Synthetic Route of 144657-66-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 144657-66-9, name is tert-Butyl 3-formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate, molecular formula is C13H14N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of tert-butyl 3-formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (420 mg, 1.71 mmol) in ethanol (10 mL) was cooled to 0 C with stirring under nitrogen before sodium borohydride (126.6 mg, 3.35 mmol) was added. The reaction mixture was allowed to warm to rt and stirred for 1.25 h.An aqueous solution of hydrochloric acid (2 M, 4 drops) was added, followed immediately by a saturated solution of sodium bicarbonate (1 mL). The reaction mixture was concentrated in vacuo and the residue partitioned between saturated aqueous sodium bicarbonate solution (50 mL) and ethyl acetate (50 mL). The phases were separated and the aqueous phase further extracted with ethyl acetate (2 x 50 mL). The organic phases were combined, filtered through a cartridgecontaining a hydrophobic frit and the solvent evaporated in vacuo. The residue was dissolved in a1:1 mixture of dichloromethane/methanol (10 mL), concentrated under a stream of nitrogen, anddried in vacuoto give a white solid which was dissolved in dichloromethane (5 mL) and loaded ontoa 25 g SNAP silica cartridge which was purified by flash chromatography, eluting wih a gradient ofSO-100% ethyl acetate in cyclohexane. The required fractions were concentrated in vacuo beforebeing dissolved in a 1:1 mixture of dichloromethane/methanol (10 mL), transferrred to a tarred vial,concentrated under a stream of nitrogen and dried in vacuo to give a white solid; tert-butyl 3- (hydroxymethyl)-1 H-pyrrolo[2,3-b] pyrid me- 1-carboxylate (199.7 mg, 0.80 mmol, 47 % yield).LCMS (2 mm formic) Rt = 0.72 mi m/z= 249 for [MH]
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 144657-66-9, tert-Butyl 3-formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; AYLOTT, Helen Elizabeth; COOPER, Anthony William James; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; HAYHOW, Thomas George Christopher; LINDON, Matthew J; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (308 pag.)WO2017/37116; (2017); A1;,
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