145100-50-1 | Pyridine-derivatives

Sep 2021 News Sources of common compounds: 145100-50-1

At the same time, in my other blogs, there are other synthetic methods of this type of compound,145100-50-1, 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide, and friends who are interested can also refer to it.

Electric Literature of 145100-50-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide. A new synthetic method of this compound is introduced below.

Intermediate 11 (0.15 g, 0.76 mmol) was dissolved in 2.5 mL anhydrousdichloromethane under N2. 0.21 mL (1.22 mmol) of N,NDiisopropylethylaminewas added and stirred for 15 min at roomtemperature. The reaction was cooled to 0 C and 0.33 g (0.91 mmol) 2-pyridyltriflimide was added and the reaction stirred overnight at roomtemperature. At completion extraction was done with dichloromethane(3 × 10 mL) and the organic fractions washed with saturated aqueoussodium chloride before being dried over sodium sulfate and concentratedin vacuo. Purification was done by flash chromatography 95:5(DCM:MeOH) to yield 0.06 g (25%) of the product as a light red oil. TLCeluents used (9:1 Dichloromethane: MeOH). 1H NMR (500 MHz;CDCl3): delta 7.18 (t, J = 7.9 Hz, 1H), 7.12 (d, J = 7.5 Hz, 1H), 7.07 (d,J = 8.0 Hz, 1H), 3.10-3.01 (m, 2H), 2.84 (dd, J = 16.0, 10.6 Hz, 1H),2.77-2.71 (m, 2H), 2.44 (s, 6H), 2.23-2.18 (m, 1H), 1.67-1.62 (m, 1H).13C NMR (400 MHz, CDCl3): delta 148.23, 139.75, 129.72, 129.54, 127.07,123.54, 120.35, 118.54, 117.17, 113.97, 59.95, 41.94, 32.51, 25.20,23.62. Calcd C13H17NO3SF3 for [M + H]+: 324.0881. Found:324.0083.

Reference:
Article; Perry, Charles K.; Casey, Austen B.; Felsing, Daniel E.; Vemula, Rajender; Zaka, Mehreen; Herrington, Noah B.; Cui, Meng; Kellogg, Glen E.; Canal, Clinton E.; Booth, Raymond G.; Bioorganic and Medicinal Chemistry; vol. 28; 3; (2020);,
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Introduction of a new synthetic route about 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145100-50-1, its application will become more common.

Related Products of 145100-50-1 ,Some common heterocyclic compound, 145100-50-1, molecular formula is C7H4F6N2O4S2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step C: Preparation of (1S)-1-(4-fluorophenyl)-3-[(3R,4S)-1-(4-{3-[methyl(methylsulfonyl)-amino]propyl}phenyl)-2-oxo-4-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-3-yl]propyl acetate (i-10b wherein R10=CH3) Guanidine (13 mg, 0.13 mmol) was added to a mixture of the intermediate from Step B (82 mg, 0.13 mmol) and triethylamine (18 muL, 0.13 mmol) in methanol (2 mL). After 3 h, the reaction mixture was quenched with saturated aqueous ammonium chloride and extracted three times with EtOAc. The combined organic extracts were washed with water, brine, dried (Na2SO4) and concentrated in vacuo to afford a clear oil which was dissolved in CH2Cl2 (1.5 mL). Triethylamine (24 mL, 0.17 mmol), DMAP (2.0 mg, 0.016 mmol) and (bis(trifluoromethylsulfonyl)amino)pyridine (77 mg, 0.13 mmol) were added successively to the above solution. After 3 h, the reaction was quenched with 0.5N aq. HCl and extracted three times with EtOAc. The combined organic extracts were washed with water, brine, dried (Na2SO4) and concentrated in vacuo. Purification of the crude residue by flash chromatography on silica gel (gradient elution; 35%-40% EtOAc/hexanes as eluent) afforded the title compound. m/z (ES) 655 (M-OAc)+. 1H-NMR (500 MHz, CDCl3) delta: 7.43 (d, J=8.6 Hz, 1H), 7.32-7.28 (m, 2H), 7.15 (d, J=6.4 Hz, 1H), 7.10 (d, J=8.4 Hz, 1H), 7.04 (t, J=6.5 Hz, 1H), 5.72 (t, 6.6 Hz, 1H), 4.66 (d, J=2.3 Hz, 1H), 3.14 (dt, J=2.6, 6.6 Hz, 2H), 3.08 (dt, J=2.5, 8.2 Hz, 1H), 2.84 (s, 3H), 2.79 (s, 3H), 2.61 (t, 7.7 Hz, 2H), 2.08 (overlapped s, 3H), 2.09-2.04 (m, 2H), 1.93-1.84 (m, 4H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145100-50-1, its application will become more common.

Reference:
Patent; DeVita, Robert J.; Morriello, Gregori J.; Lin, Peter; US2007/78098; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Introduction of a new synthetic route about 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145100-50-1, its application will become more common.

Synthetic Route of 145100-50-1 ,Some common heterocyclic compound, 145100-50-1, molecular formula is C7H4F6N2O4S2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145100-50-1, its application will become more common.

Reference:
Patent; DeVita, Robert J.; Morriello, Gregori J.; Lin, Peter; US2007/78098; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Share a compound : 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide

The synthetic route of 145100-50-1 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide, the common compound, a new synthetic route is introduced below. Formula: C7H4F6N2O4S2

To a solution of the obtained compound (34 mg, 0.08 mmol) in CH2Cl2 (0.8 mL) were added pyridine (15 mg, 0.19 mmol), 2-[N,N-bis(trifluoromethane-sulfonyl) amino]pyridine (34 mg, 0.096 mmol), and DMAP (1 mg) at 0 C. The reaction mixture was stirred at rt for 30 min, and the reaction was stopped by addition of water. The mixture was extracted with CH2Cl2 and the organic layer was washed with water and dried over anhydrous MgSO4. The solvent was concentrated, and the obtained residue was purified by PTLC (AcOEt/hexane = 1:4) to obtain the title compound (37 mg, 83%). 1H NMR (CDCl3) delta: 1.11-1.24 (1H, m), 1.42 (6H, s), 1.43 (3H, s), 1.53 (3H, s), 1.74 (1H, dt, J = 13.7, 3.9 Hz), 1.80-1.93 (1H, m), 2.96 (1H, dt, J = 11.1, 3.6 Hz), 3.59-3.92 (5H, m), 3.98 (2H, s), 7.00-7.03 (2H, m), 7.10-7.35 (6H, m).

The synthetic route of 145100-50-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ohtake, Yoshihito; Sato, Tsutomu; Matsuoka, Hiroharu; Kobayashi, Takamitsu; Nishimoto, Masahiro; Taka, Naoki; Takano, Koji; Yamamoto, Keisuke; Ohmori, Masayuki; Higuchi, Takashi; Murakata, Masatoshi; Morikawa, Kazumi; Shimma, Nobuo; Suzuki, Masayuki; Hagita, Hitoshi; Ozawa, Kazuharu; Yamaguchi, Koji; Kato, Motohiro; Ikeda, Sachiya; Bioorganic and Medicinal Chemistry; vol. 20; 13; (2012); p. 4117 – 4127;,
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Share a compound : 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 145100-50-1, 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide. A new synthetic method of this compound is introduced below., Computed Properties of C7H4F6N2O4S2

EXAMPLE 2This example illustrates a preparation of abiraterone acetate (I) on an industrial scale starting from prasterone acetate (Ill) according to the invention.51 kg of potassium tert-butylate in THF (760 kg) and prasterone acetate (100 kg) are stirred at a temperature below -70 C. Then N-(2-pyridyl)-bis(trifluoromethanesulfonimide) (1 33 kg) is added maintaining the stirring for 2 hours at a temperature between -70 and -80 C.The cold solution is poured onto a biphasic solution consisting of isopropyl acetate(360 kg) and a 10% ammonium chloride aqueous solution.The phases are separated and the organic phase is first washed with an aqueoussolution of ammonium chloride, then with 450 kg 10% sodium acetate aqueoussolution, and eventually with an aqueous solution of sodium chloride.A part of the solvent is distilled off at reduced pressure obtaining the precipitation of a solid which is eliminated by filtration. The residual solution is then distilled until obtaining an oil which is crystallized from the mixture methanol/triethylamine. The sample obtained after drying (112 kg) verified in HPLC (A = 220 nm) against anauthentic sample is intermediate (II) with 98.14% titer.112 kg of intermediate (II) is dissolved in THF (1079 kg), then bis(triphenylphosphinepalladium(l l)dichloride Pd(P Ph3)2C12 (3.2 kg), diethyl(pyridyl)borane (129.3 kg) and an aqueous solution of sodium carbonate are added under stirring at 20-25 00.Reflux is kept for 1 hour (TLC check), further 400 g of bis(triphenylphosphinepalladium(l l)dichloride Pd(PPh3)2C12 is added, obtaining complete transformation (TLC check) after further 30 minutes of reaction. Cooling down to 20-25 C is performed, the phases are separated by washing the organic phase with an aqueous solution of sodium chloride.The organic phase is then distilled until obtaining a dark oil which is then solubilized with methanol, recovering by fractional crystallization the excess diethyl(pyridyl)borane.Methanol is eliminated by distillation, the residue is dissolved in isopropyl acetate, then the solution is filtered after treatment with decolorising carbon and silica gel.The solution, adjusted at T = 20 ± 5 00 is then treated with oxalic acid dihydrate (60 kg).Stirring is performed at T = 20 ± 5 00 for 8 hours and then the solid is filtered and washed with isopropyl acetate.The abiraterone acetate oxalate obtained is stirred at a temperature between 0 and 500 with methylene chloride (880 kg) and an aqueous solution of sodium bicarbonate.The phases are separated and the organic phase is distilled.The solid obtained is dissolved in isopropyl acetate, then treated with Quadrasil(registered trademark of Johnson Matthey Finland Oy) for 6 hours, for the removal of the catalyst; the Quadrasil scavengers, sold by Sigma-Aldrich, consist of porous silica beads having defined pore size, wherein the silica surface is functionalised with metal binders, and allow a quick and effective removal of traces of metals fromaqueous or organic solutions.After filtration, a part of the solvent is distilled off, cooling down to 0 ± 5 00 is performed obtaining the crystallisation of the product.The abiraterone acetate obtained after drying (65 kg) meets the specifications reported in the corresponding chapter of the European Pharmacopoeia.

Reference:
Patent; INDUSTRIALE CHIMICA S.R.L.; LENNA, Roberto; DI BRISCO, Riccardo; WO2015/14686; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Brief introduction of 145100-50-1

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 145100-50-1, 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide.

Related Products of 145100-50-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide, molecular formula is C7H4F6N2O4S2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

At -78C, a solution of tert-butyl 4-oxo-3 ,4-dihydro-2//-spiro[naphthalene- 1 ,4′- piperidine]-l’-carboxylate (Al) (2.66g, 8.44 mmol) in THF (30 ml) was added dropwise to a solution of lithium bis(trimethylsilyl) amide (1.0M in hexane, 10.5 ml, 10.5 mmol) in THF (20 ml). After 30 min at -78C, 2-(N,N-bis(trifluoromethylsulfonyl)amino)-pyridine (3.77g, 10.5 mmol) was added and the reaction mixture was slowly warmed to 00C (ca. 2h), poured into ice, extracted with ether, and purified by flash chromatography on silica gel(hexane/dichloromethane 8:2) to give tert-butyl 4-(trifluoromethylsulfonyloxy)-2H- spiro[naphthalene-l,4′-piperidine]-l’-carboxylate (A2). LC-MS: m/e = 391.9 (M + H – C(CH3)3). Rt= 4.19 min. 1H-NMR (500MHz, DMSO-d6): 7.50 (d, IH)3 7.40 (t, IH), 7.30 (t, IH), 6.16 (t, IH), 3.83 (br.d, 2H), 3.05 (br. s, 2H), 2.67 (d, 2H), 1.72 – 1.67 (m, 4H), 1.41 (s, 9H). [00147] A mixture of the triflate (A2) (447 mg, lmmol), sodium cyanide (lOOmg, 2 mmol), copper (I) iodide (19 mg, 0.1 mmol) and tetrakis(triphenylphosphine)palladium(0) (58 mg, 0.05 mmol) in acetonitrile (10 ml) was degassed and heated under reflux under nitrogen for 4h. After concentration, the residue was directly purified by flash chromatography (hexane/EtOAc 8:2) to give tert-butyl 4-cyano-2H-spiro[naphthalene-l,4′-piperidine]-r-carboxylate (A3) (300 mg). LC-MS: m/e = 269.0 (M + H – C(CH3)3. 3.75 min. 1H-NMR (500MHz5 DMSOd6): 7.49 (d, 1 H), 7.42 – 7.36 (m, 3H), 7.09 (t, IH), 3.81 (br. d, 2 H), 3.03 (br. s, 2H), 2.67 (d, 2H), 1.70 (td, 2H), 1.62 (d, 2H), 1.41 (s, 9H),[00148] A solution of the m’trile (A3) (300 mg) in dichloromethane (3 ml) was treated with TFA (1 ml) for 1 hour, concentrated, co-evaporated with acetonitrile and dissolved in dichloromethane (ca. 100ml). The resulting solution was washed with a mixture of brine (ca. 20 ml) and 6N NaOH (2 ml), dried over Na2SO4, and concentrated to give 2H-spiro[naphthalene- l,4′-piperidine]-4-carbonitrile (A4) as a white solid. LC-MS: m/e = 225.2 (M + H). R,= 1.53 min.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2008/5295; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New learning discoveries about 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide

The synthetic route of 145100-50-1 has been constantly updated, and we look forward to future research findings.

EXAMPLE 14B 1-tert-butyl-3-methyl 4-{[(trifluoromethyl)sulfonyl]oxy}-5,6-dihydropyridine-1,3(2H)-dicarboxylate A solution of Example 14A (958 mg, 3.73 mmol) in dichloromethane (10 mL) at 0 C. was treated with diisopropylethylamine (2 mL) and 2-[N,N-bis(trifluoromethylsulfonyl)amino]pyridine (2.67 g, 7.46 mmol), warmed to room tempeature overnight, treated with additional diisopropylethylamine (2 mL) and 2-[N,N-bis(trifluoromethylsulfonyl)amino]pyridine (2.67 g, 7.46 mmol), stirred for 5 days, and partitioned between ethyl acetate and saturated sodium bicarbonate. The organic layer was washed with brine, dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 5 to 10% ethyl acetate/hexanes to provide the desired product (1.02 g, 70%). MS (DCI/NH3) m/e 407 (M+NH4)+; 1H NMR (300 MHz, CDCl3) delta4.27 (m, 2H), 3.84 (s, 3H), 3.63 (t, J=5.8 Hz, 2H), 2.52 (m, 2H), 1.48 (s, 9H).

The synthetic route of 145100-50-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Gwaltney II, Stephen L.; Nelson, Lissa T.J.; O’Connor, Stephen J.; Sham, Hing L.; Sullivan, Gerard M.; Wang, Weibo; US2003/216441; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some tips on 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide

The chemical industry reduces the impact on the environment during synthesis 145100-50-1, I believe this compound will play a more active role in future production and life.

Synthetic Route of 145100-50-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide, molecular formula is C7H4F6N2O4S2, molecular weight is 358.24, as common compound, the synthetic route is as follows.

General procedure: To a mixture of bis(3,5-bis(trifluoromethyl)phenyl)(2,5-dihydroxyphenyl)phosphineoxide (25) (291 mg, 0.500 mmol) and N-(2-pyridyl)bis(trifluoromethanesulfonimide)(358 mg, 1.00 mmol) dissolved in CH2Cl2 (5.0 mL) was added triethylamine (0.174 mL,1.25 mmol) at room temperature. After stirring for 16 h at the same temperature, to the mixture was added an aqueous saturated solution of NH4Cl (5 mL). The mixture was extracted with CH2Cl2 (10 mL × 3), and the combined organic extract was dried (Na2SO4), and after filtration, the filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica-gel 30 g, n-hexane/EtOAc= 8/2) to give bis(3,5-bis(trifluoromethyl)phenyl)(2,5-bis(triflyloxy)phenyl)phosphineoxide (1g) (399 mg, 0.471 mmol, 94.3%) as a colorless solid.

The chemical industry reduces the impact on the environment during synthesis 145100-50-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Nishiyama, Yoshitake; Kamada, Shuhei; Yoshida, Suguru; Hosoya, Takamitsu; Chemistry Letters; vol. 47; 9; (2018); p. 1216 – 1219;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Brief introduction of 145100-50-1

With the rapid development of chemical substances, we look forward to future research findings about 145100-50-1.

A common compound: 145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide,molecular formula is C7H4F6N2O4S2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 145100-50-1

(1R)-3-bromo-2-trifluoromethylsulfoxy-1,7,7-trimethyl-bicyclo[2.2.1]heptene-2; [] To the solution of (1R)-3-bromocamphor (46.22g; 0.2 mol) in 230 ml THF 2M LDA solution (105 ml, 0.21 mol) was added drop wise at -78 C. After 30 min stirring at the same temperature a solution of 2-[N,N-bis(trifluoromethane sulfonyl)amino]pyridine (75.23g; 0.21 mol) in 80 ml of THF was added drop wise and then allowed to warm to room temperature over night. Then reaction mixture was cooled in ice bath and 250 ml of ice cold water was carefully added and product was extracted with ether (8 x 50 ml). The combined organic layers were washed with ice cold 2N NaOH, followed with brine, and dried over MgSO4/K2CO3. The residue after concentration on rotary evaporator was dissolved in 200 ml of hexane and filtered trough a shot pad of basic Al2O3. Filtrate was concentrated on rotary evaporator and the resulting oil was distilled in vacuum to give 64 g (88 %) of product as colorless oil (b.p. 73-76C/0.5 mbar).1H NMR (CDCl3) delta = 0.74 (s, 3H), 0.93 (s, 3H), 1.03 (s, 3H), 1.23 (ddd, J=12.6, J=9.2, J=3.7, 1H), 1.43 (ddd,J=12.4, J=8.9, J=3.4, 1H), 1.62 (ddd, J=12.4, J=8.5 J=3.9, 1H), 1.87 (ddt, J=12.5, J=8.6, J=3.7, 1H), 2.46 (d, J=3.7, 1H); 13C NMR (CDCl3) delta = 9.95, 18.71, 19.36, 24.96, 32.05, 56.16, 56.87, 58.72, 113.28, 118.43 (q, J=320.3), 151.99.

With the rapid development of chemical substances, we look forward to future research findings about 145100-50-1.

Reference:
Patent; Degussa AG; EP1595888; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Brief introduction of 145100-50-1

145100-50-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of phenol, obtained as above, dissolved in CH2Cl2 (30 mL) were addedN-(2-pyridyl)bis(trifluoromethanesulfonimide) (1.83 g, 5.12 mmol) and triethylamine(1.07 mL, 7.65 mmol) at room temperature. After stirring for 6 h at the same temperature,to the mixture was added an aqueous saturated solution of NH4Cl (30 mL). The mixture was extracted with CH2Cl2 (50 mL ¡Á 3), and the combined organic extract was dried (Na2SO4), and after filtration, the filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica-gel 100 g, n-hexane/CH2Cl2= 4/6 to 1/9) to give bis(3,5-bis(trifluoromethyl)phenyl)(2-triflyloxyphenyl)phosphineoxide (1c) (2.27 g, 3.25 mmol, 63.7% in two steps) as a colorless solid.