5OmL), the aqueous was extracted with EtOAc (3 xlOOmL). Combined organics were dried over Na2504, filtered and concentrated invacuo. The residue was purified by flash column chromatography withCH2CI2/EtOAc (1:0-0:1) then EtOAc/MeOH (1:0-4:1) to yield (4) (251mg, 73%).1H NMR (500 MHz, Chloroform-d), OH ppm: 8.06-8.10 (m, 2H), 7.87-7.92 (m, 3H),7.78 (d, J=1.5 Hz, 1H), 7.44 (d, J=8.4 Hz, 2H), 7.23 (dd, J=8.2, 1.4 Hz, 1H), 7.15(dd, J=8.1, 4.7 Hz, 1H), 5.42 (5, 2H), 3.85 (5, 3H), 3.73 (5, 3H). LCMS (ES): Found 350.9 [M+H].

According to the analysis of related databases, 131803-48-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KARUS THERAPEUTICS LTD; SHUTTLEWORTH, Stephen Joseph; TOMASSI, Cyrille Davy; CECIL, Alexander Richard Liam; MACCORMICK, Somhairle; NODES, William John; SILVA, Franck Alexandre; WO2014/181137; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.131803-48-0, name is Methyl 6-(bromomethyl)nicotinate, molecular formula is C8H8BrNO2, molecular weight is 230.06, as common compound, the synthetic route is as follows.category: pyridine-derivatives

NaH (60%, 48.5mg, 1.2lmmol) was added to a solution of (3) (200mg, 1.lSmmol) inDMF (7mL) at 5C under N2(g). The reaction mixture was stirred for 20mm thenmethyl 6-(bromomethyl)pyridine-3-carboxylate (345mg, 1 .Smmol) was added as asolution in DMF (3mL). The stirring was continued at 70C for lh. Reaction cooled toand poured onto water (lOOmL). Brine (25mL) was added and the aqueous wasextracted with EtOAc (2 x lOOmL). Combined organics were dried over Na25O4, filtered and concentrated in vacuo. The residue was purified by flash column chromatography with CH2CI2/EtOAc (1:0-0:1) then EtOAc/MeOH (1:0-4:1) to give (4) (129mg, 35%).1H NMR (500 MHz, Chloroform-d), OH ppm: 9.04-9.13 (m, 1H), 8.70 (5, 2H), 8.19 (5,2H), 8.13 (dd, J=5.6, 2.3 Hz, 3H), 7.32 (d, J=8.2 Hz, 1H), 5.55 (5, 2H), 3.86 (5, 3H). LCMS (ES): Found 322.9 [M+H].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,131803-48-0, Methyl 6-(bromomethyl)nicotinate, and friends who are interested can also refer to it.

Reference:
Patent; KARUS THERAPEUTICS LTD; SHUTTLEWORTH, Stephen Joseph; TOMASSI, Cyrille Davy; CECIL, Alexander Richard Liam; MACCORMICK, Somhairle; NODES, William John; SILVA, Franck Alexandre; WO2014/181137; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 131803-48-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 131803-48-0, name is Methyl 6-(bromomethyl)nicotinate, molecular formula is C8H8BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Methyl 6-(anilinomethyl)pyridine-3-carboxylate hydrochloride (I-30) A mixture of N-Boc-aniline (350 mg, 1.81 mmol) and methyl 6-(bromomethyl)pyridine-3-carboxylate (500 mg, 2.17 mmol) in THF (10 mL) at 0 C. was added with sodium hydride (108 mg, 60% dispersion in mineral oil, 2.71 mmol). The reaction was stirred for 1 h at room temperature was then heated at 60 C. for 5 h. The reaction was cooled to room temperature and quenched with water. The mixture was partitioned between ethyl acetate and saturated aqueous ammonium chloride solution. The organic phase was washed with brine, dried over MgSO4 then evaporated to dryness. The residue was taken up with 4N solution of HCl in dioxane (5.5 mL) and the resulting mixture was stirred at room temperature for 2 h. The reaction was concentrated under reduced pressure and the residue was triturated with diethyl ether to provide the title compound (394 mg, 78%) as an off-white solid. 1H NMR (400 MHz, DMSO): delta 9.07 (d, J=2.0 Hz, 1H), 8.33 (dd, J=2.0, 8.0 Hz, 1H), 7.59 (d, J=8.4 Hz, 1H), 7.14-7.10 (m, 2H), 6.74-6.70 (m, 3H), 4.54 (s, 2H), 3.88 (s, 3H), NH not observed.

According to the analysis of related databases, 131803-48-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; AMARI, Gabriele; ARMANI, Elisabetta; GHIDINI, Eleonora; BAKER-GLENN, Charles; VAN DE POEL, Herve; WHITTAKER, Ben; US2015/158858; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 131803-48-0 ,Some common heterocyclic compound, 131803-48-0, molecular formula is C8H8BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 4-ethyl-N-(3-fluorophenyl)piperazine- l-carboxamide (0.334 g, 1.330 mmol) and sodium hydride (60.00 %, 0.059 g, 1.463 mmol) in tetrahydrofuran (6 mL) was stirred at the room temperature for 30 min, and mixed with methyl 6-(bromomethyl)nicotinate (0.337 g, 1.463 mmol). The reaction mixture was stirred at the same temperature for additional 18 hr. Then, water was added to the reaction mixture, followed by extraction with dichloromethane. The bi-phasic mixture was passed through a plastic frit to remove the solid residues and aqueous layer, and the organic layer collected was concentrated in vacuo. The title compound was used without further purification (methyl 6-((4-ethyl-N-(3-fluorophenyl)piperazine- l-carboxamido)methyl)nicotinate, 0.530 g, 99.5 %, brown oil).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 131803-48-0, Methyl 6-(bromomethyl)nicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Jaekwang; KIM, Yuntae; LEE, Chang Sik; SONG, Hyeseung; GWAK, Dal-Yong; LEE, Jaeyoung; OH, Jung Taek; LEE, Chang Gon; KIM, II Hyang; (1041 pag.)WO2017/23133; (2017); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 131803-48-0, Methyl 6-(bromomethyl)nicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 131803-48-0, blongs to pyridine-derivatives compound. COA of Formula: C8H8BrNO2

Example II (0492) 6-{[Bis(pyrazin-2-yl)amino]methyl}-N-hydroxypyridine-3-carboxamide (0493) (0494) II (0495) NaH (60%, 48.5mg, 1.21 mmol) was added to a solution of (3) (200mg, 1.15mmol) in DMF (7ml_) at 5C under N2(g). The reaction mixture was stirred for 20min then methyl 6-(bromomethyl)pyridine-3-carboxylate (345mg, 1.5mmol) was added as a solution in DMF (3ml_). The stirring was continued at 70C for 1 h. Reaction cooled to rt and poured onto water (100ml_). Brine (25ml_) was added and the aqueous was extracted with EtOAc (2 x 100ml_). Combined organics were dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by flash column chromatography with CH2CI2/EtOAc (1 :0-0:1) then EtOAc/MeOH (1 :0-4: 1) to give (4) (129mg, 35%). (0496) 1 H NMR (500 MHz, Chloroform-d), deltaEta ppm: 9.04-9.13 (m, 1 H), 8.70 (s, 2H), 8.19 (s, 2H), 8.13 (dd, J=5.6, 2.3 Hz, 3H), 7.32 (d, J=8.2 Hz, 1 H), 5.55 (s, 2H), 3.86 (s, 3H). LCMS (ES): Found 322.9 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,131803-48-0, its application will become more common.

Reference:
Patent; KARUS THERAPEUTICS LTD; SHUTTLEWORTH, Stephen Joseph; WHALE, Andrew David; COLMAN, Lucy Mary; ROGERS, Helen Louise; (117 pag.)WO2017/208032; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 131803-48-0 ,Some common heterocyclic compound, 131803-48-0, molecular formula is C8H8BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of tert-butyl 4-(N-phenylsulfamoyl)piperazine-1-carboxylate (0.600 g, 1.757 mmol) in N,N-dimethylformide (10 mL) was slowly added sodium hydride (60.00 %, 0.091 g, 2.285 mmol) at the room temperature, and the mixture was stirred for 5 min at the same temperature. The reaction mixture was treated with methyl 6-(bromomethyl)nicotinate (0.485 g, 2.109 mmol), and stirred at the same temperature for additional 16 hr. Then, saturated aqueous sodium bicarbonate solution was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with aqueous saturated sodium chloride solution, dried with anhydrous MgSO4, filtered, and concentrated in vacuo. The residue was chromatographed (SiO2, 40 g cartridge; ethyl acetate / hexane = 10 % to 50 %) to give the crude product, which was dissolved in hexane (100 mL), and stirred. The resulting precipitates were collected by filtration, washed by hexane, and dried to give tert-butyl 4-(N-((5-(methoxycarbonyl)pyridin-2-yl)methyl)-N-phenylsulfamoyl)piperazine-1-carboxylate as white solid (0.585 g, 67.9 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 131803-48-0, Methyl 6-(bromomethyl)nicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Jaekwang; HAN, Younghue; KIM, Yuntae; MIN, Jaeki; BAE, Miseon; KIM, Dohoon; JIN, Seokmin; KYUNG, Jangbeen; (191 pag.)WO2017/18805; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem