Category: 142-08-5

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 142-08-5, name is Pyridin-2(1H)-one, the common compound, a new synthetic route is introduced below. Formula: C5H5NO

(128-2) Under nitrogen atmosphere, to a solution of 2-hydroxypyridine (2.66 g) and NEt3 (4.05 mL) in THF (80 mL) was added dropwise SOCl2 (1.05 mL) under ice-cooling, and the mixture was stirred for one hour. The mixture was filtered, and the solvent was evaporated under reduced pressure to give di-2-pyridyl sulfite (3.02 g, 91 %).

The synthetic route of 142-08-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1479384; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 142-08-5, name is Pyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 142-08-5

3-l3romo-pyridin-2-ol. A stirred suspension of 2-pyridone (77-0, 19 g, 200 mmol) in 200 mE of 1 M aqueous K13r at room temperature was treated over 15 mm with bromine (32 g, 200 mmol; CAUTION: Large quantities of 13r2 should be handled careffilly) in 200 mE of 1 M aqueous K13r, then stirred vigorously at room temperature 0/N. After 24 h, this solution deposited crystals which were filtered off and then recrystallized from acetonitrile to give 27.2 g (78%) of 3-bromo- pyridin-2-ol. (77-1) [J. Am. Chem. Soc. 1982, 104, 4142- 4146; Bioorg. Med. Chem. Lett. 2002, 12, 197-200; JMed Chem. 1979, 22, 1284-1290.] Molecular weight calcd. for C5H4I3rNO: 173; (M+H) found: 174

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 142-08-5, Pyridin-2(1H)-one.

Reference:
Patent; Ocera Therapeutics, Inc.; Hoveyda, Hamid R.; Fraser, Graeme L.; Peterson, Mark; (171 pag.)US2018/110824; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 142-08-5, name is Pyridin-2(1H)-one. A new synthetic method of this compound is introduced below., 142-08-5

General procedure: To a stirred solution of substituted or unsubstituted 2-pyridone (1 eqiv) in acetic acid (10 ml) was added N-halosuccinamide (1.5 eqiv) and heated to 120 C overnight. The recation mixture was flitered,concentrated, diluted with saturated aqueous NaHCO3 and extracted twice with ethyl acetate. The combined ethyl acetate layers were washed with brine, dried over anhydrous sodium sulfate, filtered,concentrated and purified by combiflash to give C in good to excellent yields.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,142-08-5, Pyridin-2(1H)-one, and friends who are interested can also refer to it.

Reference:
Patent; PI INDUSTRIES LTD.; SHANBHAG, Gajanan; DODDA, Ranga Prasad; KAMBLE, Ganesh Tatya; KALE, Yuvraj Navanath; RENUGADEVI, G.; MANJUNATHA, Sulur G; S.P., Mohan Kumar; AUTKAR, Santosh Shridhar; GARG, Ruchi; VENKATESHA, Hagalavadi M; MAVINAHALLI, Jagadeesh Nanjegowda; KLAUSENER, Alexander G.M.; (161 pag.)WO2018/193387; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem