Synthetic Route of 132097-09-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.132097-09-7, name is 2,4-Dichloro-3-methylpyridine, molecular formula is C6H5Cl2N, molecular weight is 162.02, as common compound, the synthetic route is as follows.
4-HYDROXY-PIPERIDINE-1-CARBOXYLIC acid isopropyl ester (0.496 mL, 2. 90 mmol) was dissolved in anhydrous DIMETHYLACETAMIDE (DMA, 5 mL), NaH (60% oil dispersion, 116 mg, 2.90 mmol) was added and this mixture was stirred at 23C for 45 min, then this mixture was added dropwise to 2,4- dichloro-3-methyl-pyridine, which was dissolved in anhydrous DMA (4 mL). This mixture was stirred at 23 OC for 2 h then heated at 50C for 15 h, after which time the mixture was diluted with ET20 (140 mL), washed with water (14 mL), then brine twice (2 x 14 mL). The organic layer was separated, dried with MGS04, and the solvent was evaporated in vacuo to give an oil which was purified by flash chromatography using hexanes-EtOAc, 75: 25, V/V, then hexanes-EtOAc, 50: 50, V/V, to give 4-(2-chloro-3-methyl-pyridin-4-yloxy)-piperidine-1-carboxylic acid isopropyl ester as a solid (223 mg, 27%). H NMR (CDC13, 400 MHz) No. 8.09 (d, 1H), 6.69 (d, 1H), 4.91 (M, 1H), 4. 60 (M, 1H), 3.61 (M, 2H), 3.52 (M, 2H), 2.24 (s, 3H), 1.91 (M, 2H), 1.80 (M, 2H), 1.24 d, 6H). LRMS calculated for C15H21CIN203 : 312.12, Found: (MH) + 313. 4.
The chemical industry reduces the impact on the environment during synthesis 132097-09-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; WO2005/7647; (2005); A1;,
Pyridine – Wikipedia,
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