Related Products of 14254-57-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 14254-57-0, name is Isonicotinoyl chloride. A new synthetic method of this compound is introduced below.
General procedure: Compound 14 was prepared from 2f and isonicotinoyl chloride in a similar manner to that described for the synthesis of compound 3 and obtained in 28% yield as a white solid. M.p. 225-227 C. 1H NMR (400 MHz, DMSO-d6, T = 90 C) delta 0.59 (brs, 3H), 0.78 (brs, 4H), 1.40-1.59 (m, 2H), 2.24-2.36 (m, 1H), 2.63 (dt, J = 13.3, 6.8 Hz, 1H), 3.00 (s, 3H), 3.50 (dd, J = 12.5, 7.1 Hz, 1H), 4.23-4.36 (m, 1H), 6.76 (brs, 1H), 6.98-7.10 (m, 2H), 7.26 (brs, 2H), 8.58 (brs, 2H), 10.29 (brs, 1H). 13C NMR (151 MHz, DMSO-d6) delta 20.4, 23.5, 24.9, 33.0, 45.4, 50.8, 51.5, 57.4, 70.4 (d, JC-F = 1.1 Hz, 1C), 109.1 (d, JC-F = 7.7 Hz, 1C), 111.6 (d, JC-F = 24.9 Hz, 1C), 115.4 (d, JC-F = 23.2 Hz, 1C), 120.9 (s, 2C), 128.4 (d, JC-F = 7.7 Hz, 1C), 138.8 (s, 1C), 143.2 (s, 1C), 150.2 (2C) 157.6 (d, JC-F = 236.6 Hz, 1C), 165.7, 168.6, 175.0. MS m/z 426 (M+H)+. Anal. Calcd for C23H24FN3O4¡¤0.1H2O: C, 64.66; H, 5.71; N, 9.83. Found: C, 64.40; H, 5.80; N, 9.84.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,14254-57-0, Isonicotinoyl chloride, and friends who are interested can also refer to it.
Reference:
Article in Press; Ito, Masahiro; Iwatani, Misa; Yamamoto, Takeshi; Tanaka, Toshio; Kawamoto, Tomohiro; Morishita, Daisuke; Nakanishi, Atsushi; Maezaki, Hironobu; Bioorganic and Medicinal Chemistry; (2017);,
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