Category: 132-20-7

Eltsova, Natalia O.; Budko, Elena V.; Yampolskii, Leonid M.; Kulikov, Alexander L. published an article in 2016, the title of the article was UPLC study of inter-component interaction in the system “naproxen – pheniramine maleate”.Computed Properties of 132-20-7 And the article contains the following content:

The anal. was performed for the two-component system “naproxen – pheniramine maleate” using the method UPLC. It is concluded that strengthening the destructive processes in the presence of pheniramine maleate with naproxen based on the chromatogram initial substances at influence of stress factors and identified degradation products. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Computed Properties of 132-20-7

The Article related to naproxen pheniramine maleate inter component interaction uplc, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 2011, Murahdharan, Balathandapani; Gopu, Gopalakrishnan; Laya, Saraswathy; Vedhi, Chinnapiyan; Manisankar, Paramasivam published an article.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was A study on preparation and use of nano poly pyrrole and nano poly (3,4-ethylenedioxythiophene) coated glassy carbon electrode for the determination of antihistamine in pharmaceutical and urine sample. And the article contained the following:

Pheniramine maleate (PA), an antihistamine, was determined by Differential Pulse Stripping voltammetry using nano polypyrrole (Ppy) and nano poly (3,4-ethylenedioxythiophene) (PEDOT) modified glassy carbon electrodes. The cyclic voltammetric behavior of pheniramine was studied in aqueous acidic, neutral and alk. conditions. One well-defined oxidation peak was observed in the cyclic voltammograms at all pHs. The influence of pH, scan rate and concentration revealed irreversible electron transfer and the oxidation was diffusion controlled adsorption. The SEM anal. confirmed good accumulation of PA on the electrode surface. A systematic study of influence of various exptl. parameters that affect the stripping voltammetric response was carried out and the maximum peak current conditions were arrived at. Calibration was made under maximum peak current conditions. The range of study was 0.05 to 0.4 μg/mL on Ppy/GCE and 0.025 to 0.4 μg/mL on PEDOT/GCE and the lower limit of determination were 0.035 μg/mL on Ppy/GCE and 0.016 μg/mL on PEDOT/GCE. The suitability of the method for the determination of PA in pharmaceutical preparations and urine samples was also ascertained. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to polypyrrole ethylenedioxythiophene glassy carbon electrode nanoparticle antihistamine pheniramine maleate, Pharmacology: Drug Interactions and General Pharmacology and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 2011, Mehul, Dave; Senthil, A.; Hardik, Thakkar R.; Ravikumar; Tejas, Lad published an article.SDS of cas: 132-20-7 The title of the article was Formulation and evaluation of orodispersible tablets of pheniramine maleate. And the article contained the following:

Orodispersible tablets of pheniramine maleate were prepared by direct compression method using three super disintegrants, viz., croscarmellose sodium, crospovidone and sodium starch glycolate at different concentrations with microcrystalline cellulose were used along with sodium bicarbonate and citric acid as effervescent agent. Orodispersible tablet is the fast growing and highly accepted drug delivery system, convenience of self administration, compactness and easy manufacturing Pheniramine maleate is a member of alkylamine class of H1 receptor antagonists. It is an antihistamine used in the treatment of allergic conditions including urticaria and angioedema. It is completely absorb after oral administration. The bland were examined for angle of repose, bulk d., tapped d., compressibility index and hausner’s ratio. The prepared tablets were evaluated for thickness, hardness, friability, and weight variation, content uniformity, wetting time, Water absorption ratio, in-vitro dispersion time, dissolution studies and FTIR studies. Twelve formulations F1 to F12 were prepared with three super disintegrants with different concentration The optimum formulation was chosen and their optimum results were found to be in close agreement with exptl. finding. Among three super disintegrants crospovidone F5 emerged as overall best formulation. Short-term stability studies on the formulations indicated no significant changes in the drug content and in vitro dispersion time (p < 0.05). The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).SDS of cas: 132-20-7

The Article related to pheniramine maleate orodispersible tablet formulation superdisintegrant, Pharmaceuticals: Formulation and Compounding and other aspects.SDS of cas: 132-20-7

