Category: 141-86-6

Electric Literature of 141-86-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 141-86-6 as follows.

8.9 2-Amino-7-hydroxy-1,8-naphthyridine 2,6-Diaminopyridine (20?g, 0.18?mol) and (dl)-malic acid (27?g, 0.2?mol) were placed into a 500?mL three-neck round bottomed flask fitted with an addition funnel, thermometer, and mechanical stirrer. The stirred mixture was cooled in an ice-water bath and concentrated sulfuric acid (100?mL) was added drop-wise. The rate of addition was controlled to maintain an internal temperature ?45?C during the addition. Next, the addition funnel was replaced by a reflux condenser and the slurry was heated to an internal temperature of 110?C for 3?h. The solution was transferred to a 1L beaker, cooled to 0?C by an ice-water bath and was made basic (pH?=?8) by careful addition of NH4OHaq (300?mL). The crude brown solid was collected by vacuum filtration and was washed on the filter-paper with water (2?L). The solid was triturated with 1:9 (v:v) water: methanol and again collected by vacuum filtration, affording 7-amino-2-hydroxy-1,8-naphthyridine as a tan powder. Yield: 25?g (86%). 1H NMR (500?MHz, DMSO-d6): delta?=?11.91 (br s, 1H), 7.65 (d, J?=?9.5, 1H), 7.65 (d, J?=?8, 1H), 7.03 (br s, 2H), 6.34 (d, J?=?8.5, 1H), 6.12?ppm (d, J?=?9.2, 1H); 13C NMR (126?MHz; DMSO-d6): delta?=?163.8, 160.6, 150.4, 139.8, 137.4, 114.8, 105.3, 105.0?ppm; MS (ESI; CH3OH): m/z 162.0664 ([M+H]+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,141-86-6, its application will become more common.

Reference:
Article; Sarkar, Mithun; Pandey, Pragati; Bera, Jitendra K.; Inorganica Chimica Acta; vol. 486; (2019); p. 518 – 528;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 141-86-6, 2,6-Diaminopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2,6-Diaminopyridine, blongs to pyridine-derivatives compound. Application In Synthesis of 2,6-Diaminopyridine

In a 100 mL three-necked round bottom flask, acetic anhydride (2.1 ml, 27.5 mmol) in 20 mL THF was added dropwise to a stirred mixture of pyridine-2,6-diamine (3.00 g, 27.5 mmol) and triethylamine (2.78 g, 27.5 mmol) in THF (40 ml) at 0C. After the reaction mixture was stirred at room temperature overnight, it was diluted with water (10 mL) and extracted with ethyl acetate (3 x 20 mL). The combined organic layers were washed with brine (2 x 1 OmL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with ethyl acetate/petroleum ether (10/i) to give the title compound as a solid. LCMS (ESI) calc?d for C7H9N30 [M+i ]: 152 found: 152; ?H NMR (300 MHz, CD3OD): oe7.38-7.32(m, 1H),718(d, J= 7.8 Hz, 1H), 6.24 (d,J= 8.1 Hz, 1H),2.08(s,3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,141-86-6, 2,6-Diaminopyridine, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BENNETT, Frank; JIANG, Jinlong; PASTERNAK, Alexander; DONG, Shuzhi; GU, Xin; SCOTT, Jack D.; TANG, Haiqun; ZHAO, Zhiqiang; HUANG, Yuhua; HUNTER, David; YANG, Dexi; ZHANG, Zhibo; FU, Jianmin; BAI, Yunfeng; ZHENG, Zhixiang; ZHANG, Xu; YOUNG, Katherine; XIAO, Li; (580 pag.)WO2016/206101; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 141-86-6, name is 2,6-Diaminopyridine, the common compound, a new synthetic route is introduced below. name: 2,6-Diaminopyridine

N,N’-(pyridine-2,6-diyl)bis(2,2-dimethylpropanamide) (S17). Trimethylacetyl chloride (4.40mL, 36 mmol) was added to a stirred solution of 2,6 diaminopyridine (1.64 g, 15 mmol) andtriethylamine (6.30 mL, 45 mmol) in dichloromethane at 0 C. The solution was allowed to stir atroom temperature for 21 hours. The reaction mixture was washed with water and back extractedwith dichloromethane. The product was purified by column chromatography eluting with 20%ethyl acetate/hexanes to yield S17 (3.67, 13.2 mmol, 88%) as a light yellow solid.Rf: 0.28 (20% ethyl acetate/hexanes).1H NMR (600 MHz, CDCl3): delta =7.92 (d, J = 8.1 Hz, 2H), 7.73 (s, 2H), 7.69 (t, J = 8.1 Hz, 1H),1.32 (s, 18H)13C NMR (150 MHz, CDCl3): delta = 176.9, 149.8, 140.9, 109.5, 39.9, 27.6

The synthetic route of 141-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Fosu, Stacy C.; Hambira, Chido M.; Chen, Andrew D.; Fuchs, James R.; Nagib, David A.; Chem; vol. 5; 2; (2019); p. 417 – 428;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 141-86-6, name is 2,6-Diaminopyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 2,6-Diaminopyridine

Example 1 N, /V’-(pyridine-2, 6-diyl) dibenzamid 1) Synthetic Procedure: In a round bottom flask 2, 6-diaminopyridine (lg, 9.163 mmol) was dissolved in 40mL of dry dichloromethane and triethylamine (2.8mL, 27.72mmol) was added. Then, benzoyl chloride (2.5mL, 17.98 mmol) was added drop by drop and this mixture was stirred under inert atmosphere at room temperature for 15h. Reaction mixture was poured in water. Crude product was extracted in dichloromethane, organic layer was washed with water and dried over anhydrous sodium sulphate. The solvent was evaporated on rotary evaporator and crude product was purified by column chromatography on silica gel by eluting with ethyl acetate: hexane (40:60) mixture. The product was further purified by recrystallization using a methanol. Yield: 2.60 g (89%). NMR (200MHz, CDC13): delta ppm 7.54 (m, 6H), 7.90 (d, 4H, J=6Hz), 7.82 (t, 1H, J=8Hz), 8.10 (d, 2H, J=8Hz), 8.39 (s, 2H).

The synthetic route of 141-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; AMBADE, Ashootosh Vasant; PESALA, Bala; JOSHI, Kavita; BASUTKAR, Nitin Bapurao; RAY, Shaumik; DASH, Jyotirmayee; VILASRAO, Kaware Vaibhav; WO2015/104722; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 141-86-6, name is 2,6-Diaminopyridine. This compound has unique chemical properties. The synthetic route is as follows. 141-86-6

Preparation 44. N- (6-Amino-pyridin-2-yl) acetamide; Dissolve 2,6-diaminopyridine (9.822 g, 90 mmol) in dioxane (100 mL) and cool to 0C. Add acetyl chloride (2.355 g, 2.1 mL, 30 mmol) slowly and stir for 1 hr. at 0C. Remove the ice bath and stir at room temperature overnight. Quench the reaction mixture with saturated NaHCO3 solution, extract with ethylacetate three times. Combine the organic layers, dry over Na2S04, filter, and concentrate to give a solid. Chromatography on silica gel, eluting with a gradient of 60-70% ethylacetate in hexanes affords the title intermediate (3.45 g, 76%): mass spectrum (ion spray): m/z = 152. 1 (M+1) ; 1H NMR (CDC13, ppm): 7.49 (m, 3H), 6.28 (d, 1H), 4.31 (s, br, 2H), 2.19 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 141-86-6, 2,6-Diaminopyridine.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/35499; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

141-86-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 141-86-6, name is 2,6-Diaminopyridine, molecular formula is C5H7N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Diamine (1mmol), alcohol (2mmol), catalyst (1mol %), KOH (50mol %) and toluene (2mL) were placed in a 25mL round bottomed flask and stirred on a preheated oil bath (100C) for 12h. Upon completion (as monitored by TLC), the reaction mixture was cooled at ambient temperature, H2O (3mL) was added and the organic layer was extracted with ethyl acetate. The organic extract was separated, dried, and concentrated. The desired product was purified by column chromatography with CH2Cl2/EtOAc as eluent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 141-86-6, 2,6-Diaminopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ramachandran, Rangasamy; Prakash, Govindan; Nirmala, Muthukumaran; Viswanathamurthi, Periasamy; Malecki, Jan Grzegorz; Journal of Organometallic Chemistry; vol. 791; (2015); p. 130 – 140;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 141-86-6, name is 2,6-Diaminopyridine. This compound has unique chemical properties. The synthetic route is as follows. 141-86-6

2,6-diaminopyridine (5. 0g, 46 mmol) and chloroacetaldehyde (50% wt. soln in water, 6.4 mL, 50 mmol) were dissolved in absolute EtOH (120 mL). The solution was heated at 75 C for 1 hour. The mixture was cooled and concentrated via rotavap. The residue was taken up in saturated NaHCO3 and EtOAc. The solution was extracted with EtOAc (3 times), dried over magnesium sulfate, and concentrated to give a brown solid. 4.85g isolated (80% yield). 1H NMR (CDC13) 5 4.48 (s, 2H), 6. 10. (dd, J = 7.2, 1.2 Hz, 1H), 7.10-7. 20 (m, 2H), 7.42 (d, J = 1.2 Hz, 1H), 7.65 (d, J = 1.2 Hz, 1H). MS Calcd.: 133; Found: 134 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,141-86-6, 2,6-Diaminopyridine, and friends who are interested can also refer to it.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2005/44793; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

141-86-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 141-86-6, name is 2,6-Diaminopyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of Cu(OAc)2 (0.05 mmol, 0.0092 g) and potassium tert-butoxide (0.175 g, 2.5 mmol) in anhydrous dioxane (3 mL), the amine 1e (9.75 mmol) or the diamine 7 (2.5 mmol) and the correspondent alcohol 6 (2.5 mmol) or 2a (13 mmol) were added successively under inert argon atmosphere. After 4 days of reaction at 130 C, it was hydrolyzed with a saturated solution of ammonium chloride (10 mL). The mixture was extracted with AcOEt (3¡Á10 mL) and washed with brine (10 mL), after drying with anhydrous MgSO4 and filtering on Celite, the solvents were removed under low pressure (15-18 Torr). The resulting mixture was purified by column chromatography (if needed).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 141-86-6, 2,6-Diaminopyridine.

Reference:
Article; Martinez-Asencio, Ana; Ramon, Diego J.; Yus, Miguel; Tetrahedron; vol. 67; 17; (2011); p. 3140 – 3149;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem