Category: 132-20-7

On November 30, 2013, Raghu, M. S.; Basavaiah, K.; Abdulrahaman, Sameer A. M.; Prashanth, K. N.; Vinay, K. B. published an article.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Sensitive and selective spectrophotometric methods for the determination of pheniramine maleate in bulk drug and in its formulations using sodium hypochlorite. And the article contained the following:

Two simple, selective and sensitive spectrophotometric methods for the determination of pheniramine maleate (PAM; H1 histamine receptor antagonist) in pharmaceutical pure and dosage forms are described. The methods are based on the reaction of PAM with Na hypochlorite in Kolthoff phosphate-borate buffer pH 7.0 leading to the PAM chloro derivative, subsequent decomposition of excess hypochlorite by Na nitrite (the PAM chloro derivative is not affected under optimized conditions), followed by the oxidation of K iodide with the PAM chloro derivative to iodine (I3-) colored product, which is measured either directly at 355 (method A; yellow product) or after reaction with starch at 590 nm (method B; blue product). The optimal conditions for the PAM-hypochlorite reaction were detd; under these conditions the linear relationship was found in the concentration ranges of 2-50 and 1-25 μg PAM/mL with methods A and B, resp. The calculated molar absorptivity values were 7.26 × 103 and 1.28 × 104 L/(mol cm) for methods A and B, resp. Sandell sensitivity values, limits of detection (LOD), and limits of quantification (LOQ) were calculated The proposed methods were used for the determination of PAM in tablets and injection solutions with good accuracy and precision and without interferences from common pharmaceutical additives. The obtained results compared favorably with those of the reference method. The accuracy and reliability of the proposed methods were further checked by recovery studies via standard addition procedure. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to pharmaceutical analysis pheniramine maleate spectrophotometry sodium hypochlorite reagent, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

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Pyridine – Wikipedia,
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Caglar, Hatice; Bueyuektuncel, Ebru published an article in 2014, the title of the article was HPLC method development and validation: simultaneous determination of active ingredients in cough and cold pharmaceuticals.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

Objective: This study aimed to develop a simple reversed-phase high performance chromatog. method for simultaneous determination of pseudoephdrine HCI, pheniramine maleate, acetaminophen, guaifenisin, pyrilamine maleate, chlorpheniramine maleate, triprolidine HCI, dextromethorphan HBr, diphenhydramine HCI in cough and cold pharmaceuticals. Methods: The separation of these compounds was achieved within 37.9 min on a Nucleodur gravity C18 column (250 x 4.0 mm, 5μm). The chromatog. separation of these compounds performed in a single run by using isocratic mobile phase consisting of methanol:buffer mixture (38:62, volume/volume) at room temperature, with flow rate of 0.75 mL.min-1. An UV absorption at 210 nm was monitored. 2,4,6-trimethoxybenzaldehyde was used as an internal standard (ISTD). The selectivity, linearity of calibration, accuracy, intraday and interday precision and forced degradation studies were examined as parts of the method validation. Results: The concentration-response relationship was linear over a concentration range of 0.2-250 μg.mL-1 for acetaminophen, 0.5-250 μg.mL-1 for pseudoephdrine HCI and pheniramine maleate, 1-250 μg.mL-1 for guaifenisin, 2.5-250 μg.mL-1 for chlorpheniramine maleate and triprolidine HCI, 5-250 μg.mL-1 for pyrilamine maleate and diphenhydramine HCI, 10-20 μg.mL-1 for dextromethorphan HBr with correlation coefficients better than 0.9993. The relative standard deviations of the intraday and interday were all less than 4%. Conclusion: The proposed liquid chromatog. method was successfully applied for the routine anal. of these compounds in different cough and cold pharmaceutical preparations such as syrups and tablets. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to reversed phase high performance chromatog, cough cold pharmaceutical active ingredient, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

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Huang, Taomin; Chen, Nianzu; Wang, Donglei; Lai, Yonghua; Cao, Zhijuan published an article in 2014, the title of the article was A validated stability-indicating HPLC method for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations.Computed Properties of 132-20-7 And the article contains the following content:

Background: A simple, rapid, and accurate stability-indicating reverse phase liquid chromatog. method was developed and validated for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in bulk drugs and pharmaceutical formulations. Results: Optimum chromatog. separations among pheniramine maleate, naphazoline hydrochloride and stress-induced degradation products have been achieved within 10 min by using an Agilent zorbax eclipse XDB C18 column (150 mm × 4.6 mm, 5 μm) as the stationary phase with a mobile phase consisted of 10 mM phosphate buffer pH 2.8 containing 0.5% triethlamine and methanol (68:32, volume/volume) at a flow rate of 1 mL min-1. Detection was performed at 280 nm using a diode array detector. Theor. plates for pheniramine maleate and naphazoline hydrochloride were calculated to be 6762 and 6475, resp. The method was validated in accordance with ICH guidelines with respect to linearity, accuracy, precision, robustness, specificity, limit of detection and quantitation. Regression anal. showed good correlations (R2 > 0.999) for pheniramine maleate in the concentration range of 150-1200 μg mL-1 and naphazoline hydrochloride in 12.5-100 μg mL-1. The method results in excellent separation of both the analytes and degradation products. The peak purity factor is ≥980 for both analytes after all types of stress, indicating complete separation of both analyte peaks from the stress induced degradation products. Conclusions: Overall, the proposed stability-indicating method was suitable for routine quality control and drug anal. of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Computed Properties of 132-20-7

The Article related to naphazoline hydrochloride pharmaceutical formulation quality control rphplc, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Computed Properties of 132-20-7

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Pandey, Ajay Kumar; Dwivedi, Dharmendra published an article in 2019, the title of the article was Oxidative determination of some antihistamine drugs in pure form and their pharmaceutical preparations by using Pyridinium fluoro chromate (PFC) reagent.Computed Properties of 132-20-7 And the article contains the following content:

In this paper Chromium (VI) based Pyridinium fluoro chromate (PFC) reagent has been used as an oxidant for the determination of some antihistamine drugs e.g. Promethazine hydrochloride (PMH) and Pheniramine maleate (PM) in pure form and their pharmaceutical preparations such as Phenergan (Injection and tablet) and Avil (Tablet and injection) resp. The main principle of this method is based on the fact, that each pharmaceutical drug contains a specific organic functional group, which on oxidation in the presence of selected oxidant (Here PFC is used as an oxidant) provides the new oxidized product. This type of oxidation reaction between the drug mol. and an oxidant establishes a stoichiometric relationship between the drug mol. and an oxidant. This relationship is the basis of quant. estimation of drugs in pure form and their pharmaceutical preparations In this research, oxidizing reagent Pyridinium fluoro chromate (PFC) oxidizes the sulfur atom of Promethazine hydrochloride (PMH) to the corresponding sulfoxide, whereas in case of Pheniramine maleate (PM) it oxides one hydroxyl (-OH) group of carboxylic (-COOH) group to corresponding aldehydic (-CHO) group. Thus an oxidant PFC establishes a 1:1 ratio with both Promethazine hydrochloride (PMH) and Pheniramine maleate (PM) drug. Oxidative determination of these drugs was carried out by adopting the iodometric titration (Visual volumetric) method. The applied technique was very simple, convenient, accurate, precise and economical. To examine the accuracy and precision of results various statistical anal. such as percentage error, standard deviation (SD) and coefficient of variation (CV) was also calculated for each sample. The proposed method was validated by recovery anal., by drug addition method. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Computed Properties of 132-20-7

The Article related to antihistamine oxidation pyridinium fluoro chromate iodometric titration, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Computed Properties of 132-20-7

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Pandey, Ajay Kumar; Dwivedi, Dharmendra published an article in 2018, the title of the article was Titrimetric assay of some antihistamines with pyridinium fluoro chromate (PFC) reagent.Computed Properties of 132-20-7 And the article contains the following content:

In the present paper, simple, convenient accurate, precise and cost effective titrimetric (Visual volumetric) method has been reported for the estimation of some antihistamine drugs e.g. Cyproheptadine hydrochloride (CPH), Fexofenadine hydrochloride (FFH), Promethazine hydrochloride (PMH) and Pheniramine maleate (PM) in pure form and in their pharmaceutical preparations such as Ciplactin (Tab), Allegra (Tab), Phenergan (Tab and Inj) and Avil (Tab and Inj) with Pyridinium fluoro chromate (PFC) reagent. The principle of this method is based on the fact, that each pharmaceutical drug consists of certain organic functional group which on oxidation by a known excess of potassium iodate in sulfuric acid medium followed by iodometric titration in presence of reagent Pyridinium fluoro chromate (PFC) establishes stoichiometric relationship between drug mol. and an oxidising reagent Pyridinium fluoro chromate (PFC). Different results obtained for each drug during experiment, has been validated by different statistical parameters such as percentage error, standard deviation (SD) and coefficient of variation (CV). Results obtained from these statistical parameters proves the accuracy and precision of adopted method. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Computed Properties of 132-20-7

The Article related to titrimetry ciplactin allegra phenergan avil pyridinium fluoro chromate, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Computed Properties of 132-20-7

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Pyridine – Wikipedia,
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Mehmood, Yasir; Saleem, Noviara; Mahmood, Rana Khalid; Riaz, Humayun; Atif, Raza Syed published an article in 2016, the title of the article was Analytical method development and validation of pheniramine maleate injection.SDS of cas: 132-20-7 And the article contains the following content:

Pheniramine Maleate assay in its injection formulation was performed using spectrophotometric estimation in UV/Vis-region and non-aqueous titration method. The method have been developed and validated in spectrophotometric Method and water was used as diluent which does not shows any interference in spectrophotometric estimations ICH guidelines were used to determine the anal. parameter. RSD and %RSD were obtained statistically along with neat chromatograms. Precision and accuracy of the results were obtained also which showed that the method is very accurate for quant. estimation of Pheniramine Maleate in injection dosage forms. Another simple titrimetric method is described for the determination of Pheniramine Maleate (PM) in pure form and in injection dosage forms. The principle involved in the method is simple acid-base reaction in which the perchloric acid is used as titrant and naphthol benzene as indicator. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).SDS of cas: 132-20-7

The Article related to pheniramine maleate injection dosage form uv visible spectrophotometry, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.SDS of cas: 132-20-7

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Pyridine – Wikipedia,
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Franco, Marina; Jasionowska, Renata published an article in 2013, the title of the article was Quick single run Capillary Zone Electrophoresis determination of active ingredients and preservatives in pharmaceutical products.Product Details of 132-20-7 And the article contains the following content:

The paper deals with the development of a rapid and efficient Capillary Zone Electrophoresis (CZE) method for Quality Control anal. of pharmaceutical preparations containing antihistamines, decongestants, anticholinergic remedies and preservatives. Active ingredients of interest are: ChlorPheniramine Maleate (CPM), DiPhenhydramine Hydrochloride (DPH), Ephedrine hydrochloride (E), Isopropamide Iodide (II), Pheniramine Maleate (PM), Lidocaine hydrochloride (L), Tetracaine hydrochloride (T), Clopamide Hydrochloride (CH) , DiHydroErgochristine (DHE), PhenylEphrine hydrochloride (PE) and Acetaminophen (A). Preservatives studied are: MethylParaben (MeP), EthylParaben (EtP), PropylParaben (PrP), ButylParaben (BuP), p-HydroxyBenzoic Acid (p-HBA). All these analytes were separated in a single run using 60 mM tetraborate buffer solution (TBS) pH = 9.2 as a BackGround Electrolyte (BGE) by an uncoated fused silica capillary of I.D. = 50 μm and applying a voltage of 25 kV in the first part of the electrophoretic run (up to 5.8 min) and 30 kV for the remaining time. The hydrodynamic pressurization of the inlet vial was 20 psi at 7.2 min. up to the end of anal. Total separation time was of 7.5 min. The method was then successfully validated and applied to the simultaneous determination of active ingredients and preservatives. Good repeatability, linearity, and sensitivity were demonstrated. Precision of migration time ™ was RSD% <0.53% and of corrected peak area (Ac) was RSD% <6.15%. The linearity evaluation gave 0.9928 < r2 < 1.000. LOD and LOQ, accuracy (recovery) and ruggedness were evaluated for each analyte demonstrating the good reliability of the method. Analyses of some pharmaceutical real samples were performed. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Product Details of 132-20-7

The Article related to pharmaceutical preservative analysis capillary zone electrophoresis, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Product Details of 132-20-7

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Pyridine – Wikipedia,
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On March 31, 2012, Raghu, M. S.; Basavaiah, K.; Ramesh, P. J.; Abdulrahman, Sameer A. M.; Vinay, K. B. published an article.SDS of cas: 132-20-7 The title of the article was Development and validation of a UV-spectrophotometric method for the determination of pheniramine maleate and its stability studies. And the article contained the following:

A sensitive, precise, and cost-effective UV-spectrophotometric method is described for the determination of pheniramine maleate (PAM) in bulk drug and tablets. The method is based on the measurement of absorbance of a PAM solution in 0.1 N HCl at 264 nm. As per the International Conference on Harmonization (ICH) guidelines, the method was validated for linearity, accuracy, precision, limits of detection (LOD) and quantification (LOQ), and robustness and ruggedness. A linear relationship between absorbance and concentration of PAM in the range of 2-40 μg/mL with a correlation coefficient (r) of 0.9998 was obtained. The LOD and LOQ values were found to be 0.18 and 0.39 μg/mL PAM, resp. The precision of the method was satisfactory: the value of relative standard deviation (RSD) did not exceed 3.47%. The proposed method was applied successfully to the determination of PAM in tablets with good accuracy and precision. Percentages of the label claims ranged from 101.8% to 102.01% with the standard deviation (SD) from 0.64% to 0.72%. The accuracy of the method was further ascertained by recovery studies via a standard addition procedure. In addition, the forced degradation of PAM was conducted in accordance with the ICH guidelines. Acidic and basic hydrolysis, thermal stress, peroxide, and photolytic degradation were used to assess the stability-indicating power of the method. A substantial degradation was observed during oxidative and alk. degradations No degradation was observed under other stress conditions. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).SDS of cas: 132-20-7

The Article related to pheniramine maleate determination uv spectrophotometry stability, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.SDS of cas: 132-20-7

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Pyridine – Wikipedia,
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Sawant, Sakshi; Borkar, Nitin published an article in 2015, the title of the article was Validation of high performance liquid chromatographic method for the simultaneous determination of common cough and cold ingredients in multicomponent oral drug products.HPLC of Formula: 132-20-7 And the article contains the following content:

This research was done to develop a potential, reliable fast and efficient anal. method for various dosage forms eg. Syrup, tablet, suspension etc which could estimate all the major components of a cough and cold multicomponent formulation and also this method was validated. All common used components like pheniramine maleate, phenylephrine hydrochloride, acetaminohen, dextromethorphan hydrobromide, guafenesin, chlorpheniramine maleate, diphenhydramine in cough and cold category of products also covering more than one dosage forms eg. Syrups, suspensions, tablet etc was used thus making the methodol. by and large universal for the entire range of cough and cold products. This would help in using almost a common method of anal. for separation of most of the components instead of using a lot of sep. methods for the same product or using a common method of anal. for a range of different dosage form of cough and cold category for a common set of components. This would save time and cost and ensure optimum usage of resources. Mobile phase of 0.01M 1-octane sulfonic acid sodium salt monohydrate pH adjusted to 2.80 with 0rthophosphoric acid: Acetonitrile in a gradient ratio was used with a flow rate of 1.0 mL/min on a C18, 25 × 4.6 mm id, 5μ column at a wavelength of 264nm. This method was validated for parameters as accuracy, repeatability, reproducibility, robustness, linearity, limit of detection and limit of quantification. This HPLC method was found to be specific, linear, precise,accurate, reproducible and robust and can be easily used for determination of common cough and cold analytes in a formulation as the results were found to be well within the acceptance range. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).HPLC of Formula: 132-20-7

The Article related to cough cold ingredient high performance liquid chromatog, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.HPLC of Formula: 132-20-7

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Raghu, M. S.; Basavaiah, K.; Prashanth, K. N.; Vinay, K. B. published an article in 2012, the title of the article was Acid-base titrimetric assay of pheniramine maleate in pharmaceuticals in hydro-alcoholic medium.Application of 132-20-7 And the article contains the following content:

Two simple titrimetric methods are described for the determination of pheniramine maleate (PAM) in pure form and in its dosage forms. The principle involved in the methods are simple acid-base reaction in which the carboxylic acid group of the drug was determined by titrating with an aqueous NaOH solution either visually using phenolphthalein as indicator (method A) or pH-metrically (method B) using glass-calomel electrode system. The methods were applicable over the range of 2-20 mg of PAM. The procedures were applied to the determination of PAM in tablets, injections, and the results were found to be in a good agreement with those obtained by the reference method. The precision results, expressed by intra-day and inter-day relative standard deviation values, were satisfactory (RSD ≤ 2.58%). The accuracy was satisfactory as well (RE ≤ 2.14%). Excipients used as additives in pharmaceutical formulations did not interfere in the proposed procedures as shown by placebo blank and synthetic mixture analyses and also by the recovery study via standard addition technique with percentage recoveries in the range 97.48 – 106.3% with a standard deviation of 1.76 – 3.42%. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application of 132-20-7

The Article related to pheniramine maleate determination acid base titrimetry, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Application of 132-20-7

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