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 30, 2014, Kouki, Noura; Tayeb, Rafik; Dhahbi, Mahmoud published an article.Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Recovery of acetaminophen from aqueous solutions using a supported liquid membrane based on a quaternary ammonium salt as ionophore. And the article contained the following:

A flat sheet-supported liquid membrane (FSSLM) system, consisting of an ionic liquid, tricapryl-methylammonium chloride (Aliquat 336) in octan-2-ol, is proposed as a means of recovering acetaminophen (Ac) from aqueous solutions; Ac is an active ingredient widely used in many pharmaceutical preparations Several parameters which could affect the transport efficiency were examined, i.e., the strippant nature and concentration in the receiving solution, the diluent nature, carrier concentration, initial acetaminophen concentration in the feed solution, and the polymeric support type. A facilitated transport was obtained by impregnating the polymeric support with 10 volume ^of Aliquat 336 in octan-2-ol, 1 M NaOH as a receiving solution, and a feed solution of Ac dissolved in ultrapure water. The study was completed by using the FSSLM thus developed for extracting Ac from some drugs in frequent use in Tunisia (Analgan, Doliprane, and Fervex). The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to acetaminophen aqueous liquid membrane quaternary ammonium salt ionophore, Pharmaceuticals: Formulation and Compounding and other aspects.Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 31, 2020, Rodriguez-Medina, Carlos; Martinez-Cuadron, David; Cano, Isabel; Gil, Cristina; Tormo, Mar; Martinez-Sanchez, Maria del Pilar; Bernal del Castillo, Teresa; Serrano-Lopez, Josefina; Benavente, Celina; Herrera-Puente, Pilar; Garcia-Boyero, Raimundo; Lavilla-Rubira, Esperanza; Amigo, Ma. Luz; Sayas-Lloris, Ma. ose; Bergua-Burgues, Juan M.; Perez-Simon, Jose Antonio; Rodriguez, Gabriela; Espadana, Ana; Vidriales-Vicente, Belen; Fernandez, Rosa; Lopez-Lorenzo, Jose Luis; Lopez, Maria; Garcia-Fortes, Maria; Labrador Gomez, Jorge; Colorado-Araujo, Mercedes; Sossa-Melo, Claudia Lucia; Aguilar, Eliana; Montesinos Fernandez, Pau published an article.HPLC of Formula: 132-20-7 The title of the article was Performance of prognostic scoring systems in elderly patients with acute myeloid leukaemia on intensive chemotherapy: A PETHEMA registry study. And the article contained the following:

Selection of elderly patients (aged ≥60 years) for intensive chemotherapy treatment of acute myeloblastic leukemia (AML) remains challenging. Several cooperative groups such as Acute Leukemia French Association (ALFA), Haematol. Oncol. Clin. Studies Group (HOCSG) and MD Anderson Cancer Center (MDACC) have developed predictive models to select those patients who can benefit from intensive chemotherapy. Our purpose is to validate and compare these three models in a cohort of patients treated in real-life setting. For this, a total of 1724 elderly AML patients and treated with intensive chemotherapy regimens were identified in the PETHEMA registry. Median age was 67.2 years (range, 60-84,9) and median overall survival [OS] 9 mo (95% confidence interval [CI], 8.2-9.7). Taking into account the ALFA group’s model, patients likely to benefit from intensive chemotherapy had longer OS (14 mo, 95% CI 12.3-15.7) than those unlikely to benefit (5 mo, 95% CI 4.1-5.9; p < 0.001). Significant differences in OS were observed between patients with favorable risk (17 mo, 95% CI 13.2-20.7), intermediate risk (11 mo, 95% CI 9.3-12.6) and adverse risk (6 mo, 95% CI 5.1-6.4; p < 0.001) according to the HOCSG model. No significant differences in OS were observed between patients with 0, 1, 2 or ≥3 points according to the MDACC model. However, when patients with ≥1 point were compared with those with 0 points, median OS was significantly longer in the latter [15 mo (95% CI 12.1-17.8) vs 7 (95% CI 5.7-8.5)]. This retrospective study validates predictive models proposed by the ALFA, HOCSG and MDACC groups in this real-life cohort. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).HPLC of Formula: 132-20-7

The Article related to human acute myeloid leukemia prognosis intensive chemotherapy, acute myeloid leukemia, elderly, intensive chemotherapy, overall survival, prognosis, Mammalian Pathological Biochemistry: Oncology and other aspects.HPLC of Formula: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 25, 2012, Lai, Yonghua; Huang, Taomin; Wang, Donglei; Chen, Nianzu published an article.HPLC of Formula: 132-20-7 The title of the article was Determination of pheniramine maleate content in pheniramine maleate-naphazoline hydrochloride eye drops by reverse-phase high performance liquid chromatography. And the article contained the following:

The purpose of the research is to develop a reverse-phase high performance liquid chromatog.(RP-HPLC) method to determine pheniramine maleate concentration in the pheniramine maleate-naphazoline hydrochloride eye drops. The HPLC separation was carried out on an Agilent C18(150 mm*4.6 mm, 5μm) column, using a UV detector with 262 nm wavelength. The mobile phase was 0.1 mol·L-1 ammonium acetate buffer(0.5% triethylamine, adjusted to pH 4.0 with acetic acid)-methanol solution=97:3(V/V), with velocity of 1 mL·min-1 and column temperature of 20°C. The good linearity of pheniramine maleate under chromatog. was found(r>0.999, n=7). The recovery values were between 97% and 103%(n=3). The RSD values were below 2.0%(n=3). The sample was stable in 24 h. The samples reached standardized qualification. RP-HPLC is proved to be a simple, swift, accurate and reliable method and has good reproducibility. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).HPLC of Formula: 132-20-7

The Article related to pheniramine maleate content rp hplc, Pharmaceutical Analysis: Natural Drug Materials and other aspects.HPLC of Formula: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 31, 2022, Kelani, Khadiga M.; Hegazy, Maha A.; Hassan, Amal M.; Tantawy, Mahmoud A. published an article.Recommanded Product: 132-20-7 The title of the article was A green TLC densitometric method for the simultaneous detection and quantification of naphazoline HCl, pheniramine maleate along with three official impurities. And the article contained the following:

Impurity profiling of a pharmaceutical compound is now taking great attention during quality assessment of pharmaceuticals, as presence of small amount of impurities may affect safety and efficacy. In this work, a novel TLC chromatog. method coupled with densitometric detection was established for the simultaneous quantification of naphazoline HCl, pheniramine maleate and three of their official impurities, namely; naphazoline impurity B, pheniramine impurities; A & B. Chromatog. separation was carried out on TLC aluminum silica plates F254, as a stationary phase, using methanol: Et acetate: 33.0% ammonia (2.0: 8.0: 1.0, by volume), as a mobile phase. Plates were examined at 260.0 nm and International Council for Harmonisation (ICH) guidelines were followed for method’s validation. Important factors, such as; composition of mobile phase and detection wavelengths were optimized. Linearity was achieved over the ranges of 2.0-50.0μg band-1 for naphazoline, 10.0-110.0μg band-1 for pheniramine, 0.1-10.0μg band-1 for naphazoline impurity B and 2.0-50.0μg band-1 for both pheniramine impurities. The proposed method was assessed in terms of accuracy, precision and robustness where satisfactory results (recovery % ≈ 100% and RSD < 2) were obtained. The method was also applied for the simultaneous determination of naphazoline HCl and pheniramine maleate, in Naphcon-A eye drops, with resp. recoveries of 101.36% and 100.94%. Method greenness was evaluated and compared to the reported HPLC one via environmental, health and safety tool. The developed method has much potential over the reported one of being simple, selective, economic and time saving for the anal. of the five cited compounds The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Recommanded Product: 132-20-7

The Article related to green tlc densitometric method naphazoline hcl pheniramine maleate, ehs tool, impurities, naphazoline, pheniramine, tlc, Pharmaceutical Analysis: Natural Drug Materials and other aspects.Recommanded Product: 132-20-7

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bhagat, Rakshanda; Sheikh, Amir Amin; Dar, Rouf Rashid; Dogra, Pooja; Islam, Sheikh Tajamul published an article in 2017, the title of the article was A clinical case of ear canker and alopecia in a rabbit.Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

A two year old male rabbit was presented with history of itching; rough hair coat and hair fall from last 15 days with reddish brown crust formation on ears, paws and around eyes. Skin scraping revealed the presence of Psoroptes cuniculi (ear mite) thus diagnosing the case of ear canker. Treatment with Ivermectin (Ivomec) @ 0.02mg/kg S.c. weekly for 4 wk, Pheniramine maleate (Avil) @ 0.5 mg/kg I.m. and topical application of honey and turmeric mix daily for 1 wk was accomplished which resulted in substantial clin. improvement recorded in terms of decreased frequency of itching, regained smooth hair coat and lusture of hair and skin. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to ear canker alopecia rabbit, Mammalian Pathological Biochemistry: Skin Diseases and other aspects.Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaji, Ayumi; Hashimoto, Yoshitaka; Sakai, Ryosuke; Okada, Hiroshi; Hamaguchi, Masahide; Ushigome, Emi; Majima, Saori; Yamazaki, Masahiro; Fukui, Michiaki published an article in 2019, the title of the article was Frequent usage of convenience stores is associated with low diet quality.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

In Japan, convenience stores are more common, and it is thus more important to assess whether people use convenience stores than the d. or availability of the convenience stores. In this cross-sectional study of patients with type 2 diabetes, the association between the usage of the convenience stores and dietary habits or the prevalence of hypertension was evaluated. Among the 206 men and 161 women in the study, 24 men and 9 women used convenience stores three or more times per wk. Fruit and vegetable intake (men, 132 (102-191) vs. 192 (128-267) g/1000 kcal, p = 0.019; and women, 178 (132-207) vs. 239 (172-313) g/1000 kcal, p = 0.063) of patients who frequently use convenience stores was lower compared to those who did not. Net endogenous acid production score (men, 55.2 (45.4-65.2) vs. 48.9 (42.3-56.8) mEq/day, p = 0.013; and women, 56.9 (52.6-59.8) vs. 46.3 (40.9-54.0) mEq/day, p = 0.050) and intake of carbohydrate to fiber ratio (men, 21.5 (20.0-29.3) vs. 19.9 (15.7-25.0), p = 0.052; and women, 21.0 (18.9-23.9) vs. 16.2 (13.8-20.3), p = 0.017) of patients who frequently use convenience stores were higher compared to those who did not. Addnl., frequent usage of convenience stores was associated with the prevalence of hypertension after adjusting for covariates (5.01; 95% confidence interval, 1.12-22.50; p = 0.035). In conclusion, frequent usage of convenience stores is associated with low diet quality and the prevalence of hypertension. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to diabetes convenience store low diet quality, convenience store, diet quality, food environment, habitual diet intake, lifestyle, type 2 diabetes, Animal Nutrition: Carbohydrates, Fiber, and Energy and other aspects.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 15, 2013, Youngvises, Napaporn; Chaida, Thanatcha; Khonyoung, Supada; Kuppithayanant, Nattawan; Tiyapongpattana, Warawut; Itharat, Arunporn; Jakmunee, Jaroon published an article.Category: pyridine-derivatives The title of the article was Greener liquid chromatography using a guard column with micellar mobile phase for separation of some pharmaceuticals and determination of parabens. And the article contained the following:

In this research, a greener chromatog. employing a short column, Zorbax SB C18 cartridge (12.5 × 4.6 mm, 5 μm) commonly used as a guard column in a reverse phase high performance liquid chromatog. (RP-HPLC), was utilized as the anal. column in conjunction with a more eco-friendly micellar mobile phase of sodium dodecyl sulfate (SDS) for separation tertiary mixtures of local anesthetics and antihistamines; and binary mixture of colds drugs; and quaternary mixture of some parabens with different separation conditions. The chromatog. behavior of these analytes was studied to demonstrate separation efficiency of this guard column in a micellar mobile phase. Moreover, this column and SDS mobile phase was exploited for determination of parabens in 64 samples of cosmetic product, both those that were produced locally in the community and those that were com. manufactured Linear calibration graphs of the parabens as detected at 254 nm were obtained in the range of 1-100 μmol L-1 with R2>0.9990. Percentage recoveries were 92.4-109.2 with %RSD<3, and the limit of detection and quantitation were 0.04-0.10 and 0.20-0.80 μmol L-1, resp. This anal. system is not only greener but also faster and employing simpler sample preparation than a conventional liquid chromatog. system. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Category: pyridine-derivatives

The Article related to green liquid chromatog micelle mobile pharmaceutical paraben, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem