Category: 144584-32-7

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 144584-32-7, name is 3-Bromo-2,4-dichloropyridine, molecular formula is C5H2BrCl2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 3-Bromo-2,4-dichloropyridine

A. Preparation of 1-(3-bromo-4-chloropyridin-2-yl)hydrazine To stirring anhydrous dioxane (30 mL) at room temperature was added anhydrous hydrazine (3.29 mL, 105 mmol), followed by portion-wise addition of solid 3-bromo-2,4-dichloropyridine (2.39 g, 10.53 mmol, prepared as described in M. A. Walters, et al., Synth. Comm., Vol. 22, pp. 2829-2837, 1992). The resulting turbid solution was stirred in a 65 C. oil bath for 2 h. After cooling to room temperature, the reaction mixture was evaporated to dryness under reduced pressure. The resulting residue was triturated with isopropanol (50 mL), in which it was only partially soluble, and the mixture was filtered, collecting the solid. The filtrate was evaporated, and the resulting solid was triturated once again with isopropanol (25 mL) and filtered, collecting the solid. The two crops of solid were combined and dried in a 50 C. vacuum oven to obtain 1.438 g of an off-white solid, which contained about 70% of the title compound 1-(3-bromo-4-chloropyridin-2-yl)hydrazine and about 30% of its regioisomer (1-(3-bromo-2-chloropyridin-4-yl)hydrazine). HPLC/MS: retention time=1.06 min, [M+H]+=221.

With the rapid development of chemical substances, we look forward to future research findings about 144584-32-7.

Reference:
Patent; Sun, Chongqing; Sher, Philip M.; Wu, Gang; Ewing, William R.; Huang, Yanting; Lee, Taekyu; Murugesan, Natesan; Sulsky, Richard B.; US2007/4772; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 144584-32-7, name is 3-Bromo-2,4-dichloropyridine, molecular formula is C5H2BrCl2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 3-Bromo-2,4-dichloropyridine

A. Preparation of 1-(3-bromo-4-chloropyridin-2-yl)hydrazine To stirring anhydrous dioxane (30 mL) at room temperature was added anhydrous hydrazine (3.29 mL, 105 mmol), followed by portion-wise addition of solid 3-bromo-2,4-dichloropyridine (2.39 g, 10.53 mmol, prepared as described in M. A. Walters, et al., Synth. Comm., Vol. 22, pp. 2829-2837, 1992). The resulting turbid solution was stirred in a 65 C. oil bath for 2 h. After cooling to room temperature, the reaction mixture was evaporated to dryness under reduced pressure. The resulting residue was triturated with isopropanol (50 mL), in which it was only partially soluble, and the mixture was filtered, collecting the solid. The filtrate was evaporated, and the resulting solid was triturated once again with isopropanol (25 mL) and filtered, collecting the solid. The two crops of solid were combined and dried in a 50 C. vacuum oven to obtain 1.438 g of an off-white solid, which contained about 70% of the title compound 1-(3-bromo-4-chloropyridin-2-yl)hydrazine and about 30% of its regioisomer (1-(3-bromo-2-chloropyridin-4-yl)hydrazine). HPLC/MS: retention time=1.06 min, [M+H]+=221.

With the rapid development of chemical substances, we look forward to future research findings about 144584-32-7.

Reference:
Patent; Sun, Chongqing; Sher, Philip M.; Wu, Gang; Ewing, William R.; Huang, Yanting; Lee, Taekyu; Murugesan, Natesan; Sulsky, Richard B.; US2007/4772; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 144584-32-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 144584-32-7 as follows.

Example 31 2-Chloro-3-bromo-4-(cis-4-tert-butylcyclohexylamino)pyridine 2.2 g (10 mmol) of 2,4-dichloro-3-bromopyridine, 1.86 g (12 mmol) of cis-4-tert-butylcyclohexylamine and 0.1 g ammonium chloride are warmed at 120 C. for 8 hours in 10 ml of N-methylpyrrolidone. After cooling, saturated aqueous sodium hydrogencarbonate solution is added and the reaction product extracted with ethyl acetate. Purification is carried out by column chromatography. Yield: 1.28 g (37%); RF: 0.41 (diisopropyl ether); 1 H-NMR (CDCl3) delta 7.92 (d, 1H), 6.38 (d, 1H), 5.27 (d, 1H), 3.74 (m, 1H), 1.0-2.0 (m, 9H), 0.89 (s, 9H) ppm

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,144584-32-7, its application will become more common.

Reference:
Patent; Hoechst Schering AgrEvo GmbH; US5877322; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 144584-32-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 144584-32-7 as follows.

Example 31 2-Chloro-3-bromo-4-(cis-4-tert-butylcyclohexylamino)pyridine 2.2 g (10 mmol) of 2,4-dichloro-3-bromopyridine, 1.86 g (12 mmol) of cis-4-tert-butylcyclohexylamine and 0.1 g ammonium chloride are warmed at 120 C. for 8 hours in 10 ml of N-methylpyrrolidone. After cooling, saturated aqueous sodium hydrogencarbonate solution is added and the reaction product extracted with ethyl acetate. Purification is carried out by column chromatography. Yield: 1.28 g (37%); RF: 0.41 (diisopropyl ether); 1 H-NMR (CDCl3) delta 7.92 (d, 1H), 6.38 (d, 1H), 5.27 (d, 1H), 3.74 (m, 1H), 1.0-2.0 (m, 9H), 0.89 (s, 9H) ppm

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,144584-32-7, its application will become more common.

Reference:
Patent; Hoechst Schering AgrEvo GmbH; US5877322; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 144584-32-7 , The common heterocyclic compound, 144584-32-7, name is 3-Bromo-2,4-dichloropyridine, molecular formula is C5H2BrCl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 96 2-Chloro-3-bromo-4-(cis-4-phenylcyclohexylamino)-pyridine 2.27 g (10 mmol) of 2,4-dichloro-3-bromopyridine, 2.6 g (15 mmol) of cis-4-phenylcyclohexylamine and 0.1 g of ammonium chloride are heated at 120 C. for 10 hours in 10 ml of N-methylpyrrolidone. After cooling, saturated sodium hydrogencarbonate solution is added and the reaction product is extracted with ethyl acetate. Purification is carried out by column chromatography. Yield: 1.9 g (52%); m.p. 105 C. 1 H-NMR (CDCl3): delta: 7.96 (d, 1H), 7.18 to 7.36 (m, 5H), 6.42 (d, 1H), 5.36 (d, 1H), 3.85 (m, 1H), 2.65 (m, 1H), 1.5 to 2.2 (m, 8H) ppm.

The synthetic route of 144584-32-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoechst Schering AgrEvo GmbH; US5723450; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem