Category: 133081-24-0

Related Products of 133081-24-0 ,Some common heterocyclic compound, 133081-24-0, molecular formula is C6H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Water was purified and deionized (18 MOmega/cm2) via a Milli-Q water filtration system (Millipore Corp., Milford, MA). 99Mo-99mTc generators were purchased from TecnoNuclear (Argentina). High performance liquid chromatography (HPLC) was performed on an HPLC Varian 5000 Liquid Chromatograph, integrator 4290 Varian, simultaneous detection by NaI (Tl) crystal detector (ORTEC)) and UV detector (lambda= 254 nm), Column Thermo Scientific Hypersil ODS (C18) (300 mm × 4.6 × 10 mum). The flow rate was 1mL/min used with a gradient mobile phase from 100% of A (0.1% TFA in H2O) to 100% of B (0.1% TFA in acetonitrile) in 20 min. Labeling conditions: 1 mL of HYNIC-hydrazone in DMSO (1mg/mL) was incubated with 0.4 mL of tricine solution (100 mg/mL in water), 0.2 mL nicotinic acid solution (10 mg/ml in water), 100 muL of 99mTcO4- (37-111 MBq) and 15 muL of SnCl2.2H2O (1 mg/mL in nitrogen-purged 0.1 M HCl) for 60 min at 70 oC tofinal pH 5. The reaction was analyzed for radiochemical purity by HPLC. CPS: counts per second.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 133081-24-0, 6-Hydrazinylnicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Teixeira, Vania; Cabral, Pablo; Porcal, Williams; Arkivoc; vol. 2018; 5; (2018); p. 29 – 38;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 133081-24-0 ,Some common heterocyclic compound, 133081-24-0, molecular formula is C6H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

6-chloronicotinic acid (1.6 g ) in MeOH (1OmL) was treated with NH2NH2 (2 g) at 140 0C for 2h. After cooling to -20 0C, the solid was filtered to give 560mg of compound 33B. Compound 33B was treated with isothiocyanatobenzene (141 mg) in 1 ,2-dichlorobenzene (5 mL) at 100 0C for 10 min, and then 180 0C for Ih. The product was purified by LCMS to give 3-mercapto- [l,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid (450mg). ESI-MS:m/z 196.1 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 133081-24-0, 6-Hydrazinylnicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; BRESSI, Jerome, C.; CHU, Shaosong; ERICKSON, Philip; KOMANDLA, Mallareddy; KWOK, Lily; LAWSON, John, D.; STAFFORD, Jeffrey, A.; WALLACE, Michael, B.; ZHANG, Zhiyuan; DAS, Sanjib; WO2010/19899; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 133081-24-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.133081-24-0, name is 6-Hydrazinylnicotinic acid, molecular formula is C6H7N3O2, molecular weight is 153.14, as common compound, the synthetic route is as follows.

General procedure: A 0.5M solution of 2-chloropyridine-5-carboxylic acid (15 mmol) was treated with hydrazine hydrate (150 mmol, added at once) and heated at reflux for 72 h. The suspension was concentrated to dryness. The residue was dissolved in water and acidified (pH = 3) with acetic acid. The precipitate of 2-hydrazinopyridine-5-carboxylic acid that formed in 15 min was filtered off, washed with water and air-dried. It was dissolved in the respective aliphatic carboxylic acid and the solution (0.5M) was heated at reflux for 48 h. Upon cooling to room temperature, the volatiles were removed in vacuo and the residue was triturated with 1M aqueous sodium bicarbonate. The precipitate thus formed was filtered off, washed with water and air dried. The resulting 1,2,4-triazolo[4,3-a]pyridine 12 was dissolved in methanol (0.25M and was hydrogenated over Pd(OH)2 catalyst (0.1 equiv.) at 100 atm and 100 C over 24 hours. The mixture was filtered while still hot and concentrated in vacuo. The residue was crystallized from isopropyl alcohol to provide analytically pure carboxylic acids 11a-d.

Statistics shows that 133081-24-0 is playing an increasingly important role. we look forward to future research findings about 6-Hydrazinylnicotinic acid.

Reference:
Article; Mishchuk, Alexander; Shtil, Natalia; Poberezhnyk, Mykola; Nazarenko, Konstiantyn; Savchenko, Timur; Tolmachev, Andrey; Krasavin, Mikhail; Tetrahedron Letters; vol. 57; 9; (2016); p. 1056 – 1059;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 133081-24-0, Adding some certain compound to certain chemical reactions, such as: 133081-24-0, name is 6-Hydrazinylnicotinic acid,molecular formula is C6H7N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 133081-24-0.

A solution of DOTA tri-t-butyl ester (225 mg, 0.393 mmol), HOBt (50 mg, 0.33 mmol), and EDC (62 mg, 0.32 mmol) in 50:50 dichloromethane:acetonitrile (2.0 mL) was stirred at ambient temperatures under nitrogen for 5 minutes, and treated with 6-hydrazinictoic acid (50 mg, 0.32 mmol). The solution was stirred for 60 hours and concentrated under reduced pressure. The residue was purified by HPLC on a Phenomenex Luna Cl 8 column (21.2 x 250 mm) using a 0.9%/min gradient of 9 to 36% acetonitrile containing 0.1% TFA at a flow rate of 20 niL/min. The main product peak eluting at 32.9 minutes was lyophilized to give the title compound as an off-white solid (3.0 mg, 1.0%). MS (ESI): 708.4 (60, M+H).

According to the analysis of related databases, 133081-24-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB PHARMA COMPANY; WO2007/5491; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 133081-24-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 133081-24-0, name is 6-Hydrazinylnicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

Preparation 47 6-(4-(4-cyano-2-methoxyphenyl)-5-hydroxy-lH-pyrazol-l- yl)nicotinic acid [0229] Combined ethyl 2-(4-cyano-2-methoxyphenyl)-3-(dimethylamino)acrylate (1.427 g, 5.20 mmol), 6-hydrazinylnicotinic acid (0.664 g, 4.34 mmol), and HCl (4.34 mL, 4.34 mmol) in 2-propanol (21.7 mL) and stirred at room temperature for 8 hours to give a solid. The solid was collected by filtration and combined with Hunig’s base (1.50 mL, 8.61 mmol) in 2- propanol (10 mL) and water (1 mL) and stirred for 32 hours at 50C, then 10 mL of 1 N HCl was added and the reaction was filtered to give a solid. The solid was washed with 30 mL MeOH and 30 mL of ether and dried in vacuo to give the title compound (708 mg, 73.3%) as a beige solid. MS m/z [M+H]+ 337.3.

According to the analysis of related databases, 133081-24-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; BROWN, Jason, W.; DAVIS, Melinda; IVETAC, Anthony; JONES, Benjamin; KIRYANOV, Andre, A.; KUEHLER, Jon; LANIER, Marion; MIURA, Joanne; MURPHY, Sean; WANG, Xiaolun; WO2014/160810; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 133081-24-0, Adding some certain compound to certain chemical reactions, such as: 133081-24-0, name is 6-Hydrazinylnicotinic acid,molecular formula is C6H7N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 133081-24-0.

(5) Dissolving the product 4 in ethanol at a concentration of 0.002 g/mL. then, 6-hydrazinonicotinic acid was added, the concentration was 0.002 g/mL, and after mixing, 2 to 3 drops of glacial acetic acid were added, and the mixture was refluxed for 3.5 hours. The solvent was concentrated under reduced pressure, and the dark yellow solid was solidified, and the solid was purified by recrystallization. After obtaining a golden yellow flocculent crystal, a high fluorescence quantum yield two-photon Zn2+ detection fluorescent molecular probe is obtained.

According to the analysis of related databases, 133081-24-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Qufu Normal University; Chen Guang; Zhao Guanghui; Jiang Ao; Li Zhen; Hu Jinlian; Liu Zhenjun; You Jinmao; (15 pag.)CN109761965; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 133081-24-0, 6-Hydrazinylnicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H7N3O2, blongs to pyridine-derivatives compound. HPLC of Formula: C6H7N3O2

General procedure: A 0.5M solution of 2-chloropyridine-5-carboxylic acid (15 mmol) was treated with hydrazine hydrate (150 mmol, added at once) and heated at reflux for 72 h. The suspension was concentrated to dryness. The residue was dissolved in water and acidified (pH = 3) with acetic acid. The precipitate of 2-hydrazinopyridine-5-carboxylic acid that formed in 15 min was filtered off, washed with water and air-dried. It was dissolved in the respective aliphatic carboxylic acid and the solution (0.5M) was heated at reflux for 48 h. Upon cooling to room temperature, the volatiles were removed in vacuo and the residue was triturated with 1M aqueous sodium bicarbonate. The precipitate thus formed was filtered off, washed with water and air dried. The resulting 1,2,4-triazolo[4,3-a]pyridine 12 was dissolved in methanol (0.25M and was hydrogenated over Pd(OH)2 catalyst (0.1 equiv.) at 100 atm and 100 C over 24 hours. The mixture was filtered while still hot and concentrated in vacuo. The residue was crystallized from isopropyl alcohol to provide analytically pure carboxylic acids 11a-d.

The synthetic route of 133081-24-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mishchuk, Alexander; Shtil, Natalia; Poberezhnyk, Mykola; Nazarenko, Konstiantyn; Savchenko, Timur; Tolmachev, Andrey; Krasavin, Mikhail; Tetrahedron Letters; vol. 57; 9; (2016); p. 1056 – 1059;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem