Category: 13466-38-1

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13466-38-1, name is 5-Bromopyridin-2-ol, molecular formula is C5H4BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 13466-38-1

A mixture of 5-bromopyridin-2-ol (I-99, Aldrich, Wis.; 53 g, 0.30 mol) in concentrated.H2SO4 (250 mL) was stirred with ice bath cooling and concentrated HNO3 (105 mL) was added slowly to the mixture. The reaction mixture was stirred for 4 hours at room temperature and then poured onto ice and stirred for additional 30 minutes. A yellow precipitate was filtered off used in the following step without further purification (45 g, 68%). MS (ESI): m/z 220 (M+1)+.

With the rapid development of chemical substances, we look forward to future research findings about 13466-38-1.

Reference:
Patent; Chytil, Milan; Engel, Sharon R.; Fang, Qun Kevin; Spear, Kerry L.; US2010/204214; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13466-38-1, name is 5-Bromopyridin-2-ol, molecular formula is C5H4BrNO, molecular weight is 173.9954, as common compound, the synthetic route is as follows.COA of Formula: C5H4BrNO

To a solution of N-(4-(4-hydroxy-2,6-dimethylphenyl)-thiazol-2-yl)isonicotinamide (5-3, 325 mg, 1.0 mmol) in DMF (15 mL) were added cesium carbonate (650 mg, 2.0 mmol, 2.0 equiv) and Cu (19.5 mg, 0.30 mmol, 0.30 equiv). The mixture was stirred at 80-90 C for 60 min 5-Bromo-2-hydroxypyridine (261 mg, 1.5 mmol) was added to the solutionand the reaction mixture was stirred at 100 C for additional 24 hr. The solution was quenched with water (40 mL) and extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by column chromatography on (NH silica gel, hexane/ethyl acetate = 3/1-1/3) to give 5(0.75 g) in 18% yield: 1H NMR (500 MHz, CDCl3) delta 8.31 (d, J= 5.0 Hz, 2 H), 8.29 (d, J= 5.0 Hz, 2 H), 7.23 (d, J= 9.5 Hz, 1 H), 6.81 (s, 1H), 6.60 (d, J= 4.76 Hz, 1 H), 6.49 (s, 2 H), 5.42 (s, 1 H), 2.04 (s, 6 H), ESI-MS = m/z 417.2 (M – H)-.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13466-38-1, 5-Bromopyridin-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; TAIVEX THERAPEUTICS CORPORATION; HUANG, Yu-Ling; CHUANG, Shih-Hsien; LEE, Ying-Shuan Eda; HUANG, Jiann-Jyh; LAU, Johnson; WO2013/82324; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 13466-38-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13466-38-1, name is 5-Bromopyridin-2-ol, molecular formula is C5H4BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound SM (1.73 g, 10 mol), 1-bromocyclopentane (1.79 g, 12 mmol) and cesium carbonate (6.52 g,20 mmol) was dissolved in 10 mL of DMF and reacted at 90 C overnight. The reaction is completed,Diluted with water and extracted three times with ethyl acetate. The organic phases were combined and washed three times with water.Wash once with saturated brine, dry over anhydrous sodium sulfate, and filter.The solvent was evaporated under reduced pressure, and the obtained oil was purified to give 5-bromo-1-cyclopentylpyridine-2(1H)-one (459 mg, yield 20%,White solid).

According to the analysis of related databases, 13466-38-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Liu Gang; Luo Xiaoyong; Dong Zhenwen; Li Xiaoyong; Yu Hua; Zeng Hong; Song Hongmei; Wang Ying; Wang Lichun; Wang Jingyi; (49 pag.)CN109293652; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 13466-38-1, 5-Bromopyridin-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Bromopyridin-2-ol, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Bromopyridin-2-ol

[00320] A round bottom flask was charged with 2-hydroxy-5-bromopyridine (1.0 g, 5.7 mmol) and 1,2-dimethoxy ethane (30 mL) and potassium tert-butoxide (0.65 g, 5.7 mmol) was added and the reaction mixture stirred at room temperature for 30 minutes, potassium carbonate (0.56 g, 4.0 mmol) and l-Boc-3-bromomethylazetidine (2.88 g, 11.5 mmol) were added and the reaction mixture heated to reflux overnight. The reaction mixture was cooled to room temperature and quenched with water and extracted with ethyl acetate (3X100 mL). The combined organics were washed with brine and dried over MgS04. The solvents were evaporated to dryness and the residue purified by flash chromatography (40 g silica, 0-100% ethyl acetate in hexanes) to give the product as white solid (1.65 g, 84%). LC/MS: [M+] 343.2; 1H MR (300 MHz, CDC13): delta 7.39-7.34 (m, 2H), 6.49 (d, J=9.3 Hz, IH), 4.08-3.97 (m, 4H), 3.72-3.67 (m, 2H), 3.07-3.05 (m, IH), 1.44 (s, 9H),

The synthetic route of 13466-38-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FGH BIOTECH, INC.; HUFF, Joel; UESUGI, Motonari; KINCAID, John; (213 pag.)WO2017/190086; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 13466-38-1, 5-Bromopyridin-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

Step 1 Preparation of Compound a42 (0465) Compound a41 (1.12g, 6.5mmol) was dissolved in 1,4-dioxane (15mL), t- butyl ((1S, 2R) -2- hydroxy-cyclopentyl) carbamate (1.0g 5.0mmol), triphenylphosphine (1.7g, 6.5mmol) and dimethyl oxyethyl azodicarboxylate (1.5g, 6.5mmol) were added and the mixture was stirred at 65C for 1 hour. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the ontained residue was purified by silica gel column chromatography (hexane-ethyl acetate) to give compound a42 (1.4g, 77% yield). 1H NMR (CDCl3) delta: 1.41 (s, 9H), 1.45-1.54 (m, 1H), 1.71-1.85 (m, 3H), 2.10-2.15 (m, 1H), 2.23-2.26 (m, 1H), 3.97 (m, 1H), 4.91 (m, 1H), 5.13-5.14 (m, 1H), 6.67 (d, J = 8.7 Hz, 1H), 7.63 (d, J = 8.7 Hz, 1H), 8.15 (s, 1H). [M + H] = 358.3, Method Condition 4: retention time 2.57 minutes

The synthetic route of 13466-38-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shionogi & Co., Ltd.; KOBAYASHI, Naotake; ASAHI, Kentarou; TOMIDA, Yutaka; OHDAN, Masahide; FUMOTO, Masataka; SASAKI, Yoshikazu; KURAHASHI, Kana; INOUE, Takatsugu; URABE, Tomomi; NISHIURA, Yuji; IWATSU, Masafumi; MIYAZAKI, Keisuke; OHYABU, Naoki; WADA, Toshihiro; KATOU, Manabu; (276 pag.)EP3059225; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem