Category: 13958-86-6

Adding a certain compound to certain chemical reactions, such as: 13958-86-6, 5-Methylpyridine-3,4-diamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Methylpyridine-3,4-diamine, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Methylpyridine-3,4-diamine

Aquo composite of 7-methyl-1H-[1,2,3]triazolo[4,5-c]pyridinium nitrate was obtained from 5-methylpyridine-3,4-diamine. 19 mmol (2.4 g) of this substrate were dissolved in 75 mL of water and 3 mL of concentrated H2SO4 acid was added. This solution was cooled to 0 C and then a solution made from 15 mL of water and 30 mmol (2.1 g) of NaNO2 was added dropwise. The mixture was stored at room temperature for 0.5 h, vaporized to its half volume and neutralized with KHCO3. After filtration 1.9 g of powder (melting point 260 C with its decomposition) was obtained. The yield of this synthesis was 73%. The obtained composite was recrystallized from a small amount of water. It is well soluble in water and alcohol but hardly soluble in benzene and chloroform. The transformation process of the cationic unit of the composite is described in Scheme 1 [53].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13958-86-6, 5-Methylpyridine-3,4-diamine, and friends who are interested can also refer to it.

Reference:
Article; Dymi?ska, Lucyna; Sheweshen, Khalil Salem M.; G?gor, Anna; Lorenc, Jadwiga; Hanuza, Jerzy; Journal of Molecular Structure; vol. 1133; (2017); p. 9 – 17;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 13958-86-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13958-86-6, name is 5-Methylpyridine-3,4-diamine. This compound has unique chemical properties. The synthetic route is as follows.

7-Methyl-1,3-dihydro-2H-imidazo[4,5-c]pyridine-2-thione (Compound 8): To a solution of 5-methylpyridine-3,4-diamine (100 mg, 0.812 mmol) and N,N-dimethylpyridin-4-amine (109 mg, 0.893 mmol) in MeCN was added di(1H-imidazol-1-yl)methanethione (217 mg, 1.218 mmol) portionwise. The mixture was stirred at room temperature for 4 h. The precipitate formed was filtered, washed with water, Et2O, DCM and dried to give 7-methyl-1H-imidazo[4,5-c]pyridine-2 (3H)-thione (100 mg, 75% yield) as a pale red solid. 1H-NMR (400 MHz, DMSO-d6) delta ppm 12.73 (brs, 2H), 8.20 (s, 1H), 8.06 (s, 1H), 2.33 (s, 3H); ESI-MS: m/z 165.84 (M+H)+.

According to the analysis of related databases, 13958-86-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Stingray Therapeutics, Inc.; The University of Utah; Vankayalapati, Hariprasad; Liu, Xiaohui; Ramamoorthy, Gurusankar; Sharma, Sunil; Kaadige, Mohan Rao; Weston, Alexis; Thode, Trason; (59 pag.)US2019/31655; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 13958-86-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13958-86-6, name is 5-Methylpyridine-3,4-diamine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 5-methylpyridine-3,4-diamine (100 mg, 0.81.2 mmol) and N,N dimethylpyridin-4-amine (109 mg, 0.893 mmol) in MeCN was added di(l H-imidazol-1-yl)methanethione (217 mg, 1.218 mmol) portionwise. The mixture was stirred at room temperature for 4 h. The precipitate formed was filtered, washed with water, Et2O, DCM and dried to give 7-methyl-1H-imidazo[4,5-c]pyridine-2(3H)-thione (100 mg, 75% yield) as a pale red solid. 1H-NMR (400 MHz, DMSO-d6) delta ppm 12.73 (brs, 2H), 8.20 (s, 1H), 8.06 (s, 1H), 2.33 (s, 3H); ESI-MS: m/z 165.84 (M+H)+.

According to the analysis of related databases, 13958-86-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Stingray Therapeutics, Inc.; Vankayalapati, Hariprasad; Sharma, Sunil; Kaadige, Mohan Rao; Weston, Alexis; Thode, Trason; (117 pag.)US2020/39979; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 13958-86-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13958-86-6, name is 5-Methylpyridine-3,4-diamine, molecular formula is C6H9N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The cyclization with 2,3-difluorbenzoic acid in PPA was performed as described above. Purified by column chromatography (silica gel, eluent: dichloromethan/methanol = 12/1). Yield: 22.2%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13958-86-6, 5-Methylpyridine-3,4-diamine.

Reference:
Patent; K.U. LEUVEN RESEARCH & DEVELOPMENT; GILEAD SCIENCES, INC.; PUERSTINGER, Gerhard; WO2005/63744; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 13958-86-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13958-86-6, name is 5-Methylpyridine-3,4-diamine. A new synthetic method of this compound is introduced below.

3,4-diamino-5-methylpyridine (413 mg, 3.35 mmol)Mixed with 20 ml of dimethyl oxalate,Warm to reflux and stir for 3-4 hours.After the reaction solution was cooled, the resulting solid was filtered off.The solid was dispersed in 15 ml of N,N-dimethylformamide.Add 1 g of activated carbon, raise the temperature to reflux, and filter it hot after 1 hour.Add 1 ml of water to the filtrate.Allow to stand for 1 hour,The precipitated white solid is filtered,Washed with water, washed with 95% ethanol,Ethyl acetate wash to give 8-methyl-6-azaquinoxaline-2,3-dione white solid(434 mg, yield 73.1%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13958-86-6, 5-Methylpyridine-3,4-diamine, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Jiao Tong University; Wang Yongxiang; Fu Lei; Xie Dongsheng; Lu Jun; (37 pag.)CN103435561; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem