Category: 13534-97-9

In 2015,Gupta, G.; Iqbal, P.; Yin, F.; Liu, J.; Palmer, R. E.; Sharma, S.; Leung, K. Cham-Fai; Mendes, P. M. published 《Pt Diffusion Dynamics for the Formation Cr-Pt Core-Shell Nanoparticles》.Langmuir published the findings.HPLC of Formula: 13534-97-9 The information in the text is summarized as follows:

Layered core-shell bimetallic Cr-Pt nanoparticles were prepared by the formation and later reduction of an intermediate Pt-ion-containing supramol. complex onto preformed Cr nanoparticles. The resultant nanoparticles were characterized by x-ray diffraction anal., TEM, XPS, and aberration-corrected scanning TEM. The results are consistent with the presence of Pt diffusion during or after bimetallic nanoparticle formation, which resulted in a Pt/Cr-alloyed core and shell. The authors postulate that such Pt diffusion occurs by an elec.-field-assisted process according to Cabrera-Mott theory and that it originates from the low work function of the preformed oxygen-defective Cr nanoparticles and the rather large electron affinity of Pt. The experimental process involved the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9HPLC of Formula: 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).HPLC of Formula: 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Gao, Jie; Bhunia, Subhajit; Wang, Kailiang; Gan, Lu; Xia, Shanghua; Ma, Dawei published 《Discovery of N-(Naphthalen-1-yl)-N’-alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination with High Turnovers》.Organic Letters published the findings.Product Details of 13534-97-9 The information in the text is summarized as follows:

In the presence of Cu2O and the oxalamide I, aryl- and heteroaryl bromides and iodides were aminated chemoselectively with primary amines (alkyl favored over aryl), ammonium hydroxide, and secondary cyclic amines and N-methylbenzylamine using KOH in EtOH at 50-80° to yield aryl- and heteroarylamines such as N-benzyl-p-anisidine in 35-98% yields using 0.1-0.5 mol% of Cu2O. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9Product Details of 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Product Details of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H5BrN2In 2014 ,《Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, as new anti-malarial agents》 was published in Molecules. The article was written by Houze, Sandrine; Hoang, Nha-Thu; Lozach, Olivier; Le Bras, Jacques; Meijer, Laurent; Galons, Herve; Demange, Luc. The article contains the following contents:

In Africa, malaria kills one child each minute. It is also responsible for about one million deaths worldwide each year. Plasmodium falciparum, is the protozoan responsible for the most lethal form of the disease, with resistance developing against the available anti-malarial drugs. Among newly proposed anti-malaria targets, are the P. falciparum cyclin-dependent kinases (PfCDKs). There are involved in different stages of the protozoan growth and development but share high sequence homol. with human cyclin-dependent kinases (CDKs). We previously reported the synthesis of CDKs inhibitors that are structurally-related to (R)-roscovitine, a 2,6,9-trisubstituted purine, and they showed activity against neuronal diseases and cancers. In this report, we describe the synthesis and the characterization of new CDK inhibitors, active in reducing the in vitro growth of P. falciparum (3D7 and 7G8 strains). Six compounds are more potent inhibitors than roscovitine, and three exhibited IC50 values close to 1 μM for both 3D7 and 7G8 strains. Although, such mols. do inhibit P. falciparum growth, they require further studies to improve their selectivity for PfCDKs. In addition to this study using 6-Bromopyridin-3-amine, there are many other studies that have used 6-Bromopyridin-3-amine(cas: 13534-97-9COA of Formula: C5H5BrN2) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.COA of Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kunfi, Attila; Jablonkai, Istvan; Gazdag, Tamas; Mayer, Peter J.; Kalapos, Peter Pal; Nemeth, Krisztina; Holczbauer, Tamas; London, Gabor published their research in RSC Advances in 2021. The article was titled 《A photoresponsive palladium complex of an azopyridyl-triazole ligand: light-controlled solubility drives catalytic activity in the Suzuki coupling reaction》.Product Details of 13534-97-9 The article contains the following contents:

Herein, the design and synthesis of a click-derived Pd-complex merged with a photoswitchable azobenzene unit is presented. While in the trans-form of the switch the complex showed limited solubility, the photogenerated cis-form rendered the mol. soluble in polar solvents. This light-controllable solubility was exploited to affect the catalytic activity in the Suzuki coupling reaction. The effect of the substrate and catalyst concentration and light intensity on the proceeding and outcome of the reaction was studied. Dehalogenation of the aryl iodide starting material was found to be a major side reaction; however, its occurrence was dependent on the applied light intensity. The experimental process involved the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Product Details of 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Product Details of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 6-Bromopyridin-3-amineIn 2010 ,《Synthesis of 2,2′-bipyridines via Suzuki-Miyaura cross-coupling》 appeared in Synthesis. The author of the article were Guetz, Christoph; Luetzen, Arne. The article conveys some information:

For a long time, the Suzuki-Miyaura cross-coupling reaction could not be used for the synthesis of 2,2′-bipyridines due to the lack of sufficiently stable 2-pyridylboron compounds Stabilized 2-pyridylboronates, recently developed by Hodgson, however, were ideally suited for this purpose. Two general protocols could be developed and demonstrated to be valuable alternatives, which can be used very efficiently for the synthesis of functionalized 2,2′-bipyridines. After reading the article, we found that the author used 6-Bromopyridin-3-amine(cas: 13534-97-9Quality Control of 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Quality Control of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2012,Reis, Lindomar A.; Ligiero, Carolina B. P.; Andrade, Acacio A.; Taylor, Jason G.; Miranda, Paulo C. M. L. published 《Preparation of polyaminopyridines using a CuI/-proline-catalyzed C-N polycoupling reaction》.Materials published the findings.Product Details of 13534-97-9 The information in the text is summarized as follows:

Polyaminopyridines (PAPy) were chem. prepared from amino-bromopyridines by a CuI/-proline-catalyzed C-N polycondensation reaction. The formation of the polymer was confirmed by GPC, x-ray diffraction, XRF, FTIR, UV-vis (λmax = 400 nm), 1H and 13C NMR. The number-average mol. weights (Mn) were estimated by end-group anal. using x-ray fluorescence (up to 6000 Da). TGA anal. of PAPy with higher Mn showed greater thermal stability up to 170 °C. Viscosity measurements of polymer in formic acid at 30 °C indicated a polyelectrolyte nature of PAPy solutions Furthermore, the amorphicity of the material was observed by x-ray diffraction anal. In addition to this study using 6-Bromopyridin-3-amine, there are many other studies that have used 6-Bromopyridin-3-amine(cas: 13534-97-9Product Details of 13534-97-9) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Product Details of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2012,Salvi, Luca; Davis, Nicole R.; Ali, Siraj Z.; Buchwald, Stephen L. published 《A New Biarylphosphine Ligand for the Pd-Catalyzed Synthesis of Diaryl Ethers under Mild Conditions》.Organic Letters published the findings.HPLC of Formula: 13534-97-9 The information in the text is summarized as follows:

A new bulky biarylphosphine ligand has been developed that allows the Pd-catalyzed C-O cross-coupling of a wide range of aryl halides and phenols under milder conditions. The experimental process involved the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9HPLC of Formula: 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.HPLC of Formula: 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 6-Bromopyridin-3-amineIn 2018 ,《Synergistic effects in Fe nanoparticles doped with ppm levels of (Pd + Ni). A new catalyst for sustainable nitro group reductionsã€?was published in Green Chemistry. The article was written by Pang, Haobo; Gallou, Fabrice; Sohn, Hyuntae; Camacho-Bunquin, Jeffrey; Delferro, Massimiliano; Lipshutz, Bruce H.. The article contains the following contents:

A remarkable synergistic effect was uncovered between ppm levels of Pd and Ni embedded within Fe nanoparticles that leads to mild and selective catalytic reductions of nitroarenes in water using TPGS-750-M as surfactant at room temperature NaBH4 serves as an inexpensive source of hydride. Broad substrate scope is documented, along with several other features including: low catalyst loading, low residual metal in the products, and recycling of the catalyst and reaction medium, highlight the green nature of this new technol. In addition to this study using 6-Bromopyridin-3-amine, there are many other studies that have used 6-Bromopyridin-3-amine(cas: 13534-97-9Reference of 6-Bromopyridin-3-amine) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Reference of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zwergel, Clemens; Di Bello, Elisabetta; Fioravanti, Rossella; Conte, Mariarosaria; Nebbioso, Angela; Mazzone, Roberta; Brosch, Gerald; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Valente, Sergio; Mai, Antonello published their research in ChemMedChem in 2021. The article was titled 《Novel Pyridine-Based Hydroxamates and 2-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activityã€?Reference of 6-Bromopyridin-3-amine The article contains the following contents:

Starting from the N-hydroxy-3-((4-(2-phenylbutanoyl)amino)phenyl)acrylamide (5 b) previously described by us as a HDAC inhibitor, we prepared four aza-analogs, 6-8, 9 b, as regioisomers containing the pyridine nucleus. Preliminary screening against mHDAC1 highlighted the N-hydroxy-5-((2-(2-phenylbutanoyl)amino)pyridyl)acrylamide (9 b) as the most potent inhibitor. Thus, we further developed both pyridylacrylic- and nicotinic-based hydroxamates (9 a, 9 c-f, and 11 a-f) and 2-aminoanilides (10 a-f and 12 a-f), related to 9 b, to be tested against HDACs. Among them, the nicotinic hydroxamate 11 d displayed sub-nanomolar potency (IC50: 0.5 nM) and selectivity up to 34 000 times that of HDAC4 and from 100 to 1300 times that of all the other tested HDAC isoforms. The 2-aminoanilides were class I-selective HDAC inhibitors, generally more potent against HDAC3, with the nicotinic anilide 12 d being the most effective (IC50HDAC3=0.113μM). When tested in U937 leukemia cells, the hydroxamates 9 e, 11 c, and 11 d blocked over 80% of cells in G2/M phase, whereas the anilides did not alter cell-cycle progress. In the same cell line, the hydroxamate 11 c and the anilide 10 b induced about 30% apoptosis, and the anilide 12 c displayed about 40% cytodifferentiation. Finally, the most potent compounds in leukemia cells 9 b, 11 c, 10 b, 10 e, and 12 c were also tested in K562, HCT116, and A549 cancer cells, displaying antiproliferative IC50 values at single-digit to sub-micromolar level.6-Bromopyridin-3-amine(cas: 13534-97-9Reference of 6-Bromopyridin-3-amine) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Reference of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nemeth, Andras Gy.; Szabo, Renata; Orsy, Gyorgy; Mandity, Istvan M.; Keseru, Gyorgy M.; Abranyi-Balogh, Peter published an article in 2021. The article was titled 《Continuous-flow synthesis of thioureas, enabled by aqueous polysulfide solutionã€? and you may find the article in Molecules.Synthetic Route of C5H5BrN2 The information in the text is summarized as follows:

The continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur was developed. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur. In the experiment, the researchers used many compounds, for example, 6-Bromopyridin-3-amine(cas: 13534-97-9Synthetic Route of C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHRâ€? to form imines (R2C=NRâ€?. Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Synthetic Route of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem