Category: 14294-11-2

Adding a certain compound to certain chemical reactions, such as: 14294-11-2, 1-(Pyridin-2-yl)thiourea, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 1-(Pyridin-2-yl)thiourea, blongs to pyridine-derivatives compound. name: 1-(Pyridin-2-yl)thiourea

General procedure: Arylthiourea 2 (1 mmol) was added to a solution (in case of 1a) or suspension (for 1b,c) of 3-substituted 1,2,4-triazine 1 (1 mmol) in acetic anhydride. The reaction mixture was stirred at room temperature for 7-27 h. The precipitate obtained was filtered and washed with a small amount of acetic anhydride, diethyl ether and dried in air. For the analytical data, see Online Supplementary Materials.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,14294-11-2, 1-(Pyridin-2-yl)thiourea, and friends who are interested can also refer to it.

Reference:
Article; Mochulskaya, Nataliya N.; Slepukhin, Pavel A.; Charushin, Valery N.; Kodess, Mikhail I.; Mendeleev Communications; vol. 26; 5; (2016); p. 375 – 377;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 14294-11-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14294-11-2, name is 1-(Pyridin-2-yl)thiourea, molecular formula is C6H7N3S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

N-Pyridin-2-ylthiourea 51b (5 g; 35.9 mmol) and 2-(3-bromo-2-oxopropyl)-1H-isoindole-1,3 (2H)-dione (9.1 g; 32.26 mmol) were stirred in 500 ml of THF at RT for 2 h. The precipitate which had formed was filtered off and dried. 12.3 g of white solid; ESI-MS [M+H+]=337.05.

According to the analysis of related databases, 14294-11-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Abbott GmbH & Co. KG; US7105508; (2006); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 14294-11-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14294-11-2, name is 1-(Pyridin-2-yl)thiourea, molecular formula is C6H7N3S, molecular weight is 153.21, as common compound, the synthetic route is as follows.

General procedure: Arylthiourea 2 (1 mmol) was added to a solution (in case of 1a) or suspension (for 1b,c) of 3-substituted 1,2,4-triazine 1 (1 mmol) in acetic anhydride. The reaction mixture was stirred at room temperature for 7-27 h. The precipitate obtained was filtered and washed with a small amount of acetic anhydride, diethyl ether and dried in air. For the analytical data, see Online Supplementary Materials.

The chemical industry reduces the impact on the environment during synthesis 14294-11-2, I believe this compound will play a more active role in future production and life.

Reference:
Article; Mochulskaya, Nataliya N.; Slepukhin, Pavel A.; Charushin, Valery N.; Kodess, Mikhail I.; Mendeleev Communications; vol. 26; 5; (2016); p. 375 – 377;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 14294-11-2 ,Some common heterocyclic compound, 14294-11-2, molecular formula is C6H7N3S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Analogously to Example 1, but using pyridyl-thiourea in place of 2-imino-4-thiobiuret, there is obtained ethyl 2-(pyridin-2-ylamino)-thiazole-4-carboxylate; MS: 250 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14294-11-2, its application will become more common.

Reference:
Patent; Hoffman-La Roche Inc.; US6100282; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14294-11-2, name is 1-(Pyridin-2-yl)thiourea. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 14294-11-2

According to Scheme 3 Step 4: A solution of 2-bromo-1-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)propan-1-one (23.8 mmol, 7.70 g) and of 1-(pyridin-2-yl)thiourea (26.2 mmol, 4.02 g) in EtOH (200 mL) was stirred under reflux overnight. The reaction was quenched with water (200 mL) and the aqueous phase was extracted with DCM. The organic phase was dried over MgSO4, was filtered and was concentrated to yield a brown solid. The resulting crude product was purified by flash chromatography over silica gel using DCM/AcOEt (98:2) as eluent to yield after evaporation 4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-methyl-N-(pyridin-2-yl)thiazol-2-amine (20.7 mmol, 7.80 g, 87%) as a beige solid.LC (Zorbax SB-C18, 3.5 mum, 4.6×50 mm Column): RT=2.29 min; MS m/z ES+=378.

With the rapid development of chemical substances, we look forward to future research findings about 14294-11-2.

Reference:
Patent; Bolea, Christelle; Calanire, Sylvain; US2010/144756; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem