Category: 139585-70-9

Related Products of 139585-70-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 139585-70-9, name is 6-Bromonicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

Under an argon atmosphere, tert-butyl (2-{methyl[3-(2-piperazin-1-ylpyrimidin-5-yl)benzyl]amino}-2-oxoethyl)carbamate (200 mg) and 6-bromonicotinonitrile (124 mg) were dissolved in toluene (6 ml), and tris(dibenzylideneacetone) dipalladium (124 mg), 1,1′-binaphthalene-2,2′-diylbis(diphenylphosphine) (169 mg), and cesium carbonate (222 mg) were added thereto, followed by stirring at 100 C. for 6 hours. The solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (0% to 7% MeOH/CHCl3) to obtain tert-butyl {2-[(3-{2-[4-(5-cyanopyridin-2-yl)piperazin-1-yl]pyrimidin-5-yl}benzyl)(methyl)amino]-2-oxoethyl}carbamate (122 mg).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 139585-70-9, 6-Bromonicotinonitrile.

Reference:
Patent; Astellas Pharma Inc.; US2012/184520; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 139585-70-9, name is 6-Bromonicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows. name: 6-Bromonicotinonitrile

lOld (59 mg, 0.19 mmol), 2-bromo-5-cyanopyridine (52 mg, 0.28 mmol), trans- dichlorobis(triphenylphosphine)palladium (II) (14 mg, 0.02 mmol), and copper(I) iodide (6 mg, 0.03 mmol) were mixed in a round bottom flask and placed under a nitrogen atmosphere. THF (1 mL) and triethylamine (0.053 mL, 0.380 mmol) were added, and the reaction mixture was stirred at 60 C for 1.5 hours. The reaction mixture was cooled to room temperature and diluted with EtOAc. The mixture was washed with sat’d aqueous NH4CI followed by brine, dried over MgSO/i, filtered, and concentrated in vacuo. Chromatographic purification of the residue (silica gel, 0 to 50% EtOAc in heptane) gave 6-((3-((lS,5S,6S)-3-amino-l,5- bis(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4- fluorophenyl)ethynyl)nicotinonitrile (101, 33 mg, 0.08 mmol, 42% yield) as an off-white solid. LC/MS (ESI+) m/z = 413.1 [M+H]+. NMR (400 MHz, DMSO-d6) delta ppm 9.05 (d, J = 1.37 Hz, 1H) 8.38 (dd, J = 8.22, 2.15 Hz, 1H) 7.96 (dd, J = 7.63, 2.15 Hz, lH) 7.85 (d, J = 8.22 Hz, 1H) 7.67 (ddd, J = 8.31, 4.50, 2.25 Hz, 1H) 7.35 (dd, J = 11.93, 8.41 Hz, 1H) 6.54 (s, 2H) 4.58 – 4.77 (m, 2H) 4.38 – 4.58 (m, 2H) 1.85 (t, J = 8.12 Hz, 1H) 1.19 (dd, J = 9.68, 5.38 Hz, 1H) 0.58 – 0.64 (m, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 139585-70-9.

Reference:
Patent; AMGEN INC.; ALLEN, Jennifer R.; AMEGADZIE, Albert; BOURBEAU, Matthew P.; CHEN, Jian J.; FROHN, Michael J.; HARRINGTON, Paul E.; LOW, Jonathan D.; MA, Vu V.; NGUYEN, Thomas T.; PICKRELL, Alexander J.; REEVES, Corey; (122 pag.)WO2018/112086; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 139585-70-9 ,Some common heterocyclic compound, 139585-70-9, molecular formula is C6H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

10 mmol, 1.58 g), Na2CO3 (0.5 mmol, 57 mg), 2-bromo-5-cyanopyridine(0.1 mmol, 115 mg) was dissolved in a mixed solvent of toluene / ethanol / water (V: V = 5: 2: 1). After 24 hours of refluxing, the reaction was stopped and the reaction mixture was left to stand at room temperature , Washed with dichloromethane, and then the organic phase was collected and purified by silica gel column chromatography to obtain 2.1 g of 2- (2 ‘, 4’-difluorophenyl) -5-amidopyridine as a white solid (yield : 89%);

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,139585-70-9, its application will become more common.

Reference:
Patent; UNIVERSITY OF SCIENCE AND TECHNOLOGY OF SUZHOU; ZHOU, YUYANG; WANG, XIAOMEI; YE, CHANGQING; ZHU, SAIJIANG; LIANG, ZUOQIN; (6 pag.)CN104016914; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 139585-70-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 139585-70-9, name is 6-Bromonicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

Example 10: [6-cyano-3-(4-methanesulfonylbenzyl)-2-methylindolizin-1- yl]acetic acid30Preparation 10a: 3-(5-cyanopyridin-2-yl)propionic acid ethyl ester A solution of 3-ethoxy-3-oxopropylzinc bromide in tetrahydrofuran (0.5 M, 60 ml_) was added dropwise over a period of 45 minutes to a mixture of 6- bromonicotinonitrile (5.0 g), tetrakis(triphenylphosphine)palladium(0), (0.69 g) and tetrahydrofuran (20 ml_) at room temperature and the resulting mixture was stirred at room temperature for 6 hours. The mixture was diluted with water (150 ml_), basified by the addition of saturated aqueous sodium hydrogen carbonate solution and extracted with methyl te/t-butyl ether. The combined extracts were dried over magnesium sulfate and the solvent removed under reduced pressure. Purification of the residue by column chromatography on silica gel, eluting with a mixture of pentane, dichloromethane and ethyl acetate (2:1 :0, 0:1 :0 and 0:5:1 by volume) gave title compound as a pale yellow oil, 4.1 g.1H NMR (CDCI3): delta 1.25 (m, 3H), 2.85 (t, J = 7.2 Hz, 2H), 3.2 (t, J = 7.2 Hz, 2H), 4.15 (m, 2H), 7.35 (d, J = 8.0 Hz, 1 H), 7.85 (m, 1 H), 8.80 (s, 1 H). MS: ESI (+ve) (Method B): 205 (M+H)+, Retention time 2.7 min.

According to the analysis of related databases, 139585-70-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ARGENTA DISCOVERY LIMITED; WO2008/74966; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 139585-70-9, 6-Bromonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H3BrN2, blongs to pyridine-derivatives compound. HPLC of Formula: C6H3BrN2

0.54 g of intermediate 3-1,0.28 g of 2-bromo-5-cyanopyridine, 1.28 g of tripotassium phosphate,And 0.15 g of [1,1-bis (diphenylphosphino) ferrocene] palladium dichloride,10 mL of DME was added. The mixture was stirred at 80 C. for 2 hours,After cooling to room temperature, water was added and the mixture was extracted with ethyl acetate.The obtained organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure.The obtained residue was subjected to silica gel chromatography (hexane: ethyl acetate = 1: 3) to obtain 0.26 g of the active compound A-52 shown below.

The synthetic route of 139585-70-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; MURAKAMI, SHINICHIRO; (291 pag.)JP2018/76354; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 139585-70-9, name is 6-Bromonicotinonitrile, the common compound, a new synthetic route is introduced below. HPLC of Formula: C6H3BrN2

Step B6-(8-hydroxy-1 ,4-dioxaspiro[4.5]dec-8-yl)nicotinonitrile. A solution of 6- bromonicotinonitrile (2 g, 1 1 mmol) in 50 ml. of dry THF and 15 ml. of dry hexane under argon was cooled to -100 C in a liquid nitrogen-Et20 bath. n-Butyllithium (7.5 ml_, 1 1 mmol, 1.6 M solution in hexane) was added dropwise so that the internal temperature did not exceed -95 C. The orange solution was stirred for an additional 10 min at -100 C to -95 C and then treated dropwise over 10 min with a solution of 1 ,4-cyclohexanedione monoethylene ketal (1 .8 g, 1 1 mmol) in 55 ml. of dry THF, again carefully maintaining the temperature below -95 C. The reaction mixture was stirred for 10 min at -100 C to -95 C, allowed to warm to 20 C and poured into ice water (400 ml_). The organic layer was separated, and the aqueous layer was extracted twice with Et20 (200 ml_). The combined organic extracts were dried over MgS04 and evaporated to give 2.8 g of white crystalline solid. Trituration with Et20 afforded 1 .9 g (67% yield) of white crystals: MS: (M+H)+ 261 .

The synthetic route of 139585-70-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; BURGESS, Gary; WO2012/114223; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem