Application of 134031-24-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 134031-24-6, name is 2,4-Dichloronicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.
INTERMEDIATE 11 fert-Butyl (36 -4-(2-chloro-3-formylpyridin-4-yl)-3-ethylpiperazine-l-carboxylate tert-Butyl (3i?)-3-ethylpiperazine-l-carboxylate (1.1 g, 5.1 mmol) was suspended in 1-butanol (8.1 g, 110 mmol) and DIPEA (1.3 g, 10 mmol) and 2,4-dichloropyridine-3- carbaldehyde (0.90 g, 5.1 mmol) was added. The suspension was heated at 70C for 5 h. The reaction mixture was concentrated in vacuo and the residue was purified by column chromatography, using an EtOAc/hexane gradient, to give the title compound (0.45 g, 25%) as a yellow oil. LCMS (ES+) 354 [M+H]+, RT 1.47 minutes (method 1).
According to the analysis of related databases, 134031-24-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; FORD Daniel James; REUBERSON James Thomas; US2015/376167; A1; (2015);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem