McPherson, Kerry Silva’s team published research in ChemMedChem in 2021 | CAS: 141-86-6

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.COA of Formula: C5H7N3

McPherson, Kerry Silva; Zaino, Angela M.; Dash, Radha C.; Rizzo, Alessandro A.; Li, Yunfeng; Hao, Bing; Bezsonova, Irina; Hadden, M. Kyle; Korzhnev, Dmitry M. published an article in 2021. The article was titled 《Structure-Based Drug Design of Phenazopyridine Derivatives as Inhibitors of Rev1 Interactions in Translesion Synthesis》, and you may find the article in ChemMedChem.COA of Formula: C5H7N3 The information in the text is summarized as follows:

Rev1 is a protein scaffold of the translesion synthesis (TLS) pathway, which employs low-fidelity DNA polymerases for replication of damaged DNA. The TLS pathway helps cancers tolerate DNA damage induced by genotoxic chemotherapy, and increases mutagenesis in tumors, thus accelerating the onset of chemoresistance. TLS inhibitors have emerged as potential adjuvant drugs to enhance the efficacy of first-line chemotherapy, with the majority of reported inhibitors targeting protein-protein interactions (PPIs) of the Rev1 C-terminal domain (Rev1-CT). We previously identified phenazopyridine (PAP) as a scaffold to disrupt Rev1-CT PPIs with Rev1-interacting regions (RIRs) of TLS polymerases. To explore the structure-activity relationships for this scaffold, we developed a protocol for co-crystallization of compounds that target the RIR binding site on Rev1-CT with a triple Rev1-CT/Rev7R124A/Rev3-RBM1 complex, and solved an X-ray crystal structure of Rev1-CT bound to the most potent PAP analog. The structure revealed an unexpected binding pose of the compound and informed changes to the scaffold to improve its affinity for Rev1-CT. We synthesized eight addnl. PAP derivatives, with modifications to the scaffold driven by the structure, and evaluated their binding to Rev1-CT by microscale thermophoresis (MST). Several second-generation PAP derivatives showed an affinity for Rev1-CT that was improved by over an order of magnitude, thereby validating the structure-based assumptions that went into the compound design. The experimental process involved the reaction of 2,6-Diaminopyridine(cas: 141-86-6COA of Formula: C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.COA of Formula: C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tang, Jiali’s team published research in Environmental Research in 2022 | CAS: 141-86-6

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Name: 2,6-Diaminopyridine

In 2022,Tang, Jiali; Chen, Yingbi; Wang, Shixing; Kong, Desong; Zhang, Libo published an article in Environmental Research. The title of the article was 《Highly efficient metal-organic frameworks adsorbent for Pd(II) and Au(III) recovery from solutions: Experiment and mechanism》.Name: 2,6-Diaminopyridine The author mentioned the following in the article:

With the boom of modern industry, the demand for precious metals palladium (Pd) and gold (Au) is increasing. However, the discharge of Pd(II) and Au(III) wastewater has caused environmental pollution and shortage of resources. Here, a new metal-organic frameworks adsorbent (MOF-AFH) was synthesized to efficiently sep. Pd(II) and Au(III) from the water. The adsorption behavior of Pd(II) and Au(III) was explored at the same time. When gold and palladium are adsorbed sep., the adsorption capacity of gold and palladium is 389.02 mg/g and 191.27 mg/g, resp. The equilibration time is 3 h. When gold and palladium coexist, the adsorption capacities of Au(III) and Pd(II) are 238.71 and 115.02 mg/g, resp. The exptl. results show that the adsorption of Pd(II) and Au(III) on MOF-AFH is a single-layer chem. adsorption, which is an endothermic process. MOF-AFH has excellent selectivity and after MOF-AFH is repeatedly used 4 times, the removal effect can still reach more than 90%. The adsorption mechanisms include reduction reaction and chelation with N and O-containing functional groups on the adsorbent. There is also electrostatic interaction for Au(III) adsorption. The adsorbent can be used to efficiently recover gold and palladium from wastewater. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Name: 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Name: 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Xiaoran’s team published research in Journal of Catalysis in 2019 | CAS: 141-86-6

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Reference of 2,6-Diaminopyridine

The author of 《Molecular-level design of Fe-N-C catalysts derived from Fe-dual pyridine coordination complexes for highly efficient oxygen reduction》 were Zhang, Xiaoran; Mollamahale, Yaser Bahari; Lyu, Dandan; Liang, Lizhe; Yu, Feng; Qing, Ming; Du, Yonghua; Zhang, Xinyi; Tian, Zhi Qun; Shen, Pei Kang. And the article was published in Journal of Catalysis in 2019. Reference of 2,6-Diaminopyridine The author mentioned the following in the article:

Iron-nitrogen-carbon (Fe-N-C) materials as the most promising non-precious metal catalysts for oxygen reduction reaction (ORR) to replace Pt-based catalysts are in high demand for large scale application of fuel cells. However, their activity and durability are still critical issues. Development of Fe/N/C-containing precursors is a straightforward strategy for obtaining advanced Fe-N-C ORR catalysts to address these issues. Herein, we report an advanced Fe-N-C catalyst with a hybrid structure of single Fe atom sites (Fe-Nx moieties) and exposed Fe carbides/nitrides nanodots with diameters <2 nm embedded onto highly graphitic N-doped carbon matrix. The catalyst is synthesized by pyrolysis of a new kind of Fe-dual pyridine coordinated complex as the precursor. This facile chem. route results in a non-conventional Fe-N-C catalyst with encapsulated Fe-metallic phase nanoparticles or Fe-Nx moieties. The catalyst exhibits excellent ORR activity and remarkable durability in both acidic and alk. media. Its onset and half-wave potentials are 1.08 V and 0.88 V vs. (RHE) in 0.1 M KOH, resp., and 0.95 V and 0.81 V vs. RHE, resp., in 0.5 M H2SO4. Furthermore, a single proton exchange membrane (PEM) fuel cell fabricated by our catalyst generates the output power of 0.65 W cm-2, which indicates great potential of our hybrid structured Fe-N-C catalyst for the practical application in fuel cells. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Reference of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Reference of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Xing’s team published research in European Polymer Journal in 2021 | CAS: 141-86-6

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Category: pyridine-derivativesIn 2021 ,《Synthesis and application of self-healing elastomers with high healing efficiency and mechical properties based on multi-healing systems》 appeared in European Polymer Journal. The author of the article were Zhou, Xing; Wang, Hao; Li, Shaonan; Liu, Mengyue. The article conveys some information:

Intrinsic self-healing materials designed by combining reversible valence bonds or ionic coordination have attracted much attention due to their ability to recover from mech. damage. However, their mech. properties tend to deteriorate due to the increased rigidity of the chain. In this work, we report a self-healing polyurethane elastomer with multiple healing systems. 3,3′-dithiodipropionic acid (TDPA) and iron ion-2,6-diaminopyridine (DAP) were used as dynamic chain extenders and ionic ligands, resp. They can be effectively unsealed at a certain temperature to ensure that the self-healing efficiency is not affected by the material formula. By changing the content of hard and soft segments, the mech. properties and self-healing properties of the material can be adjusted in a large range. When the molar ratio of TDPA and DAP is 0.5:0.5, the polyurethane based on multiple healing system only needs to be healed at 70 °C for 12 h, and the self-healing efficiency can reach 93.48%. The structural rigidity and high reversibility of metal complexing agent DAP and iron ions play an important role in enhancing mech. strength and maintaining self-healing efficiency at 70 °C. Based on the above research, we prepared the strain sensor by combining self-healing polyurethane and conductive graphene. The sensor can respond to external force quickly and stably. This work provides a feasible strategy for the preparation of mech. robust polyurethane elastomers and self-healing flexible stress sensors with high self-healing efficiency at 70 °C. In the experiment, the researchers used 2,6-Diaminopyridine(cas: 141-86-6Category: pyridine-derivatives)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guillet, Gary L.’s team published research in Inorganic Chemistry in 2020 | CAS: 141-86-6

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.COA of Formula: C5H7N3

《Synthesis and Characterization of a Linear Triiron(II) Extended Metal Atom Chain Complex with Fe-Fe Bonds》 was written by Guillet, Gary L.; Arpin, Kathleen Y.; Boltin, Alan M.; Gordon, Jesse B.; Rave, Justin A.; Hillesheim, Patrick C.. COA of Formula: C5H7N3 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

Extended metal atom chain (EMAC) complexes of first-row transition metals with metal-metal bonds have the potential to elicit unique magnetic properties and reactivities. Until now, the library of EMAC complexes with late-first-row transition metals was incomplete because of the omission of a triiron species with Fe-Fe bonding. Herein we report the synthesis and preliminary investigation of the first linear, triiron(II) complex containing close Fe-Fe interactions. The complex is supported by three dianionic 2,6-bis[(trimethylsilyl)amido]pyridine ligands (L), with an overall composition of Fe3L3, and pseudohelical ligand coordination stabilizing the local trigonal-planar geometry at each iron. Fe3L3 was characterized by X-ray diffraction, 1H NMR, cyclic voltammetry, electronic absorption, and Mossbauer spectroscopies. Evans method anal. indicated a large uncompensated spin and an S = 6 ground state, suggesting ferromagnetic coupling in the triiron chain, likely due to direct exchange. The first structurally characterized triiron extended metal atom chain complex is presented. The complex is composed of three ferrous ions supported by three 2,6-bis[(trimethylsilyl)amido]pyridine ligands. The iron atoms are arranged linearly with two sym. Fe-Fe bonds of 2.437 Å indicative of modest single bonds. In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6COA of Formula: C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.COA of Formula: C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Senol, Dilek’s team published research in Journal of Fluorescence in 2020 | CAS: 141-86-6

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.COA of Formula: C5H7N3

《Synthesis, Structural Characterization, Enzymatic and Oxidative Polymerization of 2,6-Diaminopyridine》 was published in Journal of Fluorescence in 2020. These research results belong to Senol, Dilek. COA of Formula: C5H7N3 The article mentions the following:

Enzymic polymerization of 2,6-diaminopyridine (DAP) compound in the presence of HRP (Horse radish peroxidase) and H2O2 (hydrogen peroxide) with Poly(DAP-en) with the structures of two different types of polymers obtained by the oxidative polymerization of Poly(DAP-ox) using H2O2 in an aqueous basic environment was illuminated by 1H-NMR, 13C-NMR, FT-IR, UV-Vis spectral methods. GPC (gel permeation chromatog.), TGA (thermal gravimetric anal.), DSC (differential scanning calorimetry), CV (cyclic voltammetry), fluorescence anal. and conductivity measurements to characterize the compounds and their electronic structure were examined SEM analyzes were performed for the morphol. properties of the compounds As a result of the anal., it was observed that the polymer obtained by enzymic polymerization was better than the polymer obtained by oxidative method. It was observed that the results of the fluorescence measurements were better than Poly(DAP-en) in Poly(DAP-ox) emitting blue and green light. According to TGA anal., the first decay temperatures for poly(DAP-en) and poly(DAP-ox) were calculated as 342°C and 181°C, resp. The higher value of glass transition temperature for poly(DAP-en) confirms that the average molar mass is higher than 8650 Da for poly(DAP-en) according to GPC anal. The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6COA of Formula: C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.COA of Formula: C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dhiman, Nisha’s team published research in New Journal of Chemistry in 2019 | CAS: 141-86-6

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 2,6-Diaminopyridine

The author of 《A nitrogen and phosphorus enriched pyridine bridged inorganic-organic hybrid material for supercapacitor application》 were Dhiman, Nisha; Mohanty, Paritosh. And the article was published in New Journal of Chemistry in 2019. Safety of 2,6-Diaminopyridine The author mentioned the following in the article:

A new class of N- and P-enriched pyridine bridged inorganic-organic hybrid material is synthesized via the condensation of phosphonitrilic chloride trimer and 2,6-diaminopyridine at 140°C for 18 h. It was used as the active electrode material for supercapacitor application. The role of mass loading on the overall performance of the HPHM supercapacitor electrode has been investigated. Specific capacitances of 243 and 107 F g-1 are estimated from cyclic voltammetry and galvanostatic charge-discharge measurements at a scan rate of 1 mV s-1 and c.d. of 0.5 A g-1, resp. The high retention of 81% of the initial Csp value is observed after 2000 cycles at a c.d. of 5 A g-1. A fabricated solid-state sym. supercapacitor device made with the optimal mass loading shows power and energy densities of 244 W kg-1 and 14.4 W h kg-1, resp., and it could light up a green LED display (23 in total) for up to 50 s upon charging for 5 s at 3 V. After reading the article, we found that the author used 2,6-Diaminopyridine(cas: 141-86-6Safety of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mazur, D.’s team published research in Materials Today: Proceedings in 2019 | CAS: 141-86-6

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Synthetic Route of C5H7N3

In 2019,Materials Today: Proceedings included an article by Mazur, D.; Pariiska, O.; Kurys, Y.. Synthetic Route of C5H7N3. The article was titled 《Co-N-C electrocatalysts derived from nitrogen containing conjugated polymers for hydrogen evolution》. The information in the text is summarized as follows:

New Co-N-C electrocatalysts for hydrogen evolution reaction (HER) were successfully prepared via heat treatment of a series of nitrogen containing conjugated polymers – N-CP (poly-m-phenylenediamine, poly-8-aminoquinoline, poly-2,6-diaminopyridine, poly-5-aminoindole) with carbon black and Co(NO3)2. For the first time, we demonstrated influence of the N-CP type, like a nitrogen precursor, on activity toward HER of Co-N-C composites in acidic media, which may be related, in particular, to the differences in the mol. structure of polymers. It was found, that the best HER performance inherent to an electrocatalyst obtained based on poly-5-aminoindole (overpotential at 5 mA/cm2 ∼ 177 mV, Tafel slope – 132 mV/dec). According to obtained exptl. data, it was assumed that the hydrogen evolution on Co-N-C catalysts takes place by the Volmer-Heyrovsky mechanism and the Volmer step is rate-limiting. The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6Synthetic Route of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Synthetic Route of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Huang, Xinhua’s team published research in New Journal of Chemistry in 2019 | CAS: 141-86-6

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application of 141-86-6

Application of 141-86-6In 2019 ,《Molecular engineering of supercapacitor electrodes with monodispersed N-doped carbon nanoporous spheres》 was published in New Journal of Chemistry. The article was written by Huang, Xinhua; Wang, Nuoya; Li, Fei; Zhu, Xingxing; Liao, Kin; Chan, Vincent; Zhang, Lidong. The article contains the following contents:

Herein, a novel polytriazine compound was designed and used as a precursor for the synthesis of high nitrogen-doped porous carbon spheres (N-doped carbon-PNSs) by direct carbonization-activation; the process was simple and based on the template-free polycondensation of 2,6-diaminopyridine and formaldehyde in an aqueous solution Moreover, by varying the 2,6-diaminopyridine to formaldehyde ratio and total monomer concentration during the synthesis of the polymeric precursor, the size of the polytriazine nanospheres could be tuned from 102 to 3900 nm with a uniform spherical geometry. After pyrolysis, the N-doped carbon-PNSs had an average N content of 8.7-10.4 wt% and surface areas of 627.8-924.4 m2 g-1; most importantly, the N-doped carbon-PNSs as high energy supercapacitor electrodes exhibited excellent cyclability and high specific capacitance, ramping up to 424 F g-1 at 1 A g-1 in 6 M KOH. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Application of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bou-Puerto, Amelia’s team published research in Tetrahedron Letters in 2021 | CAS: 141-86-6

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 141-86-6

Product Details of 141-86-6In 2021 ,《6-Amino-7-azaindole synthesis from 2,6-diaminopyridine and diols》 appeared in Tetrahedron Letters. The author of the article were Bou-Puerto, Amelia; Bellezza, Delia; Martinez-Morro, Carlota; Gonzalez-Sanchis, Nerea; Ballesteros, Rafael; Cunat, Ana C.; Ballesteros-Garrido, Rafael. The article conveys some information:

6-Amino-7-azaindoles were prepared by dehydrogenative condensation of 2,6-diaminopyridine with diols. In addition, the similar reactions of 2-aminopyridines gave the corresponding pyrrolo[3,2-b]pyrroles. All these transformations were performed using accessible heterogeneous catalysts (Pd/C and ZnO).2,6-Diaminopyridine(cas: 141-86-6Product Details of 141-86-6) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem