Category: 132-20-7

On December 31, 2011, Balhara, Yatan Pal Singh; Jain, Raka; Dhawan, Anju; Mehta, Manju published an article.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was A comparative study of pheniramine and lorazepam for physiological and cognitive/psychomotor task impairment. And the article contained the following:

Context: Pheniramine is being used harmfully in combination with opiates and benzodiazepines through injecting route. Aims: The present study is an attempt to compare the physiol. and psychomotor/cognitive task performance on pheniramine and lorazepam. Settings and Design: The study used a double blind randomly allotted cross-over design. Materials and Methods: The doses of the drugs used were placebo (normal saline) – 2 mL, Pheniramine maleate – 45.5 mg, Lorazepam – 2 mg. The assessments were made at base line and then at 15 min, 120 min and 240 min. The subjects were assessed for the socio-demog. profile, drug use history, physiol. parameters (pulse rate, BP, respiratory rate), and psychomotor/cognitive tasks. Statistical Anal. Used: Anal. was carried out using SPSS ver 10.0. In between, drug comparisons were done using one-way ANOVA (multiple comparisons). Results: Physiol. and cognitive/psychomotor tasks performance did not show any significant difference between pheniramine, lorazepam and placebo. Conclusions: The findings suggest the pheniramine and lorazepam have comparable impairment on physiol. and cognitive/psychomotor task performance. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to pheniramine maleate lorazepam cognition psychomotor impairment drug addiction, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shravani, Bezawada; Anuradha, H. V.; Shivamurthy, M. C. published an article in 2017, the title of the article was Tramadol induced partial seizure: a rare adverse drug reaction – case report.Synthetic Route of 132-20-7 And the article contains the following content:

Tramadol is a synthetic codeine analog, acts at μ-opioid receptors (MOR) receptor and used to treat moderate pain with its onset of action being 10-15 min to 1 h and duration lasting upto 4-6 h. It inhibits uptake of norepinephrine and serotonin. It commonly causes vomiting, dry mouth sedation, very rarely seizures. Risk of seizure is more when used at high doses, abused for long time, used concomitantly with certain serotonergic or monoaminergic drugs and in patients with history of epilepsy. A 23 yr young unmarried female patient diagnosed as a case of Acute Pancreatitis and Systemic lupus erythematosis complained of severe low back pain and was prescribed one dose of Inj. Tramadol 50mg i.v. She developed jerky movements of the upper portion of her body involving the left arm and shoulder and uprolling of eye balls to one side after 10 min. This single episode lasted for about a minute and subsided thereafter immediately. Patient was conscious during the episode. No further such episodes noticed. No previous history of drug allergy or past and family history of seizures. No history of smoking, alc., drug abuse. No significant drug interactions were noted with inj. tramadol. This case illustrates that tramadol when used at low doses and without any predisposing risk factors as explained has the propensity to cause seizure. This reaction could be an idiosyncratic reaction. It alarms one to be more vigilant and monitor adverse reaction while prescribing various dose ranges of Tramadol. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Synthetic Route of 132-20-7

The Article related to partial seizure acute pancreatitis systemic lupus erythematosis tramadol delivery, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Synthetic Route of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 31, 2013, Beraki, Simret; Litrus, Lily; Soriano, Liza; Monbureau, Marie; To, Lillian K.; Braithwaite, Steven P.; Nikolich, Karoly; Urfer, Roman; Oksenberg, Donna; Shamloo, Mehrdad published an article.COA of Formula: C20H24N2O4 The title of the article was A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke. And the article contained the following:

With the availability and ease of small mol. production and design continuing to improve, robust, high-throughput methods for screening are increasingly necessary to find pharmacol. relevant compounds amongst the masses of potential candidates. Here, we demonstrate that a primary oxygen glucose deprivation assay in primary cortical neurons followed by secondary assays (i.e. post-treatment protocol in organotypic hippocampal slice cultures and cortical neurons) can be used as a robust screen to identify neuroprotective compounds with potential therapeutic efficacy. In our screen about 50% of the compounds in a library of pharmacol. active compounds displayed some degree of neuroprotective activity if tested in a pre-treatment toxicity assay but just a few of these compounds, including Carbenoxolone, remained active when tested in a post-treatment protocol. When further examined, Carbenoxolone also led to a significant reduction in infarction size and neuronal damage in the ischemic penumbra when administered six hours post middle cerebral artery occlusion in rats. Pharmacol. testing of Carbenoxolone-related compounds, acting by inhibition of 11-β-hydroxysteroid dehydrogenase-1 (11β-HSD1), gave rise to similarly potent in vivo neuroprotection. This indicates that the increase of intracellular glucocorticoid levels mediated by 11β-HSD1 may be involved in the mechanism that exacerbates ischemic neuronal cell death and inhibiting this enzyme could have potential therapeutic value for neuroprotective therapies in ischemic stroke and other neurodegenerative disorders associated with neuronal injury. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).COA of Formula: C20H24N2O4

The Article related to ischemic stroke drug discovery screening neuroprotectant carbenoxolone brain injury, beta hydroxysteroid dehydrogenase, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.COA of Formula: C20H24N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 10, 2015, Tsakova, V.; Ilieva, G.; Filjova, D. published an article.Electric Literature of 132-20-7 The title of the article was Role of the anionic dopant of poly(3,4-ethylenedioxythiophene) for the electroanalytical performance: electrooxidation of acetaminophen. And the article contained the following:

Poly(3,4-ethylenedioxythiophene) (PEDOT) films were synthesized in the presence of various anions and surfactants (perchlorate, dodecylsulfate (DDS), polysterenesulfonate (PSS) and poly(2-acrylamido-2-methyl-1-propanesulfonate (PAMPS), and polyoxyethylene-10-laurylether (PLE))) on glassy C electrodes. The electrocatalytical activity for acetaminophen electrooxidation was studied depending on the type of dopant and the polymerization charge of the PEDOT films. All PEDOT-coated electrodes show a marked electrocatalytical effect for this reaction. After exposure to acetaminophen, a new redox pair is observed to appear in the voltammetric curves measured in supporting electrolyte for all PEDOT-coated electrodes. The dopant used in the PEDOT synthesis is found to play an important role for these redox currents with PEDOT/PSS-coated electrodes showing the smallest ones. The study of the role of the polymerization charge (i.e. the thickness of the polymer films) reveals that electrodes coated with thin PEDOT films perform better than those coated with thicker polymer films. Electroanal. detection of acetaminophen is effective by thin film PEDOT/PSS-coated electrodes. The concentration range of linear response is 50 μM dm-3 to 1 mM dm-3 in linear sweep voltammetry experiments and 5 μM dm-3 to 65 μM dm-3 in DPV experiments The corresponding LODs are 10 μM dm-3 and 0.3 μM dm-3, resp. PEDOT/PSS-coated electrodes were used to determine acetaminophen in four medications containing various addnl. components. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Electric Literature of 132-20-7

The Article related to anionic dopant polyethylenedioxythiophene electroanalytical determination electrooxidation acetaminophen, Electrochemistry: Electrodes, Electrode Reactions, and Electrode Potentials and other aspects.Electric Literature of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On February 28, 2011, Konstantopoulos, Nicky; Foletta, Victoria C.; Segal, David H.; Shields, Katherine A.; Sanigorski, Andrew; Windmill, Kelly; Swinton, Courtney; Connor, Tim; Wanyonyi, Stephen; Dyer, Thomas D.; Fahey, Richard P.; Watt, Rose A.; Curran, Joanne E.; Molero, Juan-Carlos; Krippner, Guy; Collier, Greg R.; James, David E.; Blangero, John; Jowett, Jeremy B.; Walder, Ken R. published an article.Synthetic Route of 132-20-7 The title of the article was A gene expression signature for insulin resistance. And the article contained the following:

Insulin resistance is a heterogeneous disorder caused by a range of genetic and environmental factors, and we hypothesize that its etiol. varies considerably between individuals. This heterogeneity provides significant challenges to the development of effective therapeutic regimes for long-term management of type 2 diabetes. We describe a novel strategy, using large-scale gene expression profiling, to develop a gene expression signature (GES) that reflects the overall state of insulin resistance in cells and patients. The GES was developed from 3T3-L1 adipocytes that were made “insulin resistant” by treatment with tumor necrosis factor-α (TNF-α) and then reversed with aspirin and troglitazone (“resensitized”). The GES consisted of five genes whose expression levels best discriminated between the insulin-resistant and insulin-resensitized states. We then used this GES to screen a compound library for agents that affected the GES genes in 3T3-L1 adipocytes in a way that most closely resembled the changes seen when insulin resistance was successfully reversed with aspirin and troglitazone. This screen identified both known and new insulin-sensitizing compounds including nonsteroidal anti-inflammatory agents, β-adrenergic antagonists, β-lactams, and sodium channel blockers. We tested the biol. relevance of this GES in participants in the San Antonio Family Heart Study (n = 1240) and showed that patients with the lowest GES scores were more insulin resistant (according to HOMA_IR and fasting plasma insulin levels; P < 0.001). These findings show that GES technol. can be used for both the discovery of insulin-sensitizing compounds and the characterization of patients into subtypes of insulin resistance according to GES scores, opening the possibility of developing a personalized medicine approach to type 2 diabetes. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Synthetic Route of 132-20-7

The Article related to gene expression signature insulin resistance, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Synthetic Route of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vyas, Bhavesh M.; Singh, Adarsh J.; Dhattiwala, Abdulkadir S.; Mansuri, Sabera M.; Patel, Varsha J. published an article in 2014, the title of the article was Comparative CNS activities of clinically employed antihistamines (H1 antagonist).SDS of cas: 132-20-7 And the article contains the following content:

Aim: H1 Antihistamines are classified into first generation and second generation agents. The main differences between the first and second generations of drugs are their propensity to cause central nervous system (CNS) side effects. Therefore, present study was aimed to analyze the effects of different H1 antihistamines (first and second generation) on CNS using different animal exptl. models. Materials & methods: H1 antihistamines such as pheniramine maleate (3 mg/kg, 6 mg/kg), cetirizine (0.6 mg/kg, 1.2 mg/kg), levocetirizine (0.6mg/kg, 1.2 mg/kg), loratadine (1 mg/kg, 2 mg/kg) and desloratidine (0.6 mg/kg, 1.2 mg/kg) are evaluated and compared for their effects on CNS using exptl. animal model (Pentobarbitone sleeping time, spontaneous motor activity, motor co-ordination) in Swiss albino mice. Results & Discussion: Desloratadine (0.6mg/kg, 1.2 mg/kg) and loratadine (1 mg/kg, 2 mg/kg) did not produce significant (P < 0.05) effect on sleeping time when compared to control. At 120 min time interval after treatment with cetirizine (1.2 mg/kg) and levocetirizine (1.2 mg/kg) was shown reduction in locomotor activity and remaining three drugs such as pheniramine (6 mg/kg), loratadine (2 mg/kg) and desloratadine did produced any effect on locomotor activity. Treatment with higher dose of pheniramine (6 mg/kg) and cetirizine (1.2 mg/kg) was shown significant (P<0.05) motor coordination while other drugs did not induce any motor in-coordination. First generation antihistamines were shown significant effect on CNS activity at low and high dose while only some second generation antihistamines showed significant effect on CNS at high dose. Conclusion: Numerous well-performed, sensitive measures of psychomotor and cognitive performances are needed to study to compare the effect of first generation and second generation antihistamines on CNS to avoid serious impairment of CNS function. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).SDS of cas: 132-20-7

The Article related to pheniramine maleate cetirizine antihistamine motor activity coordination, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.SDS of cas: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 31, 2013, Beraki, Simret; Litrus, Lily; Soriano, Liza; Monbureau, Marie; To, Lillian K.; Braithwaite, Steven P.; Nikolich, Karoly; Urfer, Roman; Oksenberg, Donna; Shamloo, Mehrdad published an article.COA of Formula: C20H24N2O4 The title of the article was A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke. And the article contained the following:

With the availability and ease of small mol. production and design continuing to improve, robust, high-throughput methods for screening are increasingly necessary to find pharmacol. relevant compounds amongst the masses of potential candidates. Here, we demonstrate that a primary oxygen glucose deprivation assay in primary cortical neurons followed by secondary assays (i.e. post-treatment protocol in organotypic hippocampal slice cultures and cortical neurons) can be used as a robust screen to identify neuroprotective compounds with potential therapeutic efficacy. In our screen about 50% of the compounds in a library of pharmacol. active compounds displayed some degree of neuroprotective activity if tested in a pre-treatment toxicity assay but just a few of these compounds, including Carbenoxolone, remained active when tested in a post-treatment protocol. When further examined, Carbenoxolone also led to a significant reduction in infarction size and neuronal damage in the ischemic penumbra when administered six hours post middle cerebral artery occlusion in rats. Pharmacol. testing of Carbenoxolone-related compounds, acting by inhibition of 11-β-hydroxysteroid dehydrogenase-1 (11β-HSD1), gave rise to similarly potent in vivo neuroprotection. This indicates that the increase of intracellular glucocorticoid levels mediated by 11β-HSD1 may be involved in the mechanism that exacerbates ischemic neuronal cell death and inhibiting this enzyme could have potential therapeutic value for neuroprotective therapies in ischemic stroke and other neurodegenerative disorders associated with neuronal injury. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).COA of Formula: C20H24N2O4

The Article related to ischemic stroke drug discovery screening neuroprotectant carbenoxolone brain injury, beta hydroxysteroid dehydrogenase, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.COA of Formula: C20H24N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shravani, Bezawada; Anuradha, H. V.; Shivamurthy, M. C. published an article in 2017, the title of the article was Tramadol induced partial seizure: a rare adverse drug reaction – case report.Synthetic Route of 132-20-7 And the article contains the following content:

Tramadol is a synthetic codeine analog, acts at μ-opioid receptors (MOR) receptor and used to treat moderate pain with its onset of action being 10-15 min to 1 h and duration lasting upto 4-6 h. It inhibits uptake of norepinephrine and serotonin. It commonly causes vomiting, dry mouth sedation, very rarely seizures. Risk of seizure is more when used at high doses, abused for long time, used concomitantly with certain serotonergic or monoaminergic drugs and in patients with history of epilepsy. A 23 yr young unmarried female patient diagnosed as a case of Acute Pancreatitis and Systemic lupus erythematosis complained of severe low back pain and was prescribed one dose of Inj. Tramadol 50mg i.v. She developed jerky movements of the upper portion of her body involving the left arm and shoulder and uprolling of eye balls to one side after 10 min. This single episode lasted for about a minute and subsided thereafter immediately. Patient was conscious during the episode. No further such episodes noticed. No previous history of drug allergy or past and family history of seizures. No history of smoking, alc., drug abuse. No significant drug interactions were noted with inj. tramadol. This case illustrates that tramadol when used at low doses and without any predisposing risk factors as explained has the propensity to cause seizure. This reaction could be an idiosyncratic reaction. It alarms one to be more vigilant and monitor adverse reaction while prescribing various dose ranges of Tramadol. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Synthetic Route of 132-20-7

The Article related to partial seizure acute pancreatitis systemic lupus erythematosis tramadol delivery, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Synthetic Route of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 31, 2011, Balhara, Yatan Pal Singh; Jain, Raka; Dhawan, Anju; Mehta, Manju published an article.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was A comparative study of pheniramine and lorazepam for physiological and cognitive/psychomotor task impairment. And the article contained the following:

Context: Pheniramine is being used harmfully in combination with opiates and benzodiazepines through injecting route. Aims: The present study is an attempt to compare the physiol. and psychomotor/cognitive task performance on pheniramine and lorazepam. Settings and Design: The study used a double blind randomly allotted cross-over design. Materials and Methods: The doses of the drugs used were placebo (normal saline) – 2 mL, Pheniramine maleate – 45.5 mg, Lorazepam – 2 mg. The assessments were made at base line and then at 15 min, 120 min and 240 min. The subjects were assessed for the socio-demog. profile, drug use history, physiol. parameters (pulse rate, BP, respiratory rate), and psychomotor/cognitive tasks. Statistical Anal. Used: Anal. was carried out using SPSS ver 10.0. In between, drug comparisons were done using one-way ANOVA (multiple comparisons). Results: Physiol. and cognitive/psychomotor tasks performance did not show any significant difference between pheniramine, lorazepam and placebo. Conclusions: The findings suggest the pheniramine and lorazepam have comparable impairment on physiol. and cognitive/psychomotor task performance. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to pheniramine maleate lorazepam cognition psychomotor impairment drug addiction, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pham, Ngoc H.; Wenzel, Thomas J. published an article in 2011, the title of the article was A sulfonated calix[4]resorcinarene with α-methyl-L-prolinylmethyl groups as a water-soluble chiral NMR solvating agent.Category: pyridine-derivatives And the article contains the following content:

A water-soluble calix[4]resorcinarene containing α-methyl-L-prolinylmethyl groups was investigated as a chiral NMR solvating agent. Substrates form complexes by insertion of the aromatic ring into the cavity of the calix[4]resorcinarene. Amino acid derivatives with Ph or indole rings, ammonium substrates with pyridyl, indane or dihydroindole rings, and phenyl-containing substrates with carboxylic acid and/or hydroxyl groups were studied. The effectiveness of the α-methyl-L-prolinylmethyl calix[4]resorcinarene is compared to similar reagents with proline and hydroxyproline moieties that have previously been reported. The α-methyl-L-prolinylmethyl derivative causes larger enantiomeric discrimination of one or more 1H resonances than the previous systems for most of the substrates. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Category: pyridine-derivatives

The Article related to chiral nmr solvating agent sulfonated calixarene prolinylmethyl derivative, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem