Category: 14121-36-9

Mack, Arthur G.; Suschitzky, Hans; Wakefield, Basil J. published the artcile< Polyhaloaromatic compounds. Part 43. Inter- and intramolecular reactions of polychloroaromatic compounds with copper>, Name: 2,3,4,6-Tetrachloropyridine, the main research area is Ullmann reaction polychlorohalopyridine copper; chlorohalopyridine Ullmann intermol reaction; pyridine polychloro halo Ullmann reaction.

The Ullmann reaction of 4-bromotetrachloropyridine with Cu in DMF gave products arising from halogen exchange and reduction reaction in addition to the expected coupled products whereas pentachloropyridines gave tetrachloropyridines only. The Ullmann reaction of 4-(o-halophenoxy)- and 4-(o-halothiophenoxy)tetrahalopyridines gave products arising from cyclization, reduction, and halogen transfer. Some Cu reacts initially with the pyridyl rather than the o-haloaryl group. The results suggest the Ullmann reaction proceeds by a mechanism involving a pyridylcopper intermediate. Nucleophilic substitution products of pentahalopyridines with phenols, thiophenols, and aniline, were obtained.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Name: 2,3,4,6-Tetrachloropyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ager, E.; Chivers, G. E.; Suschitzky, H. published the artcile< Photolysis of pentachloropyridine and pentachloropyridine 1-oxide>, Related Products of 14121-36-9, the main research area is chloropyridine irradiation; lithium chloropyridine; substitution nucleophilic chloropyridine; cleavage chloropyridine oxide photolysis.

Irradiation of pentachloropyridine in dioxane, Et2O, or cyclohexane gave 2,3,4,6-tetrachloropyridine (I), but irradiation of pentachloropyridine N-oxide in CCl4 gave Cl2C:CClCCl:CClNCO. I and BuLi gave (tetrachloro-3-pyridyl)lithium. With nucleophilic reagents I underwent substitution reactions; e.g., I with NaOH-MeOH gave 61% 2,3,6-trichloro-4-methoxypyridine.

Journal of the Chemical Society, Chemical Communications published new progress about Ring opening. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Related Products of 14121-36-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bratt, Jack; Iddon, Brian; Mack, Arthur G.; Suschitzky, Hans; Taylor, Jack A.; Wakefield, Basil J. published the artcile< Polyhaloaromatic compounds. Part 41. Photochemical dehalogenation and arylation reactions of polyhaloaromatic and polyhaloheteroaromatic compounds>, Recommanded Product: 2,3,4,6-Tetrachloropyridine, the main research area is photochem dehalogenation arylation haloarom compound; photocyclization thiopyridine; halobenzene poly photochem dehalogenation arylation; pyridine halo dehalogenation arylation.

Photolysis of pentachloro- and pentabromopyridine in Et2O led to β-halogen loss and the formation of a product of attack by Et2O, I (R = Cl, Br, resp.). Both 4-bromo- and 4-iodotetrachloropyridines underwent exclusive loss of Br and iodine, resp. Perhalothiophenes, tetrachloropyrimidine and C6Cl6 underwent similar dehalogenation reactions. Photolysis of C6Cl5I (II), tetrachloroiodopyridines and trichloro-5-iodothiophene in C6H6 gave the corresponding polychloroaryl- or polychloroheteroarylbenzenes. E.g., II underwent photolysis in C6H6 to give 95% 2,3,4,5,6-pentachlorobiphenyl. Photolysis of the pyridines III (R1 = SPh, SC6Cl5) gave the corresponding photocyclization products IV (R2 = H, Cl) resp.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Photochemical arylation. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Recommanded Product: 2,3,4,6-Tetrachloropyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Husain, Sajid; Krishnamurthy, A. S. R.; Sarma, P. Nageswara published the artcile< Separation and identification of chloropyridine isomers and quantitative determination of pentachloropyridine in chlorinated pyridine residues by gas chromatography-mass spectrometry>, Formula: C5HCl4N, the main research area is chloropyridine gas chromatog mass spectrometry.

Chloropyridine isomers (2,3,5-trichloropyridine 2,4,6-trichloropyridine, 2,3,4,6-tetrachloropyridine. 2,3,5,6-Tetrachloropyridine, and pentachloropyridine) were separated and identified by gas chromatog.-mass spectrometry in chlorinated pyridine residue. Stainless steel columns packed with 3% or 10% DEGA on Chromosorb WAW or PAW were used. Chloropyridine are intermediates in the preparation of pesticides, herbicides, dyes, pharmaceuticals, and plastics.

Journal of Chromatography published new progress about 14121-36-9. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Formula: C5HCl4N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pan, Sheng-Dong; Shen, Hao-Yu; Zhou, Li-Xin; Chen, Xiao-Hong; Zhao, Yong-Gang; Cai, Mei-Qiang; Jin, Mi-Cong published the artcile< Controlled synthesis of pentachlorophenol-imprinted polymers on the surface of magnetic graphene oxide for highly selective adsorption>, Synthetic Route of 14121-36-9, the main research area is pentachlorophenol imprinted polymer surface magnetic graphene oxide adsorption.

A novel, well-designed magnetic graphene oxide sheet embedded with core-shell molecularly imprinted polymer microspheres (MGO@MIP) was controllably synthesized via a reflux-precipitation polymerization and surface imprinting technique. The as-prepared MGO@MIP was fully characterized and the specific selectivity and remarkable adsorption capacity to pentachlorophenol (PCP) are closely related to the synergetic effect of hydrogen bonding and π-π interactions, which are strongly associated with the solution pH and the distribution of magnetic microspheres on the surface of GO sheets. Under the optimal conditions, i.e., pH of 4.0 and a ratio of monomers to Fe3O4 of 15, the maximum adsorption capacity and the imprinting factor (α) of MGO@MIP towards PCP were 789.4 mg g-1 and 4.36, resp. The newly synthesized MGO@MIPs proved to be a great adsorbent for PCP in environmental water.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Adsorption. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Synthetic Route of 14121-36-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Howard, Philip H.; Muir, Derek C. G. published the artcile< Identifying New Persistent and Bioaccumulative Organics Among Chemicals in Commerce>, Recommanded Product: 2,3,4,6-Tetrachloropyridine, the main research area is identifying new persistent bioaccumulative organic chem.

This work identified com. chems. which may be persistent and bioaccumulative (P&B) and are not being considered in current Great Lakes, North American, and Arctic pollutant measurement programs. The authors combined the Canadian Domestic Substance List (DSL; a list of 3059 substances of unknown or variable composition complex reaction products and biol. materials) and the USEPA Toxic Substances Control Act Inventory Update Rule database for years 1986, 1990, 1994, 1998, 2002, and 2006, yielding a database of 22,263 com. chems. From that list, 610 chems. were identified by estimates from USEPA EPISuite software and using expert judgment. This work yielded some interesting, probable P&B chems. which should be considered for addnl. study. Recent studies, following initial reports and presentations on this work, confirmed the environmental presence of many of these chems.

Environmental Science & Technology published new progress about Alcohols, C32-36-branched Role: NUU (Other Use, Unclassified), POL (Pollutant), PRP (Properties), USES (Uses), OCCU (Occurrence). 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Recommanded Product: 2,3,4,6-Tetrachloropyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 14121-36-9, Adding some certain compound to certain chemical reactions, such as: 14121-36-9, name is 2,3,4,6-Tetrachloropyridine,molecular formula is C5HCl4N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14121-36-9.

A mixture of 6-amino-1-methyl-4-((2-(pyrimidin-2-yl)propan-2-yl)amino)quinolin- 2(1H)-one (Intermediate A3a, 100 mg, 0.32 mmol), 2,3,4,6-tetrachloropyridine (84 mg, 0.39 mmol), NMP (3.2 mL) and triethylamine (90 uL, 0.65 mmol) was sealed in a vial and purged with argon for 5 mins. The vial was then heated in the microwave for 6h at i40C. Once cooled, DMSO (0.4 mL) was added to the sample which was purified directly using reverse-phase Ci8 column eluting from 30-iOO% methanol in water (each containing 0.i% formic acid) to give the title compound (52 mg) as a pale brown solid. 1H NMR (600 MHz, DMSO-d6) O 9.08 (5, iH), 8.82 (d, J = 4.9 Hz, 2H), 8.25 (d, J = 2.3 Hz, 1H), 7.53 (dd, J = 8.9, 2.3 Hz, 1H), 7.47 (d, J =8.9 Hz, 1H), 7.39 (t, J= 4.9 Hz, 1H), 6.87 (5, 1H), 6.43 (5, 1H), 4.69 (5,1H), 3.42 (5, 3H), i.76 (5, 6H). LCMS (Method T4) Rt = 2.95 mins, m/z 489.0749 [M+H] expected 489.0759 for C22H20Cl3N6O.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 14121-36-9, 2,3,4,6-Tetrachloropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; BELLENIE, Benjamin Richard; CHEUNG, Kwai Ming Jack; DAVIS, Owen Alexander; HOELDER, Swen; HUCKVALE, Rosemary; LLOYD, Matthew Garth; (360 pag.)WO2018/215798; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 14121-36-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14121-36-9, name is 2,3,4,6-Tetrachloropyridine, molecular formula is C5HCl4N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1: 100g of tetrachloropyridine, 0.5g of catalyst, 15g of acid binding agent,3g of auxiliary agent and 500g of organic solvent are placed in a 1L autoclave, and the autoclave is evacuated three times until the autoclave is in a vacuum state;The tetrachloropyridine is 2,3,4,6-tetrachloropyridine;The catalyst includes a supported activated carbon, a metal M1, a metal M2, and a metal M3 supported on the supported activated carbon,The metal M1 is Pd, the metal M2 is Ag, and the metal M3 is V,The mass percentage content of metal M1 in the catalyst is 2%, and the mass percentage content of metal M2 is 0.4%.The mass percentage of metal M3 is 0.15%; The acid binding agent is triethylamine and urea, and the mass ratio of the triethylamine and urea is 1: 1;The auxiliary is citric acid;The organic solvent is ethyl acetate; Step 2: Replace the high-pressure reactor after vacuuming in Step 1 with nitrogen for three times, and then replace with hydrogen for three times;Step three, continue to introduce hydrogen into the autoclave after the hydrogen replacement in step two, control the hydrogen pressure to 1.0 MPa, the temperature to 50 C., and react for 7 hours under the stirring condition, and reduce to room temperature;Step 4: Drain the hydrogen in the autoclave after the temperature drops to room temperature in Step 3, replace it with nitrogen for three times, filter the system in the autoclave to obtain the filtrate and the recovered catalyst, and reuse the recovered catalyst; Step 5. Distillate the filtrate in step 4 under reduced pressure to obtain 2,3-dichloropyridine as a white solid.The solvent obtained by vacuum distillation is recovered and reused; the vacuum of the vacuum distillation is -0.092 MPaThe temperature of the vacuum distillation was 40 C. The yield of 2,3-dichloropyridine was 98.1%, and the purity was 99.3%.

According to the analysis of related databases, 14121-36-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Xi’an Kaili New Materials Co., Ltd.; Li Xiaoan; Xiao Dawei; Han Bin; Zhang Yu; Zhang Zhixiang; Zeng Yongkang; Wan Kerou; Gao Wu; (13 pag.)CN110759859; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem