Category: 137178-88-2

Electric Literature of 137178-88-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 137178-88-2, name is 5-Bromopyridine-2-carbonyl chloride. This compound has unique chemical properties. The synthetic route is as follows.

Step 2: (0567) After addition of THF (200 mL) and Et3N (42 mL) to the above residue, the mixture was cooled in an ice-water bath. Benzyl alcohol (31.1 mL, 300 mmol) was added slowly. The mixture was warmed up to room temperature and stirred overnight. (0568) The reaction mixture was diluted with ether, washed with sat. NaHCO3(aq.), H2O, brine and then dried (MgSO4). After concentration and crystallization, the desired product benzyl 5-bromopicolinate (20.6 g) was obtained.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 137178-88-2, 5-Bromopyridine-2-carbonyl chloride.

Reference:
Patent; MERCK SHARP & DOHME CORP.; Scott, Jack D.; Stamford, Andrew W.; Gilbert, Eric J.; Cumming, Jared N.; Iserloh, Ulrich; Misiaszek, Jeffrey A.; Li, Guoqing; US2015/307465; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 137178-88-2, Adding some certain compound to certain chemical reactions, such as: 137178-88-2, name is 5-Bromopyridine-2-carbonyl chloride,molecular formula is C6H3BrClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 137178-88-2.

To a solution of 5-bromo-pyridine-2-carboxylic acid methyl ester [(L.] [OEQ.)] (see Synth. Commun., [1997,] [27,] 515) in THF : MeOH (2: 1; 0.2M) was added aqueous LiOH (1M ; 3. [0EQ.).] The mixture was stirred for 12h, concentrated and dried under vacuum. The residue was diluted in CH2CI2 (0.2M), oxalyl chloride [(8.] [OEQ.)] was added and the mixture was stirred for 3h, concentrated, dried under vacuum and diluted in [CH2C12] (0.2M). Cyclopropylamine [(LOEQ.)] was added and the mixture was stirred for 2h, poured in saturated aqueous [NAHC03] and extracted with EtOAc (2x). The combined organic extracts were washed with brine, dried over [NA2S04,] filtered and concentrated. Flash chromatography (CH2Cl2 : EtOAc; 9: 1) afforded the title compound as a yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 137178-88-2, 5-Bromopyridine-2-carbonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK FROSST CANADA & CO.; DESCHENES, Denis; DUBE, Daniel; DUBE, Laurence; GALLANT, Michel; GIRARD, Yves; LACOMBE, Patrick; MACDONALD, Dwight; WO2004/814; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 137178-88-2 ,Some common heterocyclic compound, 137178-88-2, molecular formula is C6H3BrClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution/suspension of 5-bromo-2-pyridinecarboxylic acid (0.2 g, 1 mmol) in CH2Cl2 (25 mL) was added oxalyl chloride (0.26 mL, 3 mmol) and 1 drop of DMF. Gas evolved and the all the solids dissolved. After Ih the reaction was evaporated and pumped. This material was dissolved/suspended in CH3CN (10 mL) then Intermediate C (0.25 g, 1 mmol) and diisopropylethylamine (2 mL) were added. A white solid formed(DIEA.HCl). After 1.5 h the reaction was filtered and the filtrate was evaporated, taken up in CH2Cl2, filtered and chromatographed on silica gel, eluting with a gradient of 0-10% methanol +1% ammonium hydroxide in CH2CI2. The product fractions were evaporated, dissolved in CBD2CI2, washed with 1 M NaOH (to remove residual hydrochloride salt) and evaporated to afford 0.25g of 24A (58% yield). 1H NMR (300 MHz, DMSOd5) 69.30 (t, /= 6.4 Hz, IH), 8.78 (d, J= 2.1 Hz, IH), 8.25(dd, J= 2.3 Hz, J= 8.2 Hz, IH), 7.98 (d, J= 8.3 Hz, IH), 7.19 (t, J= 7.8 Hz, IH), 6.88 – 6.80 (m, 2H), 6.74 – 6.68 (m, IH), 4.50 (t, J= 4.9 Hz, IH), 4.43 (d, J= 6.4 Hz, 2H), 3.03 – 2.96 (m, 2H), 2.52 – 2.47 (m, 3H), 2.03 – 1.87 (m, 6H), 1.77 – 1.68 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,137178-88-2, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; WO2007/78251; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem