Synthetic Route of 13472-61-2, Adding some certain compound to certain chemical reactions, such as: 13472-61-2, name is 5-Iodo-2-methoxypyridine,molecular formula is C6H6INO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13472-61-2.
To a 25-mL flask equipped with a magnetic stir bar and a condenser crowned with argon balloon, charged with a mixture of anhydrous DMF (4 mL) and 5-iodo-2-methoxypyridine (0.99 g, 0.042 mmol), degassed for 2 h using a stream of argon slowly bubbled through the solution at rt. during vigorous stirring, phenylacetylene (0.055 mmol), Pd(PPh3)2Cl2 (38 mg), CuI (8 mg) were added. Subsequently anhydrous Et3N (1.5 mL) was added over 10 minutes and the mixture was heated at 50 C for 90 minutes. After this time the reaction mixture was cooled to rt. and aqueous saturated NaCl (10 mL) was added, the mixture was extracted with ethyl acetate (3 x 50 mL) and the combined organic layers were washed with brine (5 mL), dried over MgSO4 and filtered through the pad of Celite. Concentration in vacuo and purification by flash column chromatography (silica gel, n-hexane : ethyl acetate 9 : 1) yielded 1d in 90% yield as colourless oil.
According to the analysis of related databases, 13472-61-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Sos?nicki, Jacek G.; Struk, ?ukasz; Idzik, Tomasz; Maciejewska, Gabriela; Tetrahedron; vol. 70; 45; (2014); p. 8624 – 8635;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem