Category: 13602-11-4

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13602-11-4, name is Methyl 6-methylpyridine-2-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 13602-11-4

Step 3 in N2 condition, compound 3 (10g, 66.2mmol), CCl4(100 ml), NBS is sequentially added in the solution (17.7g, 99 . 3mmol), AIBN (543.5 mg, 3 . 3mmol), reflux reaction 12h, after detecting reaction is complete, concentrated under reduced pressure, by adding water, extraction with ethyl acetate, combined with the phase, ethyl acetate is removed under reduced pressure, the oily compound crocatus obtained. Recrystallization with petroleum ether and ethyl acetate (10:1) finally obtaining the white solid compound 4 (7.8g), yield 51.3%. This step attempts to adopt different post-processing method, of column chromatography, recrystallization effect is not good, and recrystallization to obtain product is a white solid, no other color.

With the rapid development of chemical substances, we look forward to future research findings about 13602-11-4.

Reference:
Patent; Shanghai Institute Of Technology; Yao, Zhiyi; Zhang, Xiaopan; Zong, Haoqiang; Wang, Dongsheng; (14 pag.)CN105294552; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13602-11-4, name is Methyl 6-methylpyridine-2-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 13602-11-4

Step 3 in N2 condition, compound 3 (10g, 66.2mmol), CCl4(100 ml), NBS is sequentially added in the solution (17.7g, 99 . 3mmol), AIBN (543.5 mg, 3 . 3mmol), reflux reaction 12h, after detecting reaction is complete, concentrated under reduced pressure, by adding water, extraction with ethyl acetate, combined with the phase, ethyl acetate is removed under reduced pressure, the oily compound crocatus obtained. Recrystallization with petroleum ether and ethyl acetate (10:1) finally obtaining the white solid compound 4 (7.8g), yield 51.3%. This step attempts to adopt different post-processing method, of column chromatography, recrystallization effect is not good, and recrystallization to obtain product is a white solid, no other color.

With the rapid development of chemical substances, we look forward to future research findings about 13602-11-4.

Reference:
Patent; Shanghai Institute Of Technology; Yao, Zhiyi; Zhang, Xiaopan; Zong, Haoqiang; Wang, Dongsheng; (14 pag.)CN105294552; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 13602-11-4 ,Some common heterocyclic compound, 13602-11-4, molecular formula is C8H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

INTERMEDIATE 88- PREPARATION of methyl 6-(bromomethyl)picolinate. A mixture of methyl 6-methylpicolinate (1.81 g; 1 1.97 mmol) and carbon tetrachloride (60 ml_) was treated with /V-bromosuccinimide (2.37 g, 13.17 mmol) and benzoyl peroxide (0.299 g; 1.20 mmol) and heated at refluxing temperature for 21 hours. The resulting brown suspension was concentrated under reduced pressure and the residue purified by flash chromatography on silica gel (eluent 0 to 6% ethyl acetate in dichloromethane) to give 0.773 g (28%) of methyl 6-(bromomethyl)picolinate as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13602-11-4, its application will become more common.

Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D; REMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; ALLASIA, Sara; MARCHAND, Arnaud; KILONDA, Amuri; CHALTIN, Patrick; WO2012/80221; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem