Category: 13575-41-2

Adding a certain compound to certain chemical reactions, such as: 13575-41-2, Thiazolo[4,5-b]pyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H5N3S, blongs to pyridine-derivatives compound. COA of Formula: C6H5N3S

To a solution of Example 1.54.2 (60 mg) in dichloromethane (4 mL) was added thiazolo[4,5-b]pyridin-2-amine (7.56 mg), 1-ethyl-3-[3-(dimethylamino)propyl]-carbodiimide hydrochloride (19 mg) and 4-(dimethylamino)pyridine (12.2 mg), and the mixture was stirred overnight. The reaction mixture was diluted with ethyl acetate (200 mL), washed with water and brine, and dried over sodium sulfate. Filtration and evaporation of the solvent gave the title product, which was dissolved in dichloromethane/trifluoroacetic acid (1:1, 6 mL) and stirred overnight. After evaporation of solvent, the residue was dissolved in N,N-dimethylformamide/water (1:1, 12 mL) and purified by reverse phase HPLC (Gilson system), eluting with 10-85% acetonitrile in water containing 0.1% trifluoroacetic acid, to give the title compound. 1H NMR (400 MHz, dimethyl sulfoxide-d6) delta ppm 13.42 (s, 1H), 9.05 (s, 1H), 8.51-8.69 (m, 2H), 8.31-8.41 (m, 2H), 8.18-8.26 (m, 4H), 8.06 (d, 1H), 7.97 (d, 1H), 7.68-7.79 (m, 1H), 7.49 (s, 1H), 7.40 (dd, 1H), 3.90 (s, 3H), 3.18-3.29 (m, 3H), 3.07-3.15 (m, 2H), 2.82 (t, 3H), 2.24 (s, 3H), 1.44 (s, 2H), 0.97-1.37 (m, 10H), 0.88 (s, 6H). MS (ESI) m/e 850.1 (M+H)+.

The synthetic route of 13575-41-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AbbVie Inc.; Benatuil, Lorenzo; Bruncko, Milan; Chao, Debra; Izeradjene, Kamel; Judd, Andrew S.; Phillips, Andrew C.; Souers, Andrew J.; Thakur, Archana; (556 pag.)US2017/355769; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 13575-41-2, Thiazolo[4,5-b]pyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 13575-41-2, blongs to pyridine-derivatives compound. Quality Control of Thiazolo[4,5-b]pyridin-2-amine

(4) 15.7 g of isoamyl nitrite was added dropwise to a solution of 8.1 g of compound 4 in 160 ml of dry tetrahydrofuran(20min), and then heated to 65 degrees reflux 4h; TLC detection reaction should be terminated, down to room temperature, filter out nothing,Filter cake ethyl acetate (50 mL * 3), spin dry system, purified by column (200-300 mesh silica gel column) petroleum ether:Ethyl acetate = 1: 1),(Product 5) was obtained in a yield of 46.6%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13575-41-2, its application will become more common.

Reference:
Patent; Sphinx Scientific Laboratory (Tianjin) Co., Ltd.; Yao, Qingjia; Xu, Yangjun; Wu, Simin; (6 pag.)CN104402910; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem