Category: 13472-84-9

Chai, Huifang; Zeng, Xiaoping; Teng, Minggang; Duan, Lian published the artcile< Synthesis of 2, 3-dichloro-5-iodopyridine>, Quality Control of 13472-84-9, the main research area is dichloro iodopyridine synthesis.

In the paper, we introduced a approach to synthesize the title compound, was realized and manufactured from 2, 3-dichloropyridine via four steps. Its structure was verified by MS and 1H NMR. This synthetic route has the advantages of convenient operation and mild reaction conditions. The total product yield was 51%. This program is suitable for industrial production

Guangdong Huagong published new progress about Chlorination. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Quality Control of 13472-84-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13472-84-9, name is 3-Chloro-2-methoxypyridine. A new synthetic method of this compound is introduced below., Recommanded Product: 3-Chloro-2-methoxypyridine

General procedure: An oven-dried reaction flask, equipped with a reflux condenser was charged with heteroaryl chloride (1.0 mmol), 4-(N-Boc-N-methyl)aminopiperidine (1.3 equiv.), Pd(OAc)2 (3 mol%), DavePhos (3 mol%), t-BuONa (1.2 equiv.). The flask was sealed, and was evacuated and backfilled with argon for three times. Then 3 mL toluene was added to the system with a syringe. The reaction mixture was stirred at 120 C for 12 h. After cooling to the room temperature, the resulting residue was filtered through a plug of silica gel and washed with ethyl acetate. The mixture was then poured into water and extracted. The combined organic layers were washed with brine, dried over MgSO4, and filtered. The solvent was removed under vacuum. The residue was purified by flash column chromatography to afford the desired product.

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Reference:
Article; Zhang, Kena; Li, Hui; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng; Tetrahedron Letters; vol. 58; 20; (2017); p. 1976 – 1979;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem