Category: 14237-71-9

Application of 14237-71-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14237-71-9, name is 2-Chloro-4,6-dimethylnicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: In a 100 mL round bottom flask, compound 2a (0.7 g, 4.0 mmol),P-methylaniline (1.3 g, 12.0 mmol) and DMSO (15 mL) were stirred and heated in an oil bath at 120 under N2 protection(The progress of the reaction was monitored by TLC, developing solvent: ethyl acetate: petroleum petroleum = 1: 10). After the reaction is completed, cool to room temperature.Extract with saturated NaHCO3 solution (3 × 30 mL) and DCM solution (5 × 30 mL), combine the organic phases,Wash with saturated NaCl solution 3 ~ 4 times, dry with anhydrous Na2SO4, and concentrate under reduced pressure.Purification by silica gel column chromatography (eluent: V ethyl acetate: V petroleum ether = 1: 45) to obtain compound 3aa as a white powder. Yield: 39%.

According to the analysis of related databases, 14237-71-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guilin Medical University; Huang Wanyun; Zhang Xiaoting; Zheng Bin; Lv Liang; Wang Shuqin; (17 pag.)CN110305128; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 14237-71-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14237-71-9, name is 2-Chloro-4,6-dimethylnicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

2-chloro-4,6-dimethyl-nicotinonitrile (2.5 g, 15.01 mmol) was dissolved in anhydrous methanol (70mL), added with sodium methoxide (4. 27 g, 75.03 mmol) at 0 C and stirred for about 10 hours at nitrogen atmosphere. The above mixture was concentrated under reduced pressure and then neutrailized with a saturated solution of ammonium chloride and then extracted twice with 150 mL of methylenechloride. The resulting organic layer was dried using anhydrous sodium sulfate, filtered and concentrated. A silica gel column chromatography (20% EtOAc/Hexanes) was performed on the resulting residue and 2.41g (99%) of 2- methoxy-4, 6-dimethyl-nicotinonitrile was obtained in white solid. ‘H NMR (300 MHz, CDC13) 8 2.44 (s, 3H), 2.45 (s, 3H), 4.01 (s, 3H), 6.68 (s, 1H).

According to the analysis of related databases, 14237-71-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SK CHEMICALS, CO., LTD.; WO2005/63768; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 14237-71-9 , The common heterocyclic compound, 14237-71-9, name is 2-Chloro-4,6-dimethylnicotinonitrile, molecular formula is C8H7ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of the corresponding chloroderivatives (pyridine, pyridazine, coumarin, and nicotinic acid)(10 mmol), selenium metal (1 g, 12 mmol) and sodium borohydride (1.2 g, 32 mmol) in EtOH (50 mL) were stirred till colorless. After that, DMF (20 mL) was added then deep red browncolor appeared. An additional selenium metal (1 g, 12 mmol)was added with EtOH (5 mL). The reaction mixture was reuxedfor 3 hrs., then cooled and poured in ice/HCl. The solid thus separated out was fltered, dried, and recrystallized from ethanol.2,2-Bis(3-cyano-4,6-dimethyl)dipyridyldiselenide (5a): mp244-245C. Data is in agreement with literature survey.20

The synthetic route of 14237-71-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Abdel-Hafez, Shams H.; Abdelwahab, Ahmed B.; Kirsch, Gilbert; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 192; 10; (2017); p. 1114 – 1118;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem