Category: 133627-45-9

Li, Q. Chan published the artcileValidation of a high-performance liquid chromatography method for the assay of and determination of related organic impurities in nevirapine drug substance, Application In Synthesis of 133627-45-9, the main research area is HPLC impurity determination nevirapine; liquid chromatog nevirapine impurity determination.

Nevirapine (Viramune), a dipyridiodiazepinone, is a potent and highly specific nonnucleoside inhibitor of HIV-1 reverse transcriptase. This study described the validation of a specific, sensitive, and a stability-indicating HPLC method for the determination of related organic impurities in nevirapine drug substance. This method used a Supelcosil LC-ABZ column, a mobile phase of 20:80 MeCN-pH 5.0 25-mM NH4H2PO4 and UV detection at 220 nm. This method was validated for specificity, linearity, accuracy, repeatability, detection limit, quantitation limit, stability of analyte solutions, robustness, and intermediate precision. Nevirapine was completely separated from all impurities. The method was linear with coefficients of determination >0.999. Average accuracy was 100.4% with a relative standard deviation of 0.7% for the assay. Accuracy ranges from 100.1 to 102.6% for related organic impurities. The repeatability was good, with relative standard deviations �.4%. The detection limit and the quantitation limit were 0.001 and 0.003%, resp. Relative response factors of known organic impurities were determined, permitting the use of nevirapine at the 0.1% level as an external standard for the quantitation of these impurities. Analyte solutions were stable for at least 2 days at ambient temperature The method was validated as robust, and intermediate precision was high. A system suitability test was developed and validated, and requirements were set. (c) 2000 Preston Publications.

Journal of Chromatographic Science published new progress about HPLC. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Application In Synthesis of 133627-45-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kucharska, E. published the artcileMolecular and crystal structure, IR and Raman spectra, and quantum chemical calculations for 2-hydroxy-3-cyano-4-methylpyridine, Recommanded Product: 2-Chloro-4-methylpyridin-3-amine, the main research area is hydroxycyanomethylpyridine crystallog mol structure IR Raman spectroscopy.

The paper presents the mol. and XRD structures as well as room temperature IR and Raman studies of 2-hydroxy-3-cyano-4-methylpyridine. The nature and assignment of the vibrational modes have been discussed on the basis of the quantum chem. calculations performed with the use of B3LYP/6-311G(d,p) basis set. The role of the hydrogen bonds in the stabilization of the structure has been analyzed. The quantum chem. calculations have been performed for the monomer as well as for the dimer coupled via the hydrogen bonds. A possible application of this compound in the hybrid formation technol. is discussed.

Vibrational Spectroscopy published new progress about Crystal structure. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Recommanded Product: 2-Chloro-4-methylpyridin-3-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Gang published the artcileExperimental Study on Seawater Applications in Organic Reactions, Recommanded Product: 2-Chloro-4-methylpyridin-3-amine, the main research area is organic reaction seawater application industrial production.

Background: Total water resources account for only 2.5% of freshwater on earth, and only 1% of total water resources can be exploited by humans. The development of practical methods of seawater desalination and comprehensive utilization technol. can help address the shortage of freshwater resources in the world, and achieve sustainable use of water resources to ensure sustainable development in a society. Direct seawater utilization currently involves industrial cooling water, water for agricultural irrigation, and flushing water. Applications in aqueous phase organic reactions, particularly the direct use of seawater in industrial organic synthesis reactions, are seldom reported. Methods: we used seawater instead of freshwater in selected basic organic chem. reactions. The application of seawater in aqueous phase organic reactions was systematically investigated. Six types of reactions were studied using freshwater and seawater, namely, preparation of acetanilide, synthesis of mandelic acid, Cannizzaro reaction, Hofmann degradation reaction, preparation of quinazolin-4-one, and preparation of adipic acid. Results: Seven organic compounds were produced. Results show that some organic reactions could directly use seawater or treated seawater as an alternative to freshwater. The yields of the reactions using seawater could be compared with literature values, or were even better than literature values. Conclusion: This research provides new opportunities for the comprehensive utilization of seawater. Some organic reactions could directly use seawater or treated seawater instead of freshwater. The use of seawater instead of freshwater for organic reactions in industrial production may greatly conserve freshwater resources and protect the environment.

Letters in Organic Chemistry published new progress about Cannizzaro reaction. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Recommanded Product: 2-Chloro-4-methylpyridin-3-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Empel, Anna published the artcileTowards Property Profiling: SYNTHESIS and SAR Probing of New Tetracyclic Diazaphenothiazine Analogues, Recommanded Product: 2-Chloro-4-methylpyridin-3-amine, the main research area is lung breast cancer SAR anticancer tertiary phenothiazine quinoline; antibacterial activity; antiproliferative activity; azaphenothiazines; lipophilicity; pharmacophore mapping; phenothiazine; similarity-activity landscape index.

A series of new tertiary phenothiazine derivatives containing a quinoline and a pyridine fragment was synthesized by the reaction of 1-methyl-3-benzoylthio-4-butylthioquinolinium chloride with 3-aminopyridine derivatives bearing various substituents on the pyridine ring. The direction and mechanism of the cyclization reaction of intermediates with the structure of 1-methyl-4-(3-pyridyl)aminoquinolinium-3-thiolate was related to the substituents in the 2- and 4-pyridine position. The structures of the compounds were analyzed using 1H, 13C NMR (COSY, HSQC, HMBC) and X-ray anal., resp. Moreover, the antiproliferative activity against tumor cells (A549, T47D, SNB-19) and a normal cell line (NHDF) was tested. The antibacterial screening of all the compounds was conducted against the reference and quality control strain Staphylococcus aureus ATCC 29213, three clin. isolates of methicillin-resistant S. aureus (MRSA). In silico computation of the intermol. similarity was performed using principal component anal. (PCA) and hierarchical clustering anal. (HCA) on the pool of structure/property-related descriptors calculated for the novel tetracyclic diazaphenothiazine derivatives The distance-oriented property evaluation was correlated with the exptl. anticancer activities and empirical lipophilicity as well. The quant. shape-based comparison was conducted using the CoMSA method in order to indicate the potentially valid steric, electronic and lipophilic properties. Finally, the numerical sampling of similarity-related activity landscape (SALI) provided a subtle picture of the SAR trends.

International Journal of Molecular Sciences published new progress about Antibacterial agents. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Recommanded Product: 2-Chloro-4-methylpyridin-3-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Youcan published the artcileCopper-catalyzed carbonylative synthesis of pyrrolidine-containing amides from γ,δ-unsaturated aromatic oxime esters, Related Products of pyridine-derivatives, the main research area is pyrrolidine containing amide preparation regioselective copper catalyst; unsaturated aromatic oxime ester amine carbonylative cyclization.

A new method of low-cost copper-catalyzed carbonylative cyclization for preparing pyrrolidine-containing amides I (R = H, R’ = t-Bu, Ph, 2-Py, etc; R1 = Me, Et, Ph, R2 =Me, Allyl, CHC6H5; Ar = Ph, 3-MeC6H4, 2-thiophenenyl, 2-Naph, etc.; R3, R4 = H, Me;) from γ,δ-unsaturated aromatic oxime esters II and amines has been described. A range of readily available amines were examined, including primary, secondary, and heterocycle amines, giving over 60 examples of targeted N-heterocycle substituted amides with broad functional group tolerance, good chem. selectivity and moderate to excellent yields.

Organic Chemistry Frontiers published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Related Products of pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Huiping published the artcileSynthesis of 2-cyanoacrylates containing pyridinyl moiety under ultrasound irradiation, COA of Formula: C6H7ClN2, the main research area is pyridinylaminocyanoacrylate preparation antitumor; cyanoacrylate pyridinylamino preparation antitumor; methylthiocyanoacrylate pyridinamine substitution ultrasound.

Reaction of NCCH2CO2Et with CS2 and Me2SO4 in the presence of NaOMe in anhydrous MeOH yields 2-cyano-3,3-bis(methylthio)acrylate. Further nucleophilic substitution with 3-amino-2-chloro-4-methylpyridine under ultrasonic irradiation afforded 3-[(2-chloro-4-methylpyridin-3-yl)amino]-2-cyano-3-methylthioacrylate as key intermediate. The title compounds were then obtained through the reaction of the key intermediate with primary aliphatic amines under reflux. All new structures were verified by elemental anal., IR, 1H NMR and mass spectra. In the MTT test, the compounds were found to possess moderate antitumor activities against PC3 and A431 cells.

Journal of Heterocyclic Chemistry published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, COA of Formula: C6H7ClN2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ramil, Carlo P. published the artcileSequence-Specific 2-Cyanobenzothiazole Ligation, HPLC of Formula: 133627-45-9, the main research area is cyanobenzothiazole ligation protein labeling.

The use of small, natural chem. reporters in conjunction with catalyst-free bioorthogonal reactions will greatly streamline protein labeling in a cellular environment with min. perturbation to their function. Here we report the discovery of a 2-cyanobenzothiazole (CBT)-reactive peptide tag, CX10R7, from a cysteine-encoded peptide phage library using the phage-assisted interrogation of reactivity method. Fusion of CX10R7 with a protein of interest allows site-specific labeling of the protein with CBT both in vitro and on the surface of E. coli cells. Mutagenesis studies indicated that the reactivity and specificity of CX10R7 are attributed to the sequence environment, in which the residues surrounding cysteine help to stabilize the ligation product.

Journal of the American Chemical Society published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, HPLC of Formula: 133627-45-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Dingzhong published the artcileIndustrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles-catalyzed hydrogenation of nitroarenes, Application of 2-Chloro-4-methylpyridin-3-amine, the main research area is cunninghamia lanceolata carbon support iron hydroxide oxide catalyst preparation; nitroarene iron hydroxide oxide catalyst hydrogenation; aryl amine green preparation.

An industrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles process for the synthesis of aryl amines with good yields via hydrogenation of nitroarenes was reported. Nine key anti-cancer drug intermediates were successfully achieved with protocol. And Osimertinib intermediate could be smoothly synthesized at a 2.67 kg-scale with >99.5% HPLC purity. This protocol featured cheap carbon source, highly catalytic activity, simple operation, kilogram-scalable and recyclable catalysts (eight times without observable losing activity).

Catalysis Communications published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Application of 2-Chloro-4-methylpyridin-3-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vu, Hoang Nam published the artcileSynthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists, Product Details of C6H7ClN2, the main research area is thiazolecarboxamide aryl preparation metabotropic glutamate receptor antagonist; picolinamide aryl preparation metabotropic glutamate receptor antagonist; Antagonist; Metabotropic glutamate receptor; Molecular docking; Picolinamides; Thiazole-2-carboxamides.

Herein the synthesis and biol. evaluation of picolinamides and thiazole-2-carboxamides as potential mGluR5 antagonists are described. It was found that a series of N-aryl-4-R-2-thiazolecarboxamides (R = Br, Me, CN; aryl = 3-FC6H4, 3-NCC6H4, 2-pyridyl, 6-chloro-2-pyridyl, etc.) (I) showed better inhibitory activity against mGluR5. The compounds I (R = Br; aryl = 3-BrC6H4, 6-methyl-2-pyridyl) have been identified as potent antagonists (IC50 = 274 and 159 nM) showing excellent in vitro stability profile. Mol. docking study using the crystal structure of mGluR5 revealed that these two compounds fit the allosteric binding site of mavoglurant well.

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Product Details of C6H7ClN2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rosenberg, Adam J. published the artcileSynthesis of Imidazo[4,5-b]pyridines and Imidazo[4,5-b]pyrazines by Palladium Catalyzed Amidation of 2-Chloro-3-amino-heterocycles, Application In Synthesis of 133627-45-9, the main research area is heterocyclic compound imidazopyridine imidazopyrazine preparation; pentosidine natural product model system preparation; mutagen phenylimidazopyridinamine methyl preparation; carboxylic amide coupling reaction chloropyridine chloropyrazine.

A facile synthesis of imidazo[4,5-b]pyridines and -pyrazines is described using a Pd-catalyzed amide coupling reaction. This reaction provides quick access to products with substitution at N1 and C2. A model system relevant to the natural product pentosidine (I) has been demonstrated, as well as the total synthesis of the mutagen 1-Me-5-PhIP (II).

Organic Letters published new progress about Cross-coupling reaction. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, Application In Synthesis of 133627-45-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem