Category: 141-86-6

Zhou, Su; Li, Rui; Zhang, Zhichao; Gu, Minyang; Zhu, Hongyan; Fang, Jing; Ji, Zhiwen; Xu, Xiaodong; Tang, Liming published an article in 2021. The article was titled 《Analysis of mutagenic components of oxidative hair dyes with the Ames test》, and you may find the article in Human & Experimental Toxicology.Application In Synthesis of 2,6-Diaminopyridine The information in the text is summarized as follows:

Oxidative hair dyes consist of two components (I and II) that are mixed before use. Aromatic amines in component I and their reaction with hydrogen peroxide after mixing them with component II have been of primary concern. In addition, two in vitro genotoxicity assays are still required for the approval of the final products of oxidative hair dyes in China, and the substance in the oxidative hair dye that causes the high rate of pos. results in genotoxicity tests, especially the Ames test, has not been fully elucidated. In this study, we analyzed the formulation of 55 different oxidative hair dyes from 7 color series and performed Ames tests in the strain TA98 with the S9 mix (oxidative hair dyes Number 1-30) and in strain TA97a without the S9 mix (oxidative hair dyes Number 31-55). We found that toluene-2,5-diamine sulfate (2,5-diaminotoluene sulfate, DATS) in component I may be the cause of mutagenicity in TA98, and hydrogen peroxide in component II may be the cause of mutagenicity in TA97a, and their pos. concentrations were consistent with those that we calculated from Ames tests. The results suggest that the pos. results for the oxidative hair dye in the Ames test were inevitable because of the existence of DATS in component I and of hydrogen peroxide in component II. Therefore, we should carry out safety assessments on each raw material and carry out risk assessments on the final products of oxidative hair dyes instead of genotoxicity tests in China. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Application In Synthesis of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application In Synthesis of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yadav, Eqvinshi; Khatana, Anil Kumar; Sebastian, Sharol; Gupta, Manoj K. published their research in New Journal of Chemistry in 2021. The article was titled 《DAP derived fatty acid amide organogelators as novel carrier for drug incorporation and pH-responsive release》.Related Products of 141-86-6 The article contains the following contents:

Inflammation is associated with many different class of diseases and NSAIDs (non-steroidal anti-inflammatory drugs) are mostly preferred for long-term use. Although they are safe to use, some serious side effects are associated with these class of compounds; therefore, local drug delivery is an option to minimize the side effects. In this study, we have designed a new gel formulation for topical and transdermal applications of the NSAIDs with enhanced properties. For this purpose, low mol. mass DAP (2,6-diaminopyridine) derived fatty acid amides with varying alkyl chain lengths are synthesized. These fatty acid amides form stable self-assembled aggregates in organic solvents as well as in organic and aqueous solvent mixtures affording organogels and bigels, resp. The min. gelation concentration (MGC) of the organic gel is 0.5% w/v, which behaves as a super gelator. The various functionality present in the DAP-derived fatty acid amide gelators play an important role in the self-aggregation such as pyridine moiety stack through π-π and alkyl chain via van der Waals interactions resulting in the formation of stable organo and bigels network. The prepared organogel emulsions with these fatty acid amides are capable to encapsulate and release the drug mol. ibuprofen at room temperature without altering its structure and activity. Therefore, these analogs can be successfully utilized in pharmaceutical industries as a novel drug delivery carrier.2,6-Diaminopyridine(cas: 141-86-6Related Products of 141-86-6) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Related Products of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Materials Today: Proceedings included an article by Zou, Faxing; Chen, Shaojun. Safety of 2,6-Diaminopyridine. The article was titled 《A Novel 2,6-Diaminopyridine-base Polymer with Thermo-/Water-responsive Shape Memory Effect》. The information in the text is summarized as follows:

Shape memory polymers with multiple stimuli have obtained increasing attention. This study illustrates a strategy for synthesizing polymers with thermo-/water-responsive shape memory effect. The novel polymer with excellent nature was proved to synthesized correctly using 2,6-diaminopyridine (DAP), polyethylene glycol (PEG1000) and hexamethylene diisocyanate (HDI). The result shows that the thermal stability of polyurethane can be improved with increasing of the DAP, embed into mol. chain. Moreover, the polymer which possesses excellent thermo-responsive, can be deformed and restored when in contact with water. The finding in this contribution, strongly promote diversified applications of shape-memory polymers, especially in engineering fields. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Safety of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Physical Chemistry C included an article by Xu, Xing; Lai, Lei; Jiang, Jiahong; He, Zhiqiao; Song, Shuang. Recommanded Product: 2,6-Diaminopyridine. The article was titled 《C,N-Codoped TiO2 with a Nitrogen-Doped Carbon Coating Derived from 2,6-Diaminopyridine for Visible Light-Induced Photocatalytic Hydrogen Evolution》. The information in the text is summarized as follows:

Nitrogen-doped carbon-wrapped C,N-codoped TiO2 (CN@C,N-TiO2) was successfully prepared using a facile and efficient method involving hydrolysis and calcination under Ar using tetra-Bu titanate and 2,6-diaminopyridine as the precursors. XPS and valence band XPS measurements reveal the successful codoping of interstitial carbon and nitrogen into TiO2, which leads to a visible-light absorption of up to ∼550 nm in the UV-vis diffuse reflectance spectra. Raman spectra and high-resolution TEM results show that N-doped carbon exists on the surface of C,N-TiO2, which gives rise to the efficient separation of photoexcited charge carriers, as determined by photoluminescence and electrochem. impedance spectroscopy. Benefiting from the combined effects of a surface-coated N-doped carbon layer and C,N-codoping, the photocatalyst calcined at 450° exhibits remarkable visible-light activity toward the hydrogen evolution reaction in the water splitting process with a H2 production rate of 833.2 μmol h-1 g-1 under 94 mW cm-2 visible-light illumination (λ > 420 nm). Moreover, the representative CN@C,N-TiO2 sample can maintain its activity for at least 40 h. After reading the article, we found that the author used 2,6-Diaminopyridine(cas: 141-86-6Recommanded Product: 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Recommanded Product: 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Organic Chemistry Frontiers included an article by Zhou, Chunhui; Hu, Jinsong; Wang, Yuan; Yao, Changguang; Chakraborty, Priyanka; Li, Huaifeng; Guan, Chao; Huang, Mei-Hui; Huang, Kuo-Wei. HPLC of Formula: 141-86-6. The article was titled 《Selective carbonylation of benzene to benzaldehyde using a phosphorus-nitrogen PN3P-rhodium(I) complex》. The information in the text is summarized as follows:

A PN3P pincer pyridinediamine ligand 2,6-(R2PNH)C5H3N (1; R = cyclopentyl, C5H5N = pyridine) bearing dicyclopentylphosphine substituents reacts with [Rh(COD)Cl]2 (COD = 1,5-cyclooctadiene) to produce the complex (PN3P)RhCl (2). Treatment of a benzene solution of 2 with KN(SiMe3)2 stimulates a dearomatization process, and C-H activation of benzene is achieved through the rearomatization of the central pyridine ring. This deprotonation/reprotonation of the NH arm of 2 gives the Ph complex (PN3P)Rh(C6H5) (3). The subsequent introduction of CO gas into 3 yields the benzoyl complex (PN3P)RhCO (C6H5) (4), which can release benzaldehyde upon treatment with diluted HCl solution and regenerates 2. The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6HPLC of Formula: 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.HPLC of Formula: 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C5H7N3In 2019 ,《Synthesis, Characterization and Fluorescence Quantum Yields of Thermally Resisted Shinning Polymers Containing Thiophene and Azomethine Units》 was published in Journal of Fluorescence. The article was written by Temizkan, Kevser; Kaya, Ismet. The article contains the following contents:

Poly(azomethine)s containing thiophene with bridges pyridine, sulfur and oxygen were synthesized in two steps. Before, thiophene centric dialdehyde (DIAL-Th) compound was synthesized via elimination reaction of 4-hydroxy benzaldehyde with thiophene bromide. Then, poly(azomethine)s containing thiophene (PAZ-Th) unit were synthesized from condensation reactions of DIAL-Th with pyridine-3,5-diamine, 4,4′-thiodianiline and 4,4′-oxydianiline. The obtained dialdehyde and poly(azomethine- thiophene)s were ratified by Fourier-transform IR spectroscopy (FT-IR), UV-visible spectroscopy (UV-Vis), hydrogen and carbon NMR spectroscopy. The some properties of poly(azomethine-thiophene)s were investigated such as optic, electronic, surface and thermal. Electrochem. and fluorescence properties of compounds were made by cyclic voltammetry (CV) and fluorescence anal., resp. According to fluorescence measurement, PAZ-Th-1 was interestingly demonstrated five different colors in DMF solution Blue, green, yellow, orange and red were observed at 420, 440, 480, 500 and 520 nm, resp., in this solution The fluorescence quantum yields of PAZ-Th-1 were found. According to thermogravimetric (TG) and differential scanning calorimetry (DSC) analyses, Tonset and glass transition temperature of PAZ-Th-1, PAZ-Th-2 and PAZ-Th-3 were found. Also, surface analyses of synthesized poly(azomethine-thiophene)s were photographed by scanning electron microscope (SEM) at room temperature The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6Electric Literature of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Electric Literature of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sidharaj, N.; Rajarajan, G.; Senthil, M. published their research in Materials Today: Proceedings in 2021. The article was titled 《Synthesis, characterization and Ion-exchange properties of 4, 4 oxy-dianiline, 2,6 diamino-pyridine with formaldehyde terpolymer》.Product Details of 141-86-6 The article contains the following contents:

A new terpolymer ligand (DAPR) was synthesized based on condensation polymerization techniques. DAPR was named by 4,4 oxy-dianiline and 2,6 diamino-pyridine with formaldehyde. The taken monomers mole ratio is 1:1:2 in the reaction medium of DMF. The solubility behavior of the terpolymer samples have been studied in various solvents. The prepared terpolymer ligand was characterized by elemental anal., FTIR, 1H & 13C NMR and TGA studies. The synthesized terpolymer ligand mol. formula identified by elemental anal. and the most probable structure confirmed by the spectral studies of FTIR, 1H & 13C NMR. The SEM image used to establish the outward of the ligand. The thermal decomposition and thermal strength of DAPR ligand was carried out by thermo gravimetric anal. (TG-DTA). The chelation ion exchange studies of the terpolymer for the definite metal ions were also carried out by batch equipoise way under the estimation of metal ion uptake at diverse electrolytes. The experimental process involved the reaction of 2,6-Diaminopyridine(cas: 141-86-6Product Details of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Konovalova, Irina S.; Muzyka, Ekaterina N.; Urzhuntseva, Victoriya V.; Shishkina, Svitlana V. published their research in Structural Chemistry in 2021. The article was titled 《Role of intermolecular interactions in formation of mono- and diaminopyridine crystals: study from the energetic viewpoint》.Computed Properties of C5H7N3 The article contains the following contents:

Abstract: The regularities of crystal structure organization in a series of mono- and diaminopyridines possessing biol. activities were studied using an approach based on comparison of interaction energies between mols. calculated by ab initio quantum chem. method. The presence of the pyridine nitrogen atom causes the formation of N-H…Npyr hydrogen bond which is the strongest in all the studied structures. Being amphiphilic in hydrogen bond formation, the amino group possesses acceptor properties only in meta-position to the pyridine nitrogen atom in mono-aminopyridines. The presence of the two amino groups results in increasing of acceptor properties of both ones. The N-H… Nlp hydrogen bonds bind primary BSM (basic structural motif) in the structures of 2,5-diaminopyridine, 2,4-diaminopyridine and 3,4-diamonpyridine and form the primary BSM alongside with N-H…Npyr hydrogen bond in the structure of 2,3-diaminopyridine. The helical primary basic structural motif and double helical secondary basic structural motif in the 2,3-diaminopyridine crystal structure are very similar to the DNA helix and double helix. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Computed Properties of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Computed Properties of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, characterization and SAR studies of bis(imino)pyridines as antioxidants, acetylcholinesterase inhibitors and antimicrobial agents》 was published in Bioorganic Chemistry in 2020. These research results belong to Milosevic, Milena D.; Marinkovic, Aleksandar D.; Petrovic, Predrag; Klaus, Anita; Nikolic, Milica G.; Prlainovic, Nevena Z.; Cvijetic, Ilija N.. Application of 141-86-6 The article mentions the following:

A series of sixteen bis(imino)pyridines (BIPs) I [R = Ph, 2-quinolyl, 1-naphthyl, etc.] was synthesized starting from 2,6-diaminopyridine and aromatic aldehydes, and evaluated for their antioxidant, antibacterial, antifungal and acetylcholinesterase (AChE) inhibitory activities. The formation of stable, carbon-centered radical cations in a solution was confirmed by ESR spectroscopy and DFT calculations The in vitro antioxidant potency was evaluated using four assays: free radical scavenging activity (DPPH and ABTS), reducing power and total antioxidant capacity assay. BIPs demonstrated excellent antioxidant properties, and two derivatives proved to be more potent than reference antioxidants (ascorbic acid and Trolox) in all assays. DFT calculations on ωB97XD/6-311++g(d,p) level of theory provided valuable insights into the radical scavenging mechanism of BIPs. For hydroxyl-substituted BIPs, hydrogen atom transfer (HAT) was a predominant mechanism, while the single electron transfer coupled with proton transfer (SET-PT) governed the antioxidant activity of other derivatives Intramol. hydrogen bonding (IHB) played an important role in the mechanism of antioxidant activity as revealed by noncovalent interaction anal. and rotational barrier calculations The spin d. of radical cations was localized on carbon atoms of a pyridine ring, which corroborated with g-factors and multiplicity obtained from ESR anal. The most potent compound I [R = 2-pyridyl] exhibited moderate inhibitory activity toward AChE (IC50 = 20 ± 4μM), while mol. docking suggested binding at the peripheral anionic site of AChE with the MMFF94 binding enthalpy of -43.4 kcal/mol. Moderate in vitro antimicrobial activity of BIPs had been determined against several pathogenic bacterial strains: Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus and clin. isolate of methicillin resistant S. aureus (MRSA). The antifungal activity of BIPs toward Candida albicans was also confirmed. The similarity ensemble approach combined with mol. docking suggested leucyl aminopeptidase as the probable antimicrobial target for the three most potent BIP derivatives I [R = 2-HOC6H4, 8-OH-2-quinolyl, 2-pyridyl]. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Application of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 141-86-6In 2019 ,《Excellent toughening of 2,6-diaminopyridine derived poly (urethane urea) via dynamic cross-linkages and interfering with hydrogen bonding of urea groups from partially coordinated ligands》 was published in Polymers (Basel, Switzerland). The article was written by Sun, Ailing; Guo, Wenjuan; Zhang, Jinping; Li, Wenjuan; Liu, Xin; Zhu, Hao; Li, Yuhan; Wei, Liuhe. The article contains the following contents:

Conventional approaches to synthesize thermoplastic polyurethane (TPU) with excellent robustness are limited by a competing relationship between soft and hard segments for tuning mech. properties in terms of chain flexibility and micro-phase separation Herein, we present a facile and effective way of simultaneously improving the tensile strength, elongation, and toughness by constructing dynamic cross-linkages from metal-ligand interaction between Zn2+ and pyridine moiety in backbone of poly(urethane urea) (PUU) derived from 2,6-diaminopyridine and poly(propylene glycol). It was found that a Zn2+/pyridine ratio of 1:4 is the most effective for improving robustness. Specifically, tensile strength, elongation, and toughness could be remarkably increased to 16.0 MPa, 1286%, and 89.3 MJ/m3 with 226%, 29%, and 185% increments compared to uncomplexed PUU, resp. Results from UV-vis, Fourier transform IR spectroscopy (FTIR), cyclic tensile tests, and stress relaxation reveal that metal-ligand interaction significantly interferes with the hydrogen bonding of urea groups, thus leading to weakening of stiffness. Furthermore, half of vacant ligands enable dynamic complexation during stretching, which consequently ensures constant noncovalent cross-linkages for constraining mutual chain sliding, contributing to simultaneous improvement of tensile strength, elongation, and toughness. This work provides a promising approach for designing TPU with excellent robustness. In the experiment, the researchers used 2,6-Diaminopyridine(cas: 141-86-6Application of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem