In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 132865-44-2, name is 5-Chloro-6-methoxynicotinaldehyde, the common compound, a new synthetic route is introduced below. Computed Properties of C7H6ClNO2
A mixture of 5-chloro-6-methoxynicotinaldehyde (59.56 mg, 0.347 1 mmol), 4-(2-(3,6- diazabicyclo[3. 1.1 ]heptan-3 -yl)pyrimidin-5 -yl)-6-(2-morpholinoethoxy)pyrazolo[ 1,5 -a]pyridine3-carbonitrile (Intermediate P117; 31 mg, 0.069 mmol) and NaBH(AcO)3 (147.1 mg, 0.6943 mmol) in DCM (694.3 tL) was stirred overnight at ambient temperature. The reaction mixture was purified directly by silica chromatography (using 0-10% MeOH in EtOAc with 0.1% NH4OH as the gradient eluent) to cleanly afford the title compound (15.19 mg, 35% yield). MS (apci) m/z = 602.3 (M+H).
The synthetic route of 132865-44-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; TANG, Tony P.; REN, Li; (668 pag.)WO2018/71447; (2018); A1;,
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