Category: 1357947-08-0

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1357947-08-0, name is 5-Bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine, the common compound, a new synthetic route is introduced below. Safety of 5-Bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine

To a microwave tube was added 5-bromo-3-iodo-lH-pyrazolo[3,4-c]pyridine (100 mg, 0.31 mmol), pyridin-3-ylboronic acid (343 mg, 2.79 mmol), Pd(dppf)Cl2 (24 mg, 0.03 mmol), sodium carbonate (131 mg, 1.24 mmol), 1 ,2-dimethoxyethane (2 mL), ethanol (0.5 mL) and water (0.5 mL). The tube was flushed with nitrogen for 2 minutes and heated in a Biotage microwave at 160 C for 1 hour. The solvent was distilled off and the crude product was purified via reverse phase HPLC eluting with 15%> CH3CN in aqueous 10 mmol NH4HC03 to afford 176 as a pale yellow solid (30 mg, 28%). 1H NMR (500 MHz, DMSO) 1H NMR (500 MHz, DMSO) delta 14.1 (s, 1H), 9.44 (s, 1H), 9.37 (s, 3H), 9.26 (s, 1H), 8.71 (s, 1H), 8.67 – 8.66 (m, 1H), 8.60 – 8.59 (m, 2H), 8.56 -8.54 (m, 1H), 7.60 – 7.58 (m, 1H), 7.52 – 7.51 (m, 1H). ESI MS m/z = 274 (M+l)

The synthetic route of 1357947-08-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; DO, Steven; HU, Huiyong; KOLESNIKOV, Aleksandr; LEE, Wendy; TSUI, Vickie Hsiao-Wei; WANG, Xiaojing; WEN, Zhaoyang; WO2013/24002; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1357947-08-0, name is 5-Bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine, the common compound, a new synthetic route is introduced below. Safety of 5-Bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine

To a microwave tube was added 5-bromo-3-iodo-lH-pyrazolo[3,4-c]pyridine (100 mg, 0.31 mmol), pyridin-3-ylboronic acid (343 mg, 2.79 mmol), Pd(dppf)Cl2 (24 mg, 0.03 mmol), sodium carbonate (131 mg, 1.24 mmol), 1 ,2-dimethoxyethane (2 mL), ethanol (0.5 mL) and water (0.5 mL). The tube was flushed with nitrogen for 2 minutes and heated in a Biotage microwave at 160 C for 1 hour. The solvent was distilled off and the crude product was purified via reverse phase HPLC eluting with 15%> CH3CN in aqueous 10 mmol NH4HC03 to afford 176 as a pale yellow solid (30 mg, 28%). 1H NMR (500 MHz, DMSO) 1H NMR (500 MHz, DMSO) delta 14.1 (s, 1H), 9.44 (s, 1H), 9.37 (s, 3H), 9.26 (s, 1H), 8.71 (s, 1H), 8.67 – 8.66 (m, 1H), 8.60 – 8.59 (m, 2H), 8.56 -8.54 (m, 1H), 7.60 – 7.58 (m, 1H), 7.52 – 7.51 (m, 1H). ESI MS m/z = 274 (M+l)

The synthetic route of 1357947-08-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; DO, Steven; HU, Huiyong; KOLESNIKOV, Aleksandr; LEE, Wendy; TSUI, Vickie Hsiao-Wei; WANG, Xiaojing; WEN, Zhaoyang; WO2013/24002; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1357947-08-0, 5-Bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H3BrIN3, blongs to pyridine-derivatives compound. Formula: C6H3BrIN3

The product from Step a (1.18 g, 3.65 mmol) was combined with doubly SEM-protected 1 ,3-dihydro-5-(4,4,5,5-tetramethyl- 1 ,3,2-dioxaborolan-2-yl)-2//-bendimidazol-2- one (1.9 g, 3.65 mmol), and Pd(dppf)Ch (267 mg, 0.365 mmol) in dioxane (36.5 ml). A solution of 1 M aqueous Na2C03 (11.0 ml) was added, and the solution was sparged with nitrogen for one minute. The reaction was sealed and heated to 1 10 C for 15 hours, at which point the reaction was concentrated onto Celite and purified by flash chromatography over silica gel (ethyl acetate/hexanes 0% to 40%). Yield: 247 mg, (12%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1357947-08-0, 5-Bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; ARCUS BIOSCIENCES, INC.; BEATTY, Joel; DEBIEN, Laurent Pierre Paul; DREW, Samuel Lawrie; FOURNIER, Jeremy; GRANGE, Rebecca Louise; JACOB, Steven Donald; JEFFREY, Jenna Leigh; LAWSON, Kenneth V.; LELETI, Manmohan Reddy; LINDSEY, Erick Allen; MANDAL, Debashis; POWERS, Jay Patrick; TRAN, Anh Thu; THOMAS-TRAN, Rhiannon; YAN, Xuelei; (164 pag.)WO2020/46813; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1357947-08-0, name is 5-Bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine, molecular formula is C6H3BrIN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C6H3BrIN3

To a solution of 5-bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine (1 equiv) in CH3CN (10 vol) was added tert-butyl 2-bromoacetate (1.1 equiv) and potassium carbonate (1.1 equiv). The mixturewas refluxed overnight under an atmosphere of argon. After cooling the reaction mixture to room temperature, the mixture was filtered through Celite and washed with CH3CN. The filtrate was concentrated under reduced pressure and the remaining residue was purified by column chromatography on silica gel (eluted with DCMIMeOH) to afford compound 104-S2.

With the rapid development of chemical substances, we look forward to future research findings about 1357947-08-0.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; BARRISH, Joel, Charles; GREENLEE, William; EASTMAN, Kyle, J.; (0 pag.)WO2018/160889; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem