Category: 13362-30-6

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13362-30-6, name is Ethyl 2-aminoisonicotinate, the common compound, a new synthetic route is introduced below. Product Details of 13362-30-6

Example 97 Preparation of ethyl 2-valeramidoisonicotinate ([9]-(94)-467) The compound ([9]-(93)-467′) (2.0691 g) prepared in Example 96 was dissolved in anhydrous pyridine (25 ml), and valeryl chloride (1.5 ml) was added dropwise to the solution with stirring and cooling on ice. After stirring and cooling on ice for 1 hour, the reaction solution was poured into ice water. The solution was extracted with ethyl acetate, washed with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated. The resulting light yellow oil (3.2548 g) was purified by silica gel column chromatography (Kieselgel 60=160 g, hexane/ethyl acetate=5/1) to obtain the above-captioned compound ([9]-(94)-467) (3.0820 g) as white crystals. Melting point: 46.0-47.0 C. 1 H-NMR (500MHz, CDCl3) delta: 0.96 (t, 3H), 1.41 (t, 3H), 1.43 (sext, 2H), 1.74 (quint, 2H), 2.42 (t, 2H), 4.41 (q, 2H), 7.60 (dd, 1H), 8.04 (bs, 1H), 8.38 (dd, 1H), 8.74 (s, 1H)

The synthetic route of 13362-30-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kureha Chemical Industry Co., Ltd.; US5696118; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13362-30-6, name is Ethyl 2-aminoisonicotinate, molecular formula is C8H10N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of Ethyl 2-aminoisonicotinate

(D) Ethyl 3-[2-(4-methoxybenzyl)-2 H-1,2,3,4-tetrazol-5-yl]-4-oxo-4H-pyrido[1,2-a]-pyrimidine-8-carboxylate Ethyl 2-aminoisonicotinate (6.5 g, 39.23 mmol) was added with acetic acid (500 ml) and ethyl 3-(dimethylamino)-2-[2-(4-methoxybenzyl)-2H-1,2,3,4-tetrazol-5-yl]-2-propenoate (13 g, 39.23 mmol) and refluxed by heating at 130 C. for 5 hours. The reaction solution was returned to room temperature and poured into water, and this was extracted with chloroform. The resulting organic layer was washed with saturated brine, and the collected organic layer was dried over magnesium sulfate. The organic layer was concentrated under reduced pressure and subjected to azeotropy with toluene, and the resulting residue was purified by silica gel column chromatography (chloroform?chloroform:methanol=80:1?50:1?30:1) to obtain 8.6 g of the title compound. 1H-NMR (CDCl3) delta:1.45 (3H, t, J=7.08 Hz), 3.79 (3H, s), 4.49 (2H,q, J=7.08 Hz), 5.82 (2H, s)6.89 (2H, d, J=8.54 Hz), 7.30 (2H, d, J=8.54 Hz), 7.74 (1H, d, J=6.59 Hz), 8.39 (1H, s), 9.28 (1H, s), 9.29 (1H, d, J=6.59 Hz) EI/MS; m/z: 407 (M++1)

With the rapid development of chemical substances, we look forward to future research findings about 13362-30-6.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD; US2003/92720; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13362-30-6, name is Ethyl 2-aminoisonicotinate, molecular formula is C8H10N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of Ethyl 2-aminoisonicotinate

(D) Ethyl 3-[2-(4-methoxybenzyl)-2 H-1,2,3,4-tetrazol-5-yl]-4-oxo-4H-pyrido[1,2-a]-pyrimidine-8-carboxylate Ethyl 2-aminoisonicotinate (6.5 g, 39.23 mmol) was added with acetic acid (500 ml) and ethyl 3-(dimethylamino)-2-[2-(4-methoxybenzyl)-2H-1,2,3,4-tetrazol-5-yl]-2-propenoate (13 g, 39.23 mmol) and refluxed by heating at 130 C. for 5 hours. The reaction solution was returned to room temperature and poured into water, and this was extracted with chloroform. The resulting organic layer was washed with saturated brine, and the collected organic layer was dried over magnesium sulfate. The organic layer was concentrated under reduced pressure and subjected to azeotropy with toluene, and the resulting residue was purified by silica gel column chromatography (chloroform?chloroform:methanol=80:1?50:1?30:1) to obtain 8.6 g of the title compound. 1H-NMR (CDCl3) delta:1.45 (3H, t, J=7.08 Hz), 3.79 (3H, s), 4.49 (2H,q, J=7.08 Hz), 5.82 (2H, s)6.89 (2H, d, J=8.54 Hz), 7.30 (2H, d, J=8.54 Hz), 7.74 (1H, d, J=6.59 Hz), 8.39 (1H, s), 9.28 (1H, s), 9.29 (1H, d, J=6.59 Hz) EI/MS; m/z: 407 (M++1)

With the rapid development of chemical substances, we look forward to future research findings about 13362-30-6.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD; US2003/92720; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 13362-30-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13362-30-6, name is Ethyl 2-aminoisonicotinate. This compound has unique chemical properties. The synthetic route is as follows.

[1- [5-CHLORO-2- (4-METHOXY-BENZYLOXY)-PHENYL]-PENTANE-1,] 4-dione (1.04g, 2. [9MMOL)] and 2- amino-isonicotinic acid ethyl ester (0.54g, 3. [2MMOL)] (Linschoten et [AL,] W00066557) were heated in toluene (0. 5ml) in a sealed vessel at [150C] for 12 hours. Upon cooling, the residue was purified by chromatography on silica gel with isohexane/EtOAc (15%) as eluant, to give the title compound (510mg, 36%). [1H] NMR [(400MHZ,] CDCl3) 1.31 (3H, t, J=7.5Hz), 2.29 (3H, s), 3.79 (3H, s), 4.29 (2H, q, J=7.5Hz), 4.59 (2H, s), 6.12 (1H, d, J=3.5Hz), 6.32 (1H, d, J=3.5Hz), 6.58 (1H, broad d, J=9Hz), 6.79 (2H, d, J=8.5Hz), 6.98 (2H, d, J=8.5Hz), 7.05 (1 H, dd, J=3,9Hz), 7.26 (1 H, d, under CDCI3), 7.40 (1 H, broad s), 7.66 (1 H, dd, J=1.5, 7Hz), 8.52 (1 H, d, J=7Hz). LC/MS t=4.01 min [MH+] 477/479

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13362-30-6, Ethyl 2-aminoisonicotinate.

Reference:
Patent; GLAXO GROUP LIMITED; WO2003/101959; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 13362-30-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 13362-30-6 as follows.

To a solution of ethyl 2-aminoisonicotinate (15.45 g, 92.97 mmol) in tetrahydrofuran (300 mL) were added triethylamine (32.22 mL, 232.43 mmol), di-tert-butyl bicarbonate (50.73 g, 232.43 mmol) and 4-dimethylaminopyridine (1.14 g, 9.30 mmol), and the resulting mixture was stirred at room temperature for 15 hr. The reaction mixture was concentrated under reduced pressure, water was added to the residue, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=95/5-0/100) to give the title compound (20.35 g, yield 60%) as colorless crystals.1H NMR (CDCl3) delta 1.42 (3H, t, J=7.2 Hz), 1.45 (18H, s), 4.42 (2H, q, J=7.2 Hz), 7.77 (1H, d, J=5.1 Hz), 7.81 (1H, s), 8.61 (1H, d, J=5.1 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13362-30-6, its application will become more common.

Reference:
Patent; Itoh, Fumio; US2010/69381; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem