Category: 137640-84-7

Synthetic Route of 137640-84-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 137640-84-7, name is 6-(3-(Trifluoromethyl)phenoxy)picolinic acid. This compound has unique chemical properties. The synthetic route is as follows.

To a 500 mL three-necked flask was added 2-(3-trifluoromethylphenoxy)-6-pyridinecarboxylic acid 28.3 g (0.1 mol),Bis(trichloromethyl) carbonate 11.9 g (0.04 mol) and150 mL of ethyl acetate, magnetically stirred and heated to 35 C.0.3 g of triethylamine was added dropwise, and the reaction was kept at 50 C for 2 h after the addition.Until the bubble stops, the reaction solution is clarified by white turbidity.Then purge the residual hydrogen chloride and phosgene with nitrogen.Standby after cooling.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 137640-84-7, 6-(3-(Trifluoromethyl)phenoxy)picolinic acid.

Reference:
Patent; Hebei University; Li Wan; Yang Zihui; Yang Fenglin; (6 pag.)CN108794390; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 137640-84-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 137640-84-7, name is 6-(3-(Trifluoromethyl)phenoxy)picolinic acid. A new synthetic method of this compound is introduced below.

EXAMPLE 24 Preparation of N-(2,4-difluorophenyl)-2-(3-alpha,alpha,alpha-trifluoromethylphenoxy)-6-pyridinecarboxamide 6-(3-alpha,alpha,alpha-Trifluoromethylphenoxy)picolinic acid (7.1 g) in thionyl chloride (50 ml) was refluxed for 1 hour. The excess thionyl chloride was evaporated in vacuo and dichloromethane added to the residual picolinoyl chloride. A solution of 2,4-difluoroaniline (3.3 g) and triethylamine (2.6 g) in dichloromethane (50 ml) was then added dropwise with stirring at ambient temperature. After stirring a further 1 hour, the reaction mixture was washed with water, dried over anhydrous magnesium sulphate and the dichloromethane evaporated. The residue was purified on a silica gel column using dichloromethane as eluant to give the title compound (6.9 g) as a white solid of melting point 110-111 C. m/e Theory: Found 394:394

At the same time, in my other blogs, there are other synthetic methods of this type of compound,137640-84-7, 6-(3-(Trifluoromethyl)phenoxy)picolinic acid, and friends who are interested can also refer to it.

Reference:
Patent; Shell Research Limited; US5294597; (1994); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem