Category: 132-20-7

Habyalimana, Vedaste; Mbinze, Jeremie Kindenge; Tshilombo, Nicodeme Kalenda; Dispas, Amandine; Loconon, Achille Yemoa; Sacre, Pierre-Yves; Widart, Joeelle; De Tullio, Pascal; Counerotte, Stephane; Ntokamunda, Justin-Leonard Kadima; Ziemons, Eric; Hubert, Philippe; Djang’eing’a, Roland Marini published an article in 2015, the title of the article was Analytical tools and strategic approach to detect poor quality medicines, identify unknown components, and timely alerts for appropriate measures: case study of antimalarial medicines.Synthetic Route of 132-20-7 And the article contains the following content:

Nowadays, the circulation of poor quality medicines is becoming an alarming worldwide phenomenon with serious public health and socio-economic concerns. The situation is particularly critical in developing countries where drug quality assurance and regulatory systems for drug manufacturing, importation, distribution and sales are weak. A sustained vigilance on poor quality medicines that regroup counterfeit/falsified, substandard and degraded medicines is therefore required to ensure patient safety and genuine medicines integrity. A case situation is illustrated including a strategic approach and anal. tools that were found useful to detect poor quality medicines, identify unknown components, and timely alerts for appropriate measures against the spread of those harmful products. Several suspected medicines randomly sampled in several strategic Rwandan areas were firstly check-controlled by means of visual inspection and then applying several anal. techniques from simple to more complex ones. The following medicines were studied: quinine sulfate tablets, artemisinin-based combination tablets, and artesunate powders for injection. Taking into account the pharmaceutical forms and the chem. characteristics, the following tests were applied: uniformity of mass, friability, disintegration, fluorescence, identification and assay. They were followed by more complex anal. techniques that allowed more comprehension of abnormal findings among which the presence of a wrong active pharmaceutical ingredient in quinine sulfate tablets which is mainly discussed in this paper to illustrate a strategic approach and various anal. tools that can be used in detecting and identifying unknown component in poor quality medicines. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Synthetic Route of 132-20-7

The Article related to antimalarial medicine drug quality assessment, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Synthetic Route of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sawant, Sakshi; Borkar, Nitin published an article in 2014, the title of the article was Method development of an simultaneous determination of common cough and cold ingredients by high performance liquid chromatography (HLPC) in multi component cough and cold oral drug products.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

A common simultaneous HPLC method has been developed for the quantification of common analytes used in cough and cold products. The seven analytes acetaminophen, guafenesin, pheniramine maleate, phenylephrine hydrochloride, diphenhydramine, chlorpheniramine maleate, dextromethorphan are separated out. HPLC separation was achieved on a C18 column with a gradient system optimized for all seven analytes with different chem. structures. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to cough cold high performance liquid chromatog, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Deconinck, E.; Sacre, P. Y.; Baudewyns, S.; Courselle, P.; De Beer, J. published an article in 2011, the title of the article was A fast ultra high pressure liquid chromatographic method for qualification and quantification of pharmaceutical combination preparations containing paracetamol, acetyl salicylic acid and/or antihistaminics.Recommanded Product: 132-20-7 And the article contains the following content:

A fully validated UHPLC method for the identification and quantification of pharmaceutical preparations, containing paracetamol and/or acetyl salicylic acid, combined with anti-histaminics (phenylephrine, pheniramine maleate, diphenhydramine, promethazine) and/or other additives as quinine sulfate, caffeine or codeine phosphate, was developed. The proposed method uses a Waters Acquity BEH C18 column (2 mm × 100 mm, 1.7 μm) with a gradient using an ammonium acetate buffer pH 4.0 as aqueous phase and methanol as organic modifier. The obtained method was fully validated based on its measurement uncertainty (accuracy profile) and robustness tests. Calibration lines for all components were linear within the studied ranges. The relative bias and the relative standard deviations for all components were resp. smaller than 1.5% and 2%, the β-expectation tolerance limits did not exceed the acceptance limits of 10% and the relative expanded uncertainties were smaller than 5% for all of the considered components. A UHPLC method was obtained for the identification and quantification of these kind of pharmaceutical preparations, which will significantly reduce anal. times and workload for the laboratories charged with the quality control of these preparations The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Recommanded Product: 132-20-7

The Article related to nsaid antihistaminic uplc quality control, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Recommanded Product: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 31, 2011, Raghu, M. S.; Basavaiah, K. published an article.Recommanded Product: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Two charge-transfer complexation reactions for spectrophotometric determination of pheniramine maleate using π-acceptors. And the article contained the following:

This study presents two simple, selective and rapid spectrophotometric methods for determination of pheniramine maleate (PAM) in pure form and in its formulations. Both methods are based on the formation of charge-transfer (CT) reaction of PAM with p-chloranilic acid (CAA) or 2,3-dichloro-5,6-dicyanoquinone (DDQ) in 1,4-dioxan-acetonitrile medium. CT complexes were quantified at 530 and 590 nm for CAA and DDQ methods, resp. Beer’s law is obeyed (concentrate ranges, 12.5-200 μg/mL-1 for CAA and 5-80 μg/mL-1 for DDQ method), with correlation coefficients (r) of 0.9999 and 0.9991. Apparent molar absorptivities are calculated to be 1.27 × 103 and 3.06 × 103 l/mol-1/cm-1, resp. and corresponding Sandell sensitivities are 0.281 and 0.112 μg/cm-2. Developed methods were successfully applied for determination of PAM in tablets and injections. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Recommanded Product: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to charge transfer complexation spectrophotometric determination pheniramine maleate pi acceptor, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Recommanded Product: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 2011, Murahdharan, Balathandapani; Gopu, Gopalakrishnan; Laya, Saraswathy; Vedhi, Chinnapiyan; Manisankar, Paramasivam published an article.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was A study on preparation and use of nano poly pyrrole and nano poly (3,4-ethylenedioxythiophene) coated glassy carbon electrode for the determination of antihistamine in pharmaceutical and urine sample. And the article contained the following:

Pheniramine maleate (PA), an antihistamine, was determined by Differential Pulse Stripping voltammetry using nano polypyrrole (Ppy) and nano poly (3,4-ethylenedioxythiophene) (PEDOT) modified glassy carbon electrodes. The cyclic voltammetric behavior of pheniramine was studied in aqueous acidic, neutral and alk. conditions. One well-defined oxidation peak was observed in the cyclic voltammograms at all pHs. The influence of pH, scan rate and concentration revealed irreversible electron transfer and the oxidation was diffusion controlled adsorption. The SEM anal. confirmed good accumulation of PA on the electrode surface. A systematic study of influence of various exptl. parameters that affect the stripping voltammetric response was carried out and the maximum peak current conditions were arrived at. Calibration was made under maximum peak current conditions. The range of study was 0.05 to 0.4 μg/mL on Ppy/GCE and 0.025 to 0.4 μg/mL on PEDOT/GCE and the lower limit of determination were 0.035 μg/mL on Ppy/GCE and 0.016 μg/mL on PEDOT/GCE. The suitability of the method for the determination of PA in pharmaceutical preparations and urine samples was also ascertained. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to polypyrrole ethylenedioxythiophene glassy carbon electrode nanoparticle antihistamine pheniramine maleate, Pharmacology: Drug Interactions and General Pharmacology and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaya Oeztuerk, Dilara; Baki, Birol; Oeztuerk, Recep; Karayuecel, Sedat; Uzun Goeren, Guelsen published an article in 2019, the title of the article was Determination of growth performance, meat quality and colour attributes of large rainbow trout (Oncorhynchus mykiss) in the southern Black Sea coasts of Turkey.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

The aim of this study was to determine the growth performance, meat quality and color attributes of large rainbow trout (Oncorhynchus mykiss) in net cage systems in the southern Black Sea coasts of Turkey. In the study, large rainbow trout with an initial weight of 1,322.07 ± 57.72 g were reached to 3,385.30 ± 140.98 g and the survival rates were 95.69 ± 1.32% in 5-mo production period. Crude protein and crude fat values of fish meat were ranged between 16.75 ± 0.07-20.18 ± 0.90% and 9.22 ± 0.15-12.29 ± 0.42%, resp. (p < .05). The essential and non-essential amino acid values were between 12.92 ± 0.02-13.09 ± 0.01 g/100 g and 11.97 ± 0.14-11.47 ± 0.01 g/100 g, resp. (p > .05). C20:5n-3, C22:6n-3, ɷ3 and ɷ6 values in fish meat were between 4.32 ± 0.02-4.30 ± 0.08% (p < .05), 8.31 ± 0.10-7.72 ± 0.15% (p < .05), 13.41 ± 0.10-12.93 ± 0.23% (p < .05) and 21.85 ± 0.06%-19.74 ± 0.36 (p < .05), resp. As a result, it can be concluded that large rainbow trout cultured in the southern Black Sea coasts of Turkey is a rich source of food in terms of fatty and amino acid compositions and atherogenicity index, thrombogenicity index and hypocholesterolemic/hypercholesterolemic values. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to meat food quality color amino acid oncorhynchus turkey, Food and Feed Chemistry: Meat, Eggs, Fish, and Seafood and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Raghu, M. S.; Basavaiah, K. published an article in 2012, the title of the article was Rapid and Sensitive Extraction-Free Spectrophotometric Methods for the Determination of Pheniramine Maleate Using Three Sulphonthalein Dyes.Formula: C20H24N2O4 And the article contains the following content:

Three extraction-free spectrophotometric methods which are simple, selective and sensitive are described for the quantitation of pheniramine maleate (PAM), an antiallergic drug, in pure form and in its formulations. The methods are based on formation of yellow colored ion-pair complexes between PAM and 3 sulfonthalein dyes viz., bromothymol blue (method A), and bromocresol purple (method B) in dichloromethane, and bromocresol green (method C) in chloroform medium. The exptl. variables such as reagent concentration, solvent medium and reaction time were carefully optimized to achieve the highest sensitivity. Beer’s law is obeyed over the concentration ranges 1.0-16.0 for method A and method B, and 0.6-12 μg ml-1 PAM for method C with correlation coefficient of 0.999 for method A and method B, and 0.997 for method C. The molar absorptivity values are calculated to be 2.3 × 104, 2.5 × 104 and 3.0 × 104 l mol-1 cm-1 for the methods in the same order. The composition of the ion-pairs was found to be 1:1 by Job’s method of continuous variations and the conditional stability constant (K f) of the complexes were calculated The proposed methods were applied successfully to the determination of PAM in tablets and injection with good accuracy and precision and without interferences from common additives. The results obtained by the proposed methods were compared favorably with those of the reference method. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Formula: C20H24N2O4

The Article related to pheniramine maleate determination spectrophotometry bromothymol blue bromocresol purple green, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Formula: C20H24N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 10, 2015, Tsakova, V.; Ilieva, G.; Filjova, D. published an article.Electric Literature of 132-20-7 The title of the article was Role of the anionic dopant of poly(3,4-ethylenedioxythiophene) for the electroanalytical performance: electrooxidation of acetaminophen. And the article contained the following:

Poly(3,4-ethylenedioxythiophene) (PEDOT) films were synthesized in the presence of various anions and surfactants (perchlorate, dodecylsulfate (DDS), polysterenesulfonate (PSS) and poly(2-acrylamido-2-methyl-1-propanesulfonate (PAMPS), and polyoxyethylene-10-laurylether (PLE))) on glassy C electrodes. The electrocatalytical activity for acetaminophen electrooxidation was studied depending on the type of dopant and the polymerization charge of the PEDOT films. All PEDOT-coated electrodes show a marked electrocatalytical effect for this reaction. After exposure to acetaminophen, a new redox pair is observed to appear in the voltammetric curves measured in supporting electrolyte for all PEDOT-coated electrodes. The dopant used in the PEDOT synthesis is found to play an important role for these redox currents with PEDOT/PSS-coated electrodes showing the smallest ones. The study of the role of the polymerization charge (i.e. the thickness of the polymer films) reveals that electrodes coated with thin PEDOT films perform better than those coated with thicker polymer films. Electroanal. detection of acetaminophen is effective by thin film PEDOT/PSS-coated electrodes. The concentration range of linear response is 50 μM dm-3 to 1 mM dm-3 in linear sweep voltammetry experiments and 5 μM dm-3 to 65 μM dm-3 in DPV experiments The corresponding LODs are 10 μM dm-3 and 0.3 μM dm-3, resp. PEDOT/PSS-coated electrodes were used to determine acetaminophen in four medications containing various addnl. components. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Electric Literature of 132-20-7

The Article related to anionic dopant polyethylenedioxythiophene electroanalytical determination electrooxidation acetaminophen, Electrochemistry: Electrodes, Electrode Reactions, and Electrode Potentials and other aspects.Electric Literature of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On February 28, 2011, Konstantopoulos, Nicky; Foletta, Victoria C.; Segal, David H.; Shields, Katherine A.; Sanigorski, Andrew; Windmill, Kelly; Swinton, Courtney; Connor, Tim; Wanyonyi, Stephen; Dyer, Thomas D.; Fahey, Richard P.; Watt, Rose A.; Curran, Joanne E.; Molero, Juan-Carlos; Krippner, Guy; Collier, Greg R.; James, David E.; Blangero, John; Jowett, Jeremy B.; Walder, Ken R. published an article.Synthetic Route of 132-20-7 The title of the article was A gene expression signature for insulin resistance. And the article contained the following:

Insulin resistance is a heterogeneous disorder caused by a range of genetic and environmental factors, and we hypothesize that its etiol. varies considerably between individuals. This heterogeneity provides significant challenges to the development of effective therapeutic regimes for long-term management of type 2 diabetes. We describe a novel strategy, using large-scale gene expression profiling, to develop a gene expression signature (GES) that reflects the overall state of insulin resistance in cells and patients. The GES was developed from 3T3-L1 adipocytes that were made “insulin resistant” by treatment with tumor necrosis factor-α (TNF-α) and then reversed with aspirin and troglitazone (“resensitized”). The GES consisted of five genes whose expression levels best discriminated between the insulin-resistant and insulin-resensitized states. We then used this GES to screen a compound library for agents that affected the GES genes in 3T3-L1 adipocytes in a way that most closely resembled the changes seen when insulin resistance was successfully reversed with aspirin and troglitazone. This screen identified both known and new insulin-sensitizing compounds including nonsteroidal anti-inflammatory agents, β-adrenergic antagonists, β-lactams, and sodium channel blockers. We tested the biol. relevance of this GES in participants in the San Antonio Family Heart Study (n = 1240) and showed that patients with the lowest GES scores were more insulin resistant (according to HOMA_IR and fasting plasma insulin levels; P < 0.001). These findings show that GES technol. can be used for both the discovery of insulin-sensitizing compounds and the characterization of patients into subtypes of insulin resistance according to GES scores, opening the possibility of developing a personalized medicine approach to type 2 diabetes. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Synthetic Route of 132-20-7

The Article related to gene expression signature insulin resistance, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Synthetic Route of 132-20-7

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vyas, Bhavesh M.; Singh, Adarsh J.; Dhattiwala, Abdulkadir S.; Mansuri, Sabera M.; Patel, Varsha J. published an article in 2014, the title of the article was Comparative CNS activities of clinically employed antihistamines (H1 antagonist).SDS of cas: 132-20-7 And the article contains the following content:

Aim: H1 Antihistamines are classified into first generation and second generation agents. The main differences between the first and second generations of drugs are their propensity to cause central nervous system (CNS) side effects. Therefore, present study was aimed to analyze the effects of different H1 antihistamines (first and second generation) on CNS using different animal exptl. models. Materials & methods: H1 antihistamines such as pheniramine maleate (3 mg/kg, 6 mg/kg), cetirizine (0.6 mg/kg, 1.2 mg/kg), levocetirizine (0.6mg/kg, 1.2 mg/kg), loratadine (1 mg/kg, 2 mg/kg) and desloratidine (0.6 mg/kg, 1.2 mg/kg) are evaluated and compared for their effects on CNS using exptl. animal model (Pentobarbitone sleeping time, spontaneous motor activity, motor co-ordination) in Swiss albino mice. Results & Discussion: Desloratadine (0.6mg/kg, 1.2 mg/kg) and loratadine (1 mg/kg, 2 mg/kg) did not produce significant (P < 0.05) effect on sleeping time when compared to control. At 120 min time interval after treatment with cetirizine (1.2 mg/kg) and levocetirizine (1.2 mg/kg) was shown reduction in locomotor activity and remaining three drugs such as pheniramine (6 mg/kg), loratadine (2 mg/kg) and desloratadine did produced any effect on locomotor activity. Treatment with higher dose of pheniramine (6 mg/kg) and cetirizine (1.2 mg/kg) was shown significant (P<0.05) motor coordination while other drugs did not induce any motor in-coordination. First generation antihistamines were shown significant effect on CNS activity at low and high dose while only some second generation antihistamines showed significant effect on CNS at high dose. Conclusion: Numerous well-performed, sensitive measures of psychomotor and cognitive performances are needed to study to compare the effect of first generation and second generation antihistamines on CNS to avoid serious impairment of CNS function. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).SDS of cas: 132-20-7

The Article related to pheniramine maleate cetirizine antihistamine motor activity coordination, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.SDS of cas: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem