Category: 132606-40-7

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 132606-40-7, name is 5-Bromo-2-chloro-6-methylpyridine, the common compound, a new synthetic route is introduced below. name: 5-Bromo-2-chloro-6-methylpyridine

To a stirred solution of 3-bromo-6-c oro-2-me1hylpyridine (105 g, 509 mmol) in CCI4 (2 L) was added N-bromosuccinimide (95 g, 534 mmol) followed by AIBN (8.35 g, 50.9 mmol). The reaction was brought to reflux for 24 hours and then cooled to r.t, filtered, and concentrated. Purification of the residue by flash chromatography on silica gel with 60% methylene chloride heptanes afforded 144.7 g of semi-pure product. Further purification by SFC on a Chiralpak AD-H column with 20% IPA/CO2 [the conditions of the preparative separation were as follows: column Chiralpak AD-H (2.1×25 cm, 5 um particle size) (Chiral Technologies, West Chester, PA, USA); mobile phase 20% 2-propanol/C02; elution mode isocratic pump-mixed; flow rate 50 mL rnin; pressure 100 bar.] gave 3-bromo-2-(bromomethyl)-6-cMoropyridine.LCMS – 285.7 (M+l)+ *H NMR (CDC13> 500 MHz) delta 7.81 (d, J= 8.4 Hz, 1H), 7.15 (d, J= 8.3 Hz, 1H), 4.63 (s, 2H).

The synthetic route of 132606-40-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; THOMPSON, Christopher, F.; SWEIS, Ramzi, F.; WO2011/28395; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 132606-40-7, name is 5-Bromo-2-chloro-6-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 132606-40-7

3-Bromo-6-chloro-2-methylpyridine (200 mg, 0.969 mmol), tert-butyl (2-oxopiperidin-4-yl)carbamate (249 mg, 1.162 mmol), Pd2(dba)3(89 mg, 0.0972 mmol), Xantphos (112 mg, 0.194 mmol), cesium carbonate (947 mg, 2.907 mmol) were stirred in dioxane (10 mL) overnight at 100C under nitrogen, cooled and concentrated to give the product after column chromatography ( 31 mg, yield 9.4%).

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Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Liu Shiqiang; Zhou Yuanfeng; Liu Lei; Bao Rudi; (47 pag.)CN107793399; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem