As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 132213-07-1, name is Imidazo[1,2-a]pyridin-6-ylmethanol, molecular formula is C8H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of Imidazo[1,2-a]pyridin-6-ylmethanol
Q. TH-1435 To a O0C solution of imidazo[l,2-a]pyridinyl-6-methanol (76 mg, 0.51 mmol), TH- 1152 (150 mg, 0.34 mmol), and PPh3 (134 mg, 0.51 mmol), in anhydrous toluene (1.5 mL) was added DIAD (103 muL, 0.51 mmol). The reaction mixture was stirred for 5 min, allowed to come to RT, stirred 3h, silica was added to it and volatiles removed. The residue was purified by column chromatography using 2:1 Hexanes/DCM to 20% acetone/DCM a second column 0-50% acetone/toluene. The residue was triturated with EtOAc to provide TH-1435 as a yellow crystalline solid (65 mg). 1H NMR (400 MHz, CDCl3) delta 7.74 (d, J = 2.2 Hz, IH), 7.55 (dd, J= 16.2, 5.7 Hz, 2H), 7.29 (dd, J= 8.6, 2.4 Hz, IH), 6.99 (d, J= 9.2 Hz, 2H), 6.64 (d, J= 8.5 Hz, IH), 6.60 (d, J= 9.2 Hz, 2H), 6.18 (dd, J= 11.0, 4.4 Hz, IH),
With the rapid development of chemical substances, we look forward to future research findings about 132213-07-1.
Reference:
Patent; THRESHOLD PHARMACEUTICALS, INC.; WO2009/140553; (2009); A2;,
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