Category: 143468-13-7

Synthetic Route of 143468-13-7, Adding some certain compound to certain chemical reactions, such as: 143468-13-7, name is 6-Bromo-1H-pyrrolo[2,3-b]pyridine,molecular formula is C7H5BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 143468-13-7.

General procedure: The appropriate heterocycle (1 equiv.) was dissolved in a mixture of DMF and THF (1:1 or 1:1.5 respectively, 0.2 M). The solution was cooled to 0 C and sodium hydride (1.2 or 2.2 equiv.) carefully added portion wise. After approximately 5 min the alkyl halide (1.2 equiv.) was carefully added portion-wise. The reaction mixture was stirred at 0 C or at RT for 15 min. to an hour then heated at 80 C for a period ranging between 30 min to 6 h. The reaction mixture was cooled to 0 C and quenched with water and treated with EtOAc and the organic layer separated. The organic solvent was dried (using either MgSO4, Na2SO4 or a phase separator) and subsequently removed under vacuum. The residue was purified by flash silica column chromatography or reverse phase column chromatography to give the product.

According to the analysis of related databases, 143468-13-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UCB Biopharma SPRL; The designation of the inventor has not yet been filed; (80 pag.)EP3527209; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 143468-13-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.143468-13-7, name is 6-Bromo-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H5BrN2, molecular weight is 197.032, as common compound, the synthetic route is as follows.

Step 1. In a 25 mL round-bottomed flask, 6-bromo-1H-pyrrolo[2,3-b]pyridine (250 mg, 1.27 mmol, Eq: 1.00), TIPS-OTf (972 mg, 860 mul, 3.17 mmol, Eq: 2.5) and DIEA (492 mg, 665 mul, 3.81 mmol, Eq: 3) were combined with dioxane (6.25 ml) to give a light brown solution. The reaction mixture was heated to 55 C. and stirred for 16 h. The reaction mixture was poured into 20 mL EtOAc and extracted with sat NaHCO3 (3×10 mL). The organic layers were dried over MgSO4 and concentrated in vacuo. The crude material was purified by flash chromatography (silica gel, 12 g, 5% to 10% EtOAc in hexanes) to give 6-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine (380 mg, 85%) of colorless oil.

The chemical industry reduces the impact on the environment during synthesis 143468-13-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Billedeau, Roland Joseph; Kondru, Rama K.; Lopez-Tapia, Francisco Javier; Lou, Yan; Owens, Timothy D.; Qian, Yimin; So, Sung-Sau; Thakkar, Kshitij C.; Wanner, Jutta; US2012/295885; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 143468-13-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 143468-13-7, name is 6-Bromo-1H-pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A solution of 6 (1mmol) and 4-nitrophenylchloroformate (1.6mmol) in toluene (18mL, for 7g, h, k, q, r, 8) or CH2Cl2 (18ml for 7j) containing NaOH (3mmol) and a catalytic amount of Bu4NBr (0.05mmol) was heated (40-100C) for 2-7h under a stream of nitrogen. Ethyl acetate was added and the organic phase was washed with water, dried over Na2SO4 and filtered. Following this procedure compounds 7g, h, j, k, q, r, 8 were prepared.

According to the analysis of related databases, 143468-13-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Cincinelli, Raffaella; Musso, Loana; Merlini, Lucio; Giannini, Giuseppe; Vesci, Loredana; Milazzo, Ferdinando M.; Carenini, Nives; Perego, Paola; Penco, Sergio; Artali, Roberto; Zunino, Franco; Pisano, Claudio; Dallavalle, Sabrina; Bioorganic and Medicinal Chemistry; vol. 22; 3; (2014); p. 1089 – 1103;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 143468-13-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 143468-13-7, name is 6-Bromo-1H-pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A solution of 6 (1mmol) and 4-nitrophenylchloroformate (1.6mmol) in toluene (18mL, for 7g, h, k, q, r, 8) or CH2Cl2 (18ml for 7j) containing NaOH (3mmol) and a catalytic amount of Bu4NBr (0.05mmol) was heated (40-100C) for 2-7h under a stream of nitrogen. Ethyl acetate was added and the organic phase was washed with water, dried over Na2SO4 and filtered. Following this procedure compounds 7g, h, j, k, q, r, 8 were prepared.

According to the analysis of related databases, 143468-13-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Cincinelli, Raffaella; Musso, Loana; Merlini, Lucio; Giannini, Giuseppe; Vesci, Loredana; Milazzo, Ferdinando M.; Carenini, Nives; Perego, Paola; Penco, Sergio; Artali, Roberto; Zunino, Franco; Pisano, Claudio; Dallavalle, Sabrina; Bioorganic and Medicinal Chemistry; vol. 22; 3; (2014); p. 1089 – 1103;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

143468-13-7, Name is 6-Bromo-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H5BrN2, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Shiekh, Bilal Ahmad, once mentioned the new application about 143468-13-7, Quality Control of 6-Bromo-1H-pyrrolo[2,3-b]pyridine.

Probing non-covalent interactions of phosphine and arsine derivatives: an energy decomposition analysis using localized molecular orbitals

Ab initio (MP2/aug-cc-pVTZ) and density functional theory (DFT) (B3PW91/aug-cc-pVTZ and B3LYP-D3/Def2-TZVPP) analyses have been carried out to characterize the bonding of phosphine and arsine derivatives i.e., M-RH2-HF (M = As or P, R = furan, pyridine, pyrrole, and thiophene) with hydrogen fluoride (HF). Two minima were found on the potential energy surface (PES) for each complex, one in which HF is forming directly an H-bond with pnicogen while the other one in which HF is interacting with the heterocyclic ring in addition to normal H-bond. The latter one is highly stable with MP2/CBS extrapolated binding energies ranging from -10.67 kcal mol(-1) to -6.33 kcal mol(-1). The interaction energies in these complexes follow the order P-PyrHF > P-ThioHF > P-FuHF > P-PyHF > As-PyrHF > As-ThioHF > As-FuHF > As-PyHF. NBO analysis demonstrated that LPAs/P -> sigma H-F orbital interaction plays a major role in stabilizing these complexes, and the largest charge is transferred in P-type complexes compared with their As-type analogs. The LMO-EDA pointed out that all the partitioning terms are stabilizing in nature with a dominant role carried out by exchange energy while as the repulsion energy is the only term being destabilizing in nature. Many body interaction analysis in ternary complexes M-RH2-(HF)(2), in which the other interaction site of heterocyclic rings (N, O, and S) were used for second H-bonding with another HF molecule, revealed that the second H-bond is destabilizing the pnicogen H-bond and showed negative synergetic effects.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 143468-13-7. The above is the message from the blog manager. Quality Control of 6-Bromo-1H-pyrrolo[2,3-b]pyridine.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 143468-13-7, Name is 6-Bromo-1H-pyrrolo[2,3-b]pyridine, SMILES is BrC1=CC=C2C(=N1)[NH]C=C2, belongs to pyridine-derivatives compound. In a document, author is Lazo, John S., introduce the new discover, Name: 6-Bromo-1H-pyrrolo[2,3-b]pyridine.

Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase

Oncogenic protein tyrosine phosphatases (PTPs) are overexpressed in numerous human cancers but they have been challenging pharmacological targets. The emblematic oncogenic PTP4A tyrosine phosphatase family regulates many fundamental malignant processes. 7-Imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione (JMS-053) is a novel, potent, and selective PTP4A inhibitor but its mechanism of action has not been fully elucidated, nor has the chemotype been fully investigated. Because tyrosine phosphatases are notoriously susceptible to oxidation, we interrogated JMS-053 and three newly synthesized analogs with specific attention on the role of oxidation. JMS-053 and its three analogs were potent in vitro PTP4A3 inhibitors, but 7-imino-5-methyl-2-phenylthieno[3,2-c] pyridine-4,6(5H,7H)-dione (NRT-870-59) appeared unique among the thienopyridinediones with respect to its inhibitory specificity for PTP4A3 versus both a PTP4A3 A111S mutant and an oncogenic dual specificity tyrosine phosphatase, CDC25B. Like JMS-053, NRT-870-59 was a reversible PTP4A3 inhibitor. All of the thienopyridinediones retained cytotoxicity against human ovarian and breast cancer cells grown as pathologically relevant three-dimensional spheroids. Inhibition of cancer cell colony formation by NRT-870-59, like JMS-053, required PTP4A3 expression. JMS-053 failed to generate significant detectable reactive oxygen species in vitro or in cancer cells. Mass spectrometry results indicated no disulfide bond formation or oxidation of the catalytic Cys104 after in vitro incubation of PTP4A3 with JMS-053 or NRT-870-59. Gene expression profiling of cancer cells exposed to JMS-053 phenocopied many of the changes seen with the loss of PTP4A3 and did not indicate oxidative stress. These data demonstrate that PTP4A phosphatases can be selectively targeted with small molecules that lack prominent reactive oxygen species generation and encourage further studies of this chemotype. SIGNIFICANCE STATEMENT Protein tyrosine phosphatases are emerging as important contributors to human cancers. We report on a new class of reversible protein phosphatase small molecule inhibitors that are cytotoxic to human ovarian and breast cancer cells, do not generate significant reactive oxygen species in vitro and in cells, and could be valuable lead molecules for future studies of PTP4A phosphatases.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 143468-13-7 is helpful to your research. Name: 6-Bromo-1H-pyrrolo[2,3-b]pyridine.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Reference of 143468-13-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 143468-13-7, Name is 6-Bromo-1H-pyrrolo[2,3-b]pyridine, SMILES is BrC1=CC=C2C(=N1)[NH]C=C2, belongs to pyridine-derivatives compound. In a article, author is Perez, Natalia Marcomini, introduce new discover of the category.

Probing solvents effects on the absorption spectrum of oxo-centered carbonyl-triruthenium clusters

In this work, we describe a combined experimental and theoretical study focused on the solvatochromic effects of eight different solvents on the UV absorption spectrum of three distinct oxo-centered carbonyl-triruthenium clusters of general formula [Ru3O(CH3COO)(6)(CO)(L)(2)], where L=(1) 2,6-dimethylpyrazine (dmpz), (2) pyridine (py), and (3) 4-aminopyridine (ampy). Due to the nature of the ancillary ligands, the charge transfer (CT) absorption band of each complex have a different shift as the solvent polarity/polarizability increases. These shifts have been rationalized using a combined Density Functional/Time-Dependent Density Functional theory and two popular solvatochromic scales: the Catalan and the Kamlet-Taft models. According to the Kamlet-Taft method, the ability of the solvent to donate a proton in a solvent-solute hydrogen bond is more essential on describing the solvatochromic properties of 3 than 1, being also more relevant than solvent polarity. The employed solvatochromic scales also corroborate the preferential solvation behavior of these complexes. (C) 2020 Elsevier Ltd. All rights reserved.

Reference of 143468-13-7, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 143468-13-7.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is an experimental science, Product Details of 143468-13-7, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 143468-13-7, Name is 6-Bromo-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H5BrN2, belongs to pyridine-derivatives compound. In a document, author is Li, Hui.

Efficient heterogeneous acid synthesis and stability enhancement of UiO-66 impregnated with ammonium sulfate for biodiesel production

Sulfated zirconia is a potential heterogeneous acid in catalyzing esterification for biodiesel production. While the catalytic stability is still a challenge during successive batch experiment due to the serious leaching of active site. To address this defect, UiO-66 and ammonium sulfate were employed to synthesize the high efficient acid catalyst for biodiesel production. Catalyst preparation factors and esterification parameters were further investigated to obtain the optimal conditions. Based on these, this study creatively adopted ‘two-stage calcination’ to enhance the catalytic stability. In order to elucidate impact of the second calcination, catalysts were characterized by X-ray diffraction (XRD), thermogravimetry-differential thermogravimetry (TG-DTG), N-2 absorption-desorption, Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), pyridine absorption-Fourier transform infrared spectroscopy (Py-FTIR), Boehm-titration method, scanning electron microscope (SEM), and energy disperse spectroscopy (EDS). Results indicated that the catalytic activity of catalyst calcined under nitrogen atmosphere (UiO-66/SFN) is higher than that calcined under air atmosphere (UiO-66/SAN). The satisfying oleic acid conversion to biodiesel of 96.2% was achieved by UiO-66/SFN with catalyst amount of 8 wt%, molar ratio of methanol/oleic acid of 8 at 70 degrees C for 2 h. After being secondly calcined at 500 degrees C (UiO-66/SSN), the interaction between sulfate and zirconium was evidently improved and the conversion decrement is reduced by 66.25% compared with UiO-66/SFN within five cycles.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 143468-13-7. Product Details of 143468-13-7.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 143468-13-7, Name is 6-Bromo-1H-pyrrolo[2,3-b]pyridine, SMILES is BrC1=CC=C2C(=N1)[NH]C=C2, belongs to pyridine-derivatives compound. In a document, author is Vyas, Komal M., introduce the new discover, Product Details of 143468-13-7.

In vitro evaluation of cytotoxicity and antimetastatic properties of novel arene ruthenium(II)-tetrazolato compounds on human cancer cell lines

Two new arene ruthenium(II) complexes with chemical formula [Ru-2(eta(6)-p-cymene)(2)(mu-L1)(mu-Cl)Cl-2] [Ru]-1 and [Ru(eta(6)-p-cymene)(L2)Cl-2] [Ru]-2 (L1 = 5-phenyl-2H-tetrazole and L2 = 2-(2H-tetrazol-5-yl)pyridine) were synthesized by the reaction of [{(eta(6)-p-cymene)RuCl2}(2)] with two bidentate ligands L1 and L2. Both the complexes were structurally characterized using single-crystal X-ray diffraction and other analytical techniques. The X-ray crystal structures of both the complexes revealed the coordination of tetrazolate ligands to two Ru(II) centres in bridging mode in [Ru]-1, whereas one Ru(II) centre in [Ru]-2 in chelating fashion, with overall pseudo-octahedral geometry. The resulted complexes were screened for their cytotoxic activity against three different cancer cell lines, HCT116 (colon cancer), HepG2 (liver cancer) and MCF7 (breast cancer) under in vitro conditions. Interestingly, [Ru]-1 showed much higher cytotoxicity with respect to [Ru]-2 against all the screened cancer cell lines and even better than cisplatin. For exploring the mechanism of action of [Ru]-1, reactive oxygen species (ROS) production, alterations in mitochondrial membrane potential and gene expression profiling of apoptosis related genes (Bcl2, caspase-3 and caspase-9) were also evaluated. The cancerous cells treated with [Ru]-1 showed an increase in intracellular ROS levels, disruption of mitochondrial membrane potential, up-regulation of proapoptotic caspase-3 and caspase-9 and down-regulation of antiapoptotic Bcl2. The results concluded that [Ru]-1 induced apoptosis through oxidative stress mediated activation of intrinsic pathway by generating intracellular ROS, loss of MMP and alteration of expression of apoptosis related genes. In addition, antimetastatic activity of [Ru]-1 was observed by wound healing assay showing anti-migratory property. The dual properties, antimetastatic activity and high cytotoxicity make [Ru]-1 potent platform for the development of new anticancer agents.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 143468-13-7 is helpful to your research. Product Details of 143468-13-7.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Reference of 143468-13-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 143468-13-7, Name is 6-Bromo-1H-pyrrolo[2,3-b]pyridine, SMILES is BrC1=CC=C2C(=N1)[NH]C=C2, belongs to pyridine-derivatives compound. In a article, author is Desens, Willi, introduce new discover of the category.

NMR spectroscopic and theoretical studies on the isomerism of 1,5-benzodiazepin-2-one derivatives containing a perfluorinated side chain

The isomerism of 1,5-benzodiazepin-2-ones 3 containing a perfluorinated side chain was investigated by H-1 C-13 N-15 an a F-19 NMR spectroscopy in different solvents. Compounds 3 exist in CDCl3, (D-6)acetone, CD3CN and (D-5)Pyridine solution as one species, whereas in (D-6)DMSO and (D-7)DMF partial (E/Z) isomerisation about the exocyclic C-2=C-3 bond occurs resulting in two isomers. Gibbs free energies (Delta G) and Free activation energies (Delta G(not equal)) were calculated based on BP86 and BP86-SCRF DFT computations. (C) 2019 Elsevier B.V. All rights reserved.

Reference of 143468-13-7, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 143468-13-7.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem