Category: 132-20-7

On March 31, 2015, Kiraz, Hasan Ali; Oemuer, Dilek; Ekin, Serpil; Toman, Hueseyin; Uyan, Berna; Yurtlu, Buelent Serhan; Hanci, Volkan published an article.Formula: C20H24N2O4 The title of the article was Evaluation of precipitation characteristics of commonly used non-steroidal anti-inflammatory analgesic drugs. And the article contained the following:

Postoperative pain is a major problem in clin. practice. Non-steroidal anti-inflammatory drugs have traditionally been used to relieve postoperative pain. Administration of i.v. products together can result incompatibility problems and this is clin. hazardous. Reference texts, published reports can provide information about drugs’ incompatibility characteristics but there have been limited data for new drugs such as lornoxicam, tenoxicam and dexketoprofen, commonly used non-steroidal antiinflammatory drugs. In this study, it was aimed to investigate whether there is precipitation between lornoxicam, tenoxicam and dexketoprofen with other commonly used drugs in anesthesiol. practice. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Formula: C20H24N2O4

The Article related to tenoxicam dexketoprofen lornoxicam nonsteroidal antiinflammatory analgesic precipitation, Pharmaceuticals: Pharmaceutics and other aspects.Formula: C20H24N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Banda, Jagadeesh; Lakshmanan, Ramalingam; Vvs, Shiva Prasad; Gudla, Srinibas Patro; Prudhivi, Rosaiah published an article in 2015, the title of the article was A highly sensitive method for the quantification of fludrocortisone in human plasma using ultra-high-performance liquid chromatography tandem mass spectrometry and its pharmacokinetic application.Application of 132-20-7 And the article contains the following content:

A simple and high sensitive ultra-high-performance liquid chromatog. tandem mass spectrometry method for the determination of fludrocortisone in human plasma was developed and validated as per guidelines. The analyte and internal standard (IS), fludrocortisone-d5, were extracted from human plasma via liquid-liquid extraction using tert-Bu Me ether. The chromatog. separation was achieved on a Chromolith RP18e column using a mixture of acetonitrile and 2 mM ammonium formate (70:30, volume/volume) as the mobile phase at a flow rate of 0.7 mL/min. Quantitation was performed on a triple quadrupole mass spectrometer employing electrospray ionization technique, operating in multiple reaction monitoring and pos. ion mode. The precursors to product ion transitions monitored for fludrocortisone and IS were m/z 381.2 → 343.2 and 386.2 → 348.4, resp. The assay was validated with linear range of 40-3000 pg/mL. The intra- and inter-day precisions (relative standard deviation) were within 0.49-7.13 and 0.83-5.87%, resp. The proposed method was successfully applied to pharmacokinetic studies in humans. Copyright © 2015 John Wiley & Sons, Ltd. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application of 132-20-7

The Article related to fludrocortisone acetate plasma pharmacokinetics uhplc tandem mass spectrometry, uhplc-ms/ms, fludrocortisone, human plasma, method validation, pharmacokinetics, Pharmacology: Drug Metabolism and other aspects.Application of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shi, Peiying; Lin, Xinhua; Yao, Hong published an article in 2015, the title of the article was Metabolism and plasma pharmacokinetics of isoorientin, a natural active ingredient, in Sprague-Dawley male rats after oral and intravenous administration.Product Details of 132-20-7 And the article contains the following content:

Several pharmacol. effects have been revealed on isoorientin, suggesting its potential medicinal prospects. The metabolic and plasma pharmacokinetic profiles of isoorientin were investigated in rats. For intra-gastric gavage, parent drug and three metabolites were detected in urine and feces by HPLC-MS/MS, but only one metabolite was found in plasma and identified as isoorientin 3′- or 4′-O-sulfate (M1) according to MS and UV absorbance spectra. After a single i.v. administration of isoorientin (5, 10, or 15 mg/kg B.W.) in rats, linear pharmacokinetic property was observed with favorable terminal half-lives (1.67 ± 1.32-2.07 ± 0.50 h). After a single p.o. administration of isoorientin (150 mg/kg B.W.) in rats, plasma isoorientin concentration was low, but the concentration of M1 was comparatively high. Low systemic exposure of oral isoorientin in rats could result from its low aqueous solubility and extensive first-pass metabolism, and plasma concentration of M1 can be used as a biomarker of isoorientin intake. Isoorientin showed low oral bioavailability (8.98 ± 1.07%), and had about 6% or 45% dose recovery in urine or feces, resp., 72 h after intra-gastric gavage. These studies are the first to describe the pharmacokinetics of isoorientin via i.v. or p.o. dosing, providing important information for understanding its process in vivo. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Product Details of 132-20-7

The Article related to isoorientin metabolite pharmacokinetics oral intravenous drug delivery, isoorientin, metabolism, pharmacokinetics, Pharmacology: Drug Metabolism and other aspects.Product Details of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 31, 2011, Hu, Le-Le; Chen, Chen; Huang, Tao; Cai, Yu-Dong; Chou, Kuo-Chen published an article.HPLC of Formula: 132-20-7 The title of the article was Predicting biological functions of compounds based on chemical-chemical interactions. And the article contained the following:

Given a compound, how can we effectively predict its biol. function. It is a fundamentally important problem because the information thus obtained may benefit the understanding of many basic biol. processes and provide useful clues for drug design. In this study, based on the information of chem.-chem. interactions, a novel method was developed that can be used to identify which of the following eleven metabolic pathway classes a query compound may be involved with: (1) Carbohydrate Metabolism, (2) Energy Metabolism, (3) Lipid Metabolism, (4) Nucleotide Metabolism, (5) Amino Acid Metabolism, (6) Metabolism of Other Amino Acids, (7) Glycan Biosynthesis and Metabolism, (8) Metabolism of Cofactors and Vitamins, (9) Metabolism of Terpenoids and Polyketides, (10) Biosynthesis of Other Secondary Metabolites, (11) Xenobiotics Biodegradation and Metabolism It was observed that the overall success rate obtained by the method via the 5-fold cross-validation test on a benchmark dataset consisting of 3,137 compounds was 77.97%, which is much higher than 10.45%, the corresponding success rate obtained by the random guesses. Besides, to deal with the situation that some compounds may be involved with more than one metabolic pathway class, the method presented here is featured by the capacity able to provide a series of potential metabolic pathway classes ranked according to the descending order of their likelihood for each of the query compounds concerned. Furthermore, our method was also applied to predict 5,549 compounds whose metabolic pathway classes are unknown. Interestingly, the results thus obtained are quite consistent with the deductions from the reports by other investigators. It is anticipated that, with the continuous increase of the chem.-chem. interaction data, the current method will be further enhanced in its power and accuracy, so as to become a useful complementary vehicle in annotating uncharacterized compounds for their biol. functions. A dissertation. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).HPLC of Formula: 132-20-7

The Article related to carbohydrate energy lipid biol function, metabolic pathway chem interaction, Pharmacology: Methods and other aspects.HPLC of Formula: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On February 28, 2010, Cox, Geoffrey B.; Maier, Norbert M.; Zhang, Tong; Franco, Pilar published an article.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Enantioselective reversed-phase chromatography with protein-based columns. And the article contained the following:

Excellent reversed-phase separations using a protein-based column, CHIRAL-AGP, with volatile LC-MS compatible buffer systems have been obtained for a range of basic solutes. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to reversed phase chromatog chiral agp ammonium acetate, Pharmacology: Methods and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 31, 2018, Wang, Bingbing; Parobchak, Nataliya; Martin, Adriana; Rosen, Max; Yu, Lumeng Jenny; Nguyen, Mary; Gololobova, Kseniya; Rosen, Todd published an article.Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Screening a small molecule library to identify inhibitors of NF-kappaB inducing kinase and pro-labor genes in human placenta. And the article contained the following:

The non-canonical NF-kappaB signaling (RelB/p52) pathway drives pro-labor genes in the human placenta, including corticotropin-releasing hormone (CRH) and cyclooxygenase-2 (COX-2), making this a potential therapeutic target to delay onset of labor. Here we sought to identify small mol. compounds from a pre-existing chem. library of orally active drugs that can inhibit this NF-kappaB signaling, and in turn, human placental CRH and COX-2 production We used a cell-based assay coupled with a dual-luciferase reporter system to perform an in vitro screening of a small mol. library of 1,120 compounds for inhibition of the non-canonical NF-kappaB pathway. Cell toxicity studies and drug efflux transport MRP1 assays were used to further characterize the lead compounds We have found that 14 drugs have selective inhibitory activity against lymphotoxin beta complex-induced activation of RelB/p52 in HEK293T cells, several of which also inhibited expression of CRH and COX-2 in human term trophoblast. We identified sulfapyridine and propranolol with activity against CRH and COX-2 that deserve further study. These drugs could serve as the basis for development of orally active drugs to affect length of gestation, first in an animal model, and then in clin. trials to prevent preterm birth during human pregnancy. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to placenta nf kappa b small mol, Pharmacology: Methods and other aspects.Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 15, 2013, Wirasorn, Kosin; Ngamprasertchai, Thundon; Chindaprasirt, Jarin; Sookprasert, Aumkhae; Khantikaew, Narong; Pakkhem, Ake; Ungarereevittaya, Piti published an article.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Prognostic factors in resectable cholangiocarcinoma patients: Carcinoembryonic antigen, lymph node, surgical margin and chemotherapy.. And the article contained the following:

AIM: To evaluate outcomes in resectable cholangiocarcinoma patients and to determine prognostic factors. METHODS: A retrospective study was conducted among newly-diagnosed cholangiocarcinoma patients from January 2009 to December 2011 who underwent curative resection in Srinakarind Hospital (a 1000-bed university hospital). Two hundred and sixty-three cholangiocarcinoma patients with good performance were enrolled. These patients had pathological reports with clear margins or microscopic margins. Prognostic factors which included clinical factors, serum liver function test as well as serum tumor makers at presentation, tumor data, and receiving adjuvant chemotherapy were determined by uni- and multivariate analysis. RESULTS: The median overall survival time was 17 mo (95%CI: 13.2-20.7); and 1-, 2-, and 3- year survival rates were 65.5%, 45.2% and 35.4%. Serum albumin levels, serum carcinoembryonic antigen (CEA) levels, staging classifications by American Joint Committee on cancer, pathological tumor staging, lymph node metastases, tumor grading, surgical margin status, and if adjuvant chemotherapy was administered, were shown to be significant prognostic factors of resectable cholangiocarcinoma by univariate analysis. Multivariate analysis, however, established that only abnormal serum CEA [hazard ratio (HR) 1.68; P = 0.027] and lymph node metastases (HR 2.27; P = 0.007) were significantly associated with a decrease in overall survival, while adjuvant chemotherapy (HR 0.71; P = 0.067) and surgical margin negative (HR 0.72; P = 0.094) tended to improve survival time. CONCLUSION: Serum CEA and lymph node metastases which were associated with advanced stage tumors become strong negative prognostic factors in cholangiocarcinoma. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to adjuvant, carcinoembryonic antigen, chemotherapy, cholangiocarcinoma, hepatectomy, lymph nodes, neoplasm metastasis, prognosis, surgical margin status, survival rate, and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 30, 2011, Borkar, Nitin; Sawant, Sakshi published an article.Application of 132-20-7 The title of the article was Review of simultaneous determination of analytes by high performance liquid chromatography (HLPC) in multicomponent cough and cold oral drug products. And the article contained the following:

A review. The objective of this article is to review the methodologies of determination of the most widely used analytes in cough and cold preparations by HPLC. This article studies the effect of all chromatog. parameters so as to provide a fast, reliable and cost effective methodol. of testing. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application of 132-20-7

The Article related to review cough cold oral drug analysis hplc, Pharmaceutical Analysis: Reviews and other aspects.Application of 132-20-7

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pandey, Ajay Kumar; Dwivedi, Dharmendra published an article in 2017, the title of the article was A validated titrimetric method for the determination of pheniramine maleate in pure form and in their pharmaceutical formulation.SDS of cas: 132-20-7 And the article contains the following content:

A simple, convenient and accurate visual titrimetric method for the determination of Pheniramine maleate (PM) in pure form and in their pharmaceutical formulations Avil (tablet and injection) using Pyridinium fluoro chromate (PFC) as an oxidant is described. The titrimetric method is based on the oxidation of the drugs in sulfuric acid medium by known excess of Pyridinium fluoro chromate and iodometric determination of the unreacted Pyridinium fluoro chromate (PFC). To examine the accuracy and precision of results percentage error, standard deviation (SD) and coefficient of variation (CV) were also calculated for each sample. Proposed method was validated by recovery anal. by drug addition method of drug. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).SDS of cas: 132-20-7

The Article related to pheniramine maleate avil tablet titrimetry, Pharmaceutical Analysis: General and other aspects.SDS of cas: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kelani, Khadiga M.; Hegazy, Maha A.; Hassan, Amal M.; Tantawy, Mahmoud A. published an article in 2021, the title of the article was Determination of naphazoline HCl, pheniramine maleate and their official impurities in eye drops and biological fluid rabbit aqueous humor by a validated LC-DAD method.COA of Formula: C20H24N2O4 And the article contains the following content:

A simple RP-HPLC-DAD method was developed and validated, as per the ICH guidelines, for simultaneous determination of naphazoline HCl (NPZ) & pheniramine maleate (PHN) along with three of their official impurities. Chromatog. separation was performed on a hypersil ODS column (5 mm, 250-4.6 mm i.d.) with isocratic elution using phosphate buffer pH 6.0: acetonitrile (70 : 30, volume/volume) as mobile phase, at a flow rate of 1.0 mL min-1 and UV detection at 260.0 nm. The developed method was found to be linear over the concentration ranges of 5.00-45.00 Μg mL-1 for NPZ and NPZ impurity B and 10.00-110.00 Μg mL-1, 10-70 Μg mL-1 and 10-120 Μg mL-1 for PHN, and PHN impurity A and B, resp., with correlation coefficient values <0.999 for the five cited compounds The method was confirmed to be accurate, robust and precise with RSD >2.0%. LOD and LOQ values for the five cited compounds were calculated Moreover, the method was also validated in rabbit aqueous humor as per the US food and drug administration (FDA) bioanal. validation guidelines. Finally, the proposed method was applied for the anal. of the two drugs along with their impurities in dosage form and spiked aqueous humor samples. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).COA of Formula: C20H24N2O4

The Article related to naphazoline hcl pheniramine maleate eye drop biol fluid, Biochemical Methods: Immunological and other aspects.COA of Formula: C20H24N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem