Category: 13228-40-5

Reference of 13228-40-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13228-40-5, name is 2-(2-Pyridyl)indole. A new synthetic method of this compound is introduced below.

Step 3: To a solution of 16 (1.6 g, 8.24 [MMOL) IN ACOH] (30 ml) at 80 [C] was added 4-piperidone hydrochloride (3.7 g, 23.9 [MMOL)] and [H3PO4] (10 [ML).] The reaction was stirred at this temperature for 72 h and at [100] C for 24 h. The reaction was cooled to RT and poured into [ICE/NH40H] and extracted with EtOAc. The combined organic layers were washed with water and brine, dried [(NA2SO4)] and concentrated. The residue was purified on a flash column (20% EtOAc in hexane to 10% CH30H/NH3 in [CH2CI2)] to give 17 (0.5 g, 44% based on recovered starting material). MS (M+H) [=] 276.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13228-40-5, its application will become more common.

Reference:
Patent; SCHERING CORPORATION; WO2004/831; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 13228-40-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13228-40-5, name is 2-(2-Pyridyl)indole, molecular formula is C13H10N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2 – (piperidin – 2 – yl) – 1 H – indoleAt room temperature, the compound 6 c (0.5 g, 2 . 57 mmol) dissolved in acetic acid (10 ml), then two platinum oxide (0.116 g, 0 . 514 mmol) is added to the reaction, vacuum, hydrogen replacement for three times, the hydrogen in the lower, 50 C stirring reaction for 4 hours. The reaction liquid filtering, turns on lathe does, then with saturated sodium bicarbonate solution to regulate pH ? 8, aqueous phase methylene chloride (30 ml × 3) extraction, the combined organic phase with saturated salt water (50 ml) washing, anhydrous sodium sulfate drying, filtering, turns on lathe does to obtain a yellow solid compound 6 d (0.35 g, yield: 68%).

According to the analysis of related databases, 13228-40-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Fan Jiang; Wei Yonggang; Liu Zhenhong; Qin Linlin; (65 pag.)CN106928126; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13228-40-5, name is 2-(2-Pyridyl)indole, molecular formula is C13H10N2, molecular weight is 194.2319, as common compound, the synthetic route is as follows.Safety of 2-(2-Pyridyl)indole

General procedure: A sealed tube was charged with 4 (0.20 mmol), 2 (0.30 mmol), CeCl3·7H2O (0.02 mmol). Then 2 ml of ethanol was added to the reaction system. The reaction mixture was stirred at 120 C. The reaction was monitored by TLC until the 4 was completely consumed (about 12h). The solvent was removed under reduced pressure. The residue was purified through column chromatography using silica gel to give 5.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13228-40-5, 2-(2-Pyridyl)indole, and friends who are interested can also refer to it.

Reference:
Article; Feng, Cheng-Tao; Zhu, Hui-Zhi; Li, Zhong; Luo, Zaigang; Wu, Song-Song; Ma, Shi-Tang; Tetrahedron Letters; vol. 57; 7; (2016); p. 800 – 803;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 13228-40-5 ,Some common heterocyclic compound, 13228-40-5, molecular formula is C13H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A sealed tube was charged with 4 (0.20 mmol), 2 (0.30 mmol), CeCl3¡¤7H2O (0.02 mmol). Then 2 ml of ethanol was added to the reaction system. The reaction mixture was stirred at 120 C. The reaction was monitored by TLC until the 4 was completely consumed (about 12h). The solvent was removed under reduced pressure. The residue was purified through column chromatography using silica gel to give 5.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13228-40-5, 2-(2-Pyridyl)indole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Feng, Cheng-Tao; Zhu, Hui-Zhi; Li, Zhong; Luo, Zaigang; Wu, Song-Song; Ma, Shi-Tang; Tetrahedron Letters; vol. 57; 7; (2016); p. 800 – 803;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem