With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.136117-70-9, name is Imidazo[1,2-a]pyridine-8-carbonitrile, molecular formula is C8H5N3, molecular weight is 143.1454, as common compound, the synthetic route is as follows.Product Details of 136117-70-9
Synthesis of 3-iodoimidazo [1 ,2-a]pyridine-8 -carbonitrile. To a stuffed solution of imidazo[1,2-a]pyridine-8-carbonitrile (1.2 g, 8.38 mmol) in dichloromethane (10 mL) was added N-iodosuccinimide (1.89 g, 8.38 mmol). LCMS monitored the reaction until the starting material consumed completely. The reaction mixture was dilutedwith dichloromethane and water. The separated organic layer was dried sodium sulfate, filtered and concentrated to give 3-iodoimidazo[1,2-a]pyridine-8-carbonitrile (1.8 g, 6.69 mmol, 80 % yield) as a brown solid. MS (ES+) C8H81N3 requires: 269, found: 270 [M + H].
At the same time, in my other blogs, there are other synthetic methods of this type of compound,136117-70-9, Imidazo[1,2-a]pyridine-8-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.; WO2014/11900; (2014); A2;,
Pyridine – Wikipedia,
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