Category: 13472-56-5

Adding a certain compound to certain chemical reactions, such as: 13472-56-5, 2-Methoxy-5-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H9NO, blongs to pyridine-derivatives compound. Formula: C7H9NO

n-BuLi (2.5 M, 1.95 mL) was added dropwise to a solution of 2-methoxy-5-methylpyridine (500 mg, 4.06 mmol) in THF (9 mL) at -78C and the mixture was stirred at -40C for 0.5 hours. A solution of triisopropyl borate (1.15 g, 6.09 mmol) in THF (1 mL) was added dropwise, and stirring continued for 0.5 hours at -78C.Then the reaction mixturre was stirred at 20C for an additional 12 hours. The reaction mixture was poured into water (10 mL) and stirred for 5 minutes.The aqueous phase was extracted with dichloromethane. The organic phase was washed with brine, dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel chromatography (petroleum ether/ethyl acetate) to afford the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13472-56-5, 2-Methoxy-5-methylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; LANGGARD, Morten; JESSING, Mikkel; VITAL, Paulo, Jorge, Vieira; JUHL, Karsten; MARIGO, Mauro; (142 pag.)WO2019/121840; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 13472-56-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13472-56-5, name is 2-Methoxy-5-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

2-Methoxy-5-methylpyridine (50 g, 0.4 mol) was mixed with urea peroxide (330 g, 3.5 mol) in solvent trifluoroacetic anhydride (250 mL) and reacted at 120 C for 15 h After the reaction was completed, the reaction solution was poured into crushed ice and stirred continuously. After extraction with methylene chloride, the organic phase was concentrated to give 56 g of a white solid product, i.e., the 2-methoxy-5-methylpyridine -N-oxide (yield 99%, content 97%)

According to the analysis of related databases, 13472-56-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Wuxi Jiehua Pharmaceutical Technology Co., Ltd.; Li Huan; Bao Liang; (6 pag.)CN106928130; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 13472-56-5, Adding some certain compound to certain chemical reactions, such as: 13472-56-5, name is 2-Methoxy-5-methylpyridine,molecular formula is C7H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13472-56-5.

Add 6-methoxy-3-methylpyridine and dibenzoyl peroxide to the dichloromethane solvent, turn on the stirring, reduce the temperature in the ice-water bath to 20-30 C, and add the bromine in batches to the reaction solution. , Maintain the internal temperature below 40 C, add it, heat to reflux, and react for 24 hours. The specific reaction equation is as follows:The post-treatment process is: the reaction solution is cooled to 25-30 C, filtered under reduced pressure, and the filter cake is rinsed once with dichloromethane; the filtrate is washed three times with water; concentrated under reduced pressure until no liquid drips; petroleum ether is added to the concentrated solution, The amount of petroleum ether is 3.0-4.0 times that of 6-methoxy-3-methylpyridine, beaten at 25-30 C for 30min .; filtered under reduced pressure, and the cake is dried under vacuum at 40-50 C to obtain 5- (dibromomethyl) Group) -2-methoxypyridine, yield 83.8%, purity was measured by HPLC method, and purity was 99%.Among them, the amount of methylene chloride is 4.0-5.0 times that of 6-methoxy-3-methylpyridineThe molar ratio of 6-methoxy-3-methylpyridine to the catalyst was 1: 0.01.The molar ratio of 6-methoxy-3-methylpyridine to bromine is 1: 2.6.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13472-56-5, 2-Methoxy-5-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing Habo Pharmaceutical Technology Co., Ltd.; Zhao Xiaolin; Cui Jiayi; Wang Jinzhu; Zhao Bing; Ai Yangbao; (10 pag.)CN110878043; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem