Category: 13509-13-2

Related Products of 13509-13-2, Adding some certain compound to certain chemical reactions, such as: 13509-13-2, name is Methyl 4-methylpicolinate,molecular formula is C8H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13509-13-2.

1-(3-Benzyl-5-pyrazin-2-yl-phenyl)-3-(4-methyl-pyridin-2-yl)-propane-1,3-dione (25B). In an oven dried flask equipped with a rubber septum with bubbling argon was dissolved 25A (0.15 g, 0.00052 mole) and 3H (0.078 g, 0.00052 mole) in 1 mL of anhydrous THF. NaOMe (56 mg, 0.00104 mole) was added and the reaction turned a brown color. After 0.5 hour the reaction was poured into 8 mL of a saturated NH4Cl solution. The mixture was extracted 3 times with EtOAc, dried NaSO4, filtered and evaporated to give a crude product. The oily solids were crystallized with and hot petroleum ether in a sonicator. Solids were collected by vacuum filtration to give pure light yellow powder, (25B). 1H NMR (400 MHz, CDCl3) delta 9.05 (s, 1H), 8.65 (s, 1H), 8.58 (d, j=5.0 Hz, 1H), 8.4 (m, 2H), 8.04 (s, 2H), 8.02 (s, 1H), 7.62 (s, 1H), 7.33-7.21 (m, 6H), 4.17 (s, 2H), 2.47 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13509-13-2, Methyl 4-methylpicolinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Payne, Linda S.; Tran, Lekhanh O.; Zhuang, Linghang H.; Young, Steven D.; Egbertson, Melissa S.; Wai, John S.; Embrey, Mark W.; Fisher, Thorsten E.; Guare, James P.; Langford, H. Marie; Melamed, Jeffrey Y.; Clark, David L.; US2003/229079; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 13509-13-2, Adding some certain compound to certain chemical reactions, such as: 13509-13-2, name is Methyl 4-methylpicolinate,molecular formula is C8H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13509-13-2.

Step 4. The preparation of 4-methyl-1-(3-methyl-butyl)-piperidine-2-carboxylic acid methyl ester: 4-Methyl-pyridine-2-carboxylic acid methyl ester (1.17 g, 7.74 mmol) was dissolved in acetic acid (50 mL), treated with PtO2 (0.5 g), and shaken under an atmosphere of H2 (50 psi) for thirty hours. The reaction mixture was evaporated under reduced pressure, then redissolved in EtOH (50 mL), treated with isovaleraldehyde (0.5 mL, 15 mmol) and 20% Pd/C (0.2 g), and shaken under H2 (50 psi) for twenty hours. The reaction was filtered and concentrated in vacuo. The residue was chromatographed on silica gel eluding with 10% MeOH/CH2Cl2 to give 1.36 g (77%) of the desired product. MS: 228 (M+1 for C13H15N1O2).

According to the analysis of related databases, 13509-13-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Warner-Lambert; US6251919; (2001); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem