Category: 13438-65-8

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13438-65-8, name is 2-Aminonicotinamide, the common compound, a new synthetic route is introduced below. HPLC of Formula: C6H7N3O

88.1To a solution of 2-amino-nicotinamide (200 mg, 1.4 mmol) in DMF (3 ml) was added successively 1H-1,2,4-triaazole-1-acetic acid [28711-29-7] (185 mg, 1.4 mmol), diisopropylethylamine [7087-68-5] (200 mul, 1.4 mmol) and O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphatehexafluorophosphate [200731-31-3] (555 mg, 1.4 mmol) at r.t.. The reaction mixture was stirred for 18 hours. The solvent was removed in vacuo, and the residue was digested with dichloromethane to yield product as an off-white solid. Filtration and drying gave 206 mg of 2-(2-[1,2,4]triazol-1-yl-acetylamino)-nicotinamide as off-white solid, which was used without further purification in the next step.

The synthetic route of 13438-65-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Conte, Aurelia; Dehmlow, Henrietta; Grether, Uwe; Kratochwil, Nicole A.; Kuehne, Holger; Narquizian, Robert; Panousis, Constantinos; Peters, Jens-Uwe; Ricklin, Fabienne; Roever, Stephan; US2007/275987; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13438-65-8, name is 2-Aminonicotinamide. A new synthetic method of this compound is introduced below., category: pyridine-derivatives

Example 122 1-(2,5-dichlorobenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide To a solution of 2-aminonicotinamide (0.2 g) in N,N-dimethylformamide (5 ml) was added 2,5-dichlorobenzylbromide (0.39 g) (Table 2, bromide 122), and the mixture was stirred at 80C for 14 hr. The reaction mixture was diluted with ethyl acetate. The precipitate was collected by filtration and washed with ethyl acetate. The obtained precipitate was recrystallized from methanol-ethyl acetate to give the title compound (0.21 g). 1H-NMR (DMSO-d6) d ppm 5.52 (2 H, s) 6.95 (1 H, d, J=2.27 Hz) 7.06 – 7.17 (1 H, m) 7.50 – 7.59 (1 H, m) 7.63 – 7.71 (1 H, m) 8.13 (1 H, s) 8.23 (1 H, d, J=5.30 Hz) 8.52 (1 H, d, J=6.82 Hz) 8.59 (1 H, s) 9.45 (2 H, s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 13438-65-8, 2-Aminonicotinamide.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2077262; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 13438-65-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 13438-65-8 as follows.

A mixture of 2-aminonicotinamide (0.85 g, 6.20 mmol), mono-tert-butyl succinate (1.620 g, 9.30 mmol), HATU (3.54 g, 9.30 mmol) and TEA (1.728 mL, 12.40 mmol) in DMF was stirred at 60C for 20 h. The mixture was poured into water and extracted with EtOAc. The combined organic layers were washed with brine, dried and concentrated. The residual material was absorbed onto a plug of silica gel and purified by chromatography through a Redi-Sep pre-packed silica gel column (40 g), eluting with a gradient of 0% to 60% 1M NH3-MeOH in DCM, to provide tert-butyl 4- ((3-carbamoylpyridin-2-yl)amino)-4-oxobutanoate (0.70 g, 2.386 mmol, 38.5 % yield) (including -30% unidentified compound) as a light-yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13438-65-8, its application will become more common.

Reference:
Patent; AMGEN INC.; BREGMAN, Howard; BUCHANAN, John L.; CHAKKA, Nagasree; DIMAURO, Erin F.; GUNAYDIN, Hakan; GUZMAN PEREZ, Angel; HUA, Zihao; HUANG, Xin; WO2014/36022; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem