Category: 136818-50-3

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 136818-50-3, name is 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, the common compound, a new synthetic route is introduced below. Product Details of 136818-50-3

To the stirred solution of lH-pyrrolo[2,3-b]pyridine-2-carboxylic acid (5, 2.5 g, 15.4 mmol) and Nu,Omicron-dimethylhydroxylamine hydrochloride (6, 1.8 g, 18.5 mmol in DCM (50 mL), was added triethylamine (10.6 mL, 77.1 mmol), HOBt (3.54 g, 23.14 mmol) followed by EDC.HC1 (4.42 g, 23.18 mmol) at 0C and the reaction mixture was stirred at room temperature for 16h. The reaction mixture was cooled to room temperature, filtered through celite and evaporated the filtrate. To the crude, added water (10 mL) and compound was extracted with DCM (30mL). Organic layer was dried over sodium sulfate and evaporated to get crude product. The crude residue was purified by gradient column chromatography using silica gel and eluent 2-4% MeOH in DCM to afford the product as off white solid. (Yield: 82%, 2.6 g). MS (ESI): mass calcd. for CioHnN302, 205.09; m/z found, 206.1 (M+H)+.

The synthetic route of 136818-50-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JUBILANT BIOSYS LIMITED; HALLUR, Gurulingappa; DURAISWAMY, Athisayamani Jeyaraj; PURRA, Buchi Reddy; RAO, N.V.S.K.; RAJAGOPAL, Sridharan; (247 pag.)WO2019/58393; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 136818-50-3, name is 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, the common compound, a new synthetic route is introduced below. name: 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid

To the stirred solution of lH-pyrrolo[2,3-b]pyridine-2-carboxylic acid (5, 2.5 g, 15.4 mmol) and Nu,Omicron-dimethylhydroxylamine hydrochloride (6, 1.8 g, 18.5 mmol in DCM (50 mL), was added triethylamine (10.6 mL, 77.1 mmol), HOBt (3.54 g, 23.14 mmol) followed by EDC.HC1 (4.42 g, 23.18 mmol) at 0C and the reaction mixture was stirred at room temperature for 16h. The reaction mixture was cooled to room temperature, filtered through celite and evaporated the filtrate. To the crude, added water (10 mL) and compound was extracted with DCM (30mL). Organic layer was dried over sodium sulfate and evaporated to get crude product. The crude residue was purified by gradient column chromatography using silica gel and eluent 2-4% MeOH in DCM to afford the product as off white solid. (Yield: 82%, 2.6 g). MS (ESI): mass calcd. for CioHnN302, 205.09; m/z found, 206.1 (M+H)+.

The synthetic route of 136818-50-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JUBILANT BIOSYS LIMITED; HALLUR, Gurulingappa; DURAISWAMY, Athisayamani Jeyaraj; PURRA, Buchi Reddy; RAO, N.V.S.K.; RAJAGOPAL, Sridharan; (247 pag.)WO2019/58393; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 136818-50-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 136818-50-3, name is 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, molecular formula is C8H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 13Synthesis of3- ( (dimethylamino) methyl) -lH-pyrrolo [2, 3-£>]pyridine-2- carboxylic acid19Treatment of 2 with a mixture of dimethylamine and aqueous formaldehyde gives3- ( (dimethylamino) methyl) -lH-pyrrolo [2 , 3-£>]pyridine-2-carboxyl ic acid (19) by Mannich reaction.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 136818-50-3, 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid.

Reference:
Patent; IRONWOOD PHARMACEUTICALS INCORPORATED; LUDRIGAN, Regina; JEFFREY, John; MERMERIAN, Ara; WO2010/5528; (2010); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 136818-50-3, 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

Synthesis of 3-bromo-lH-pyrrolo [2 , 3-jb]pyridine-2-carboxylic acid and methyl 3-bromo-lif-pyrrolo [2 , 3-?>]pyridine-2-carboxylate2 4 Treatment of 2 with i7-bromosuccinimide in chloroform gives3-bromo-lH-pyrrolo [2 , 3-jb]pyridine-2-carboxylic acid (4) .

The synthetic route of 136818-50-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IRONWOOD PHARMACEUTICALS INCORPORATED; LUDRIGAN, Regina; JEFFREY, John; MERMERIAN, Ara; WO2010/5528; (2010); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem