Category: 138116-34-4

Adding a certain compound to certain chemical reactions, such as: 138116-34-4, (4-Aminopyridin-3-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 138116-34-4, blongs to pyridine-derivatives compound. Product Details of 138116-34-4

General procedure: To a solution of 2-aminobenzyl alcohol (1.0 mmol, 1.00 equiv) and MnO2 (3.0 equiv.) in dry CH2Cl2 (20 mL) were stirred for 18 h at room temperature. The completion of reaction was monitored by TLC analysis. After the completion of reaction solvent was evaporated under reduced pressure at 40C and taken up for next step without any purification. 50 mL of methanol was added to same round bottom flask and corresponding aryl amines (1.0 equiv.), isocyanides (1.0 equiv.) and pTSA (15 mol%) added sequentially and the reaction mixture was stirred at room temperature for 12-15h. After the completion of reaction (monitored by TLC), the solvent of reaction mixture was evaporated under reduced pressure at 45oC to afford a black residue which was purified by column chromatography on silica gel (230-400 mesh) by eluting with gradient solution of hexane/EtOAc to get pure compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,138116-34-4, (4-Aminopyridin-3-yl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Dev, Kapil; Ramakrishna; Maurya, Saransh Wales; Siddiqui, Ibadur Rahman; Kant, Ruchir; Maurya, Rakesh; Tetrahedron Letters; vol. 58; 12; (2017); p. 1202 – 1206;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 138116-34-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 138116-34-4 as follows.

Step 5: To a stirred solution of (4-aminopyridin-3-yl)methanol (200 mg, 1.61 mmol) in dimethylformamide were added imidazole (219 mg, 3.22 mmol, 2 eq) and tert-butyldimethylchlorosilane (267 mg, 1.77 mmol, 1.1 eq). The reaction mixture was stirred at room temperature for 5 h. The mixture was dissolved in ethylacetate and washed with water several times. The organic layer was dried over MgSO4 and filtered. The filtrate was removed in vacuo. The crude was purified by column chromatography get 3-((tert-butyldimethylsilyloxy)methyl)pyridin-4-amine (325 mg, 85%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,138116-34-4, its application will become more common.

Reference:
Patent; Gruenenthal GmbH; FRANK, Robert; Christoph, Thomas; Lesch, Bernhard; Lee, Jeewoo; US2013/29961; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem