145255-19-2 | Page 2 of 2 | Pyridine-derivatives

Extended knowledge of 145255-19-2

At the same time, in my other blogs, there are other synthetic methods of this type of compound,145255-19-2, 5-Aminopyridine-2-carboxamide, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 145255-19-2, 5-Aminopyridine-2-carboxamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Aminopyridine-2-carboxamide, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Aminopyridine-2-carboxamide

EXAMPLE 238: 4-[4-(6-CarbamoyIpyridin-3-ylamino)-7No.-pyrrolo[2,3-rf]pyriraidin-6-yl]-3,6-dihydro-2JHr-pyridme-l-carboxylic acid tert-butyl ester; .NH2^»[673] Into the DMF (ImL) solution of 4-(4-chloro-7No.-pyrrolo[2,3-J]pyrimidin-6-yl)-3,6-dihydro-2/ir-pyridine-l-carboxylic acid tert-butyl ester (122mg, 0.363mmol) wasadded t-BuOK (1M in ^-BuOH, 0.726mL, 0.726mmol) dropwise at RT under N2 over 5min.The mixture was then put in an ice/water bath and stirred for lOmin. After that time, theDMF (ImL) solution of 5-aminopyridine-2-carboxylic acid amide (99.5mg, 0.726mmol) wasadded into the above mixture dropwise. The reaction mixture was warmed to RT.Pd2(dba)3-CHCl3 (9.4mg, 2.5%eq.) and^(+)-BINAP (22.6mg, O.leq.) were added, and themixture was heated at 100C for 24h. The mixture was filtered and the filtrate wasconcentrated in vacua. The crude was submitted to MS directed purification. A brown oilwas obtained that was purified further by HPLC to obtain the title compound as an off-whitesolid. ‘H NMR (DMSO-dft 400 MHz): 5 = 1.50 (s, 9 H), 2.50 (m, 2 H), 3.64 (t, 2 H, J= 5.6Hz), 4.12 (bra, 2 H), 6.50 (bra, 1 H), 6.88 (s, 1 H), 7.53 (d, 1 H, J= 4.2 Hz), 8.04 – 8.05 (m, 1H), 8.08 (d, 1 H, J= 8.8 Hz), 8.44 (s, 1 H), 8.68 (dd, 1 H, /= 2.4 & 8.4 Hz), 9.12 (d, 1 H, J=2.4 Hz), 9.91 (s, 1 H), 12.18 (s, 1 H). MS (ES+): m/z 436.10 (100) [MET]. HPLC: fe = 2.75min (ZQ2000, polar_5 min).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,145255-19-2, 5-Aminopyridine-2-carboxamide, and friends who are interested can also refer to it.

Reference:
Patent; OSI PHARMACEUTICALS, INC.; WO2006/17443; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extracurricular laboratory: Synthetic route of 145255-19-2

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 145255-19-2, 5-Aminopyridine-2-carboxamide.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 145255-19-2, name is 5-Aminopyridine-2-carboxamide. A new synthetic method of this compound is introduced below., Quality Control of 5-Aminopyridine-2-carboxamide

[1140] 60mg (0.129 mmol, 89% purity) of 2-[4-(5-chloro- 2-cyanophenyl)-5-methoxy-2-oxopyridin- 1 (2H)-yl]-3-(3- methyl-i ,2-oxazol-5-yl)propanoic acid (racemate) and 27 mg (0.194 mmol, 1.5 eq.) of 5-aminopyridine-2-carboxam- ide were initially charged in 1.0 ml of pyridine, 123 jil (0.516 mmol, 50% in ethyl acetate, 4.0 eq.) of T3P were added and the mixture was stirred at 50 C. for 2 h. The reaction mixture was cooled, 4 ml of water and 4 ml of saturated aqueous sodium hydrogencarbonate solution were added and the mixture was stirred for 10 mm. The suspension was filtered with suction and washed with water and three times with 2 ml each time of acetonitrile, and then the filtrate was lyophilized Yield: 51 mg (73% of theory).j1141] LCMS [Method 1]: R=0.83 mm; MS (ESIpos):m1z533 (M+H), j1142] ?H-NMR (400 MHz, DMSO-d5): oe [ppm]=i0.94(s, 1H), 8.84 (d, 1H), 8.22 (dd, 1 H), 8.07-8.01 (m, 2 H), 7.99 (d, 1H), 7.75-7.68 (m, 2H), 7.58-7.50 (m, 2H), 6.52 (s, 1H), 6.03 (s, 1H), 5.99 (dd, 1H), 3.88 (dd, 1H), 3.74-3.63 (m, 4H),2.14 (s, 3H)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 145255-19-2, 5-Aminopyridine-2-carboxamide.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ROeHRIG, Susanne; JIMENEZ-NUNEZ, Eloisa; SCHLEMMER, Karl-Heinz; TERSTEEGEN, Adrian; TELLER, Henrik; HILLISCH, Alexander; HEITMEIER, Stefan; SCHMIDT, Martina Victoria; ACKERSTAFF, Jens; STAMPFUss, Jan; (87 pag.)US2017/291892; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of 5-Aminopyridine-2-carboxamide

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145255-19-2, its application will become more common.

Electric Literature of 145255-19-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 145255-19-2 as follows.

[1144] 40 mg (0.098 mmol) of 2-[4-(5-chioro-2-cyano- phenyl)-5-methoxy-2-oxopyridin-i (2H)-yl] -3-(i ,3-oxazol- 2-yl)propanoic acid (racemate) and 20mg (0.147 mmol, 1.5 eq.) of 5-aminopyridine-2-carboxamide were initially charged in 0.8 ml of pyridine, 93 j±1 (0.392 mmol, 50% in ethyl acetate, 4.0 eq.) of T3P were added and the mixture was stirred at 50 C. for 2 h. The reaction mixture was cooled, 6 ml of saturated aqueous sodium hydrogencarbonate solution were added and the mixture was stirred for 15 mm. The crystals formed were filtered oil with suction and washed with water, 500 j±1 of isopropanol and then pentane. The residue was dried under high vacuum. Yield: 29 mg (57% of theory).11145] LCMS [Method 1]: R=0.79 mm; MS (ESIpos):mlz=5 19 (M+H), j1146] ?H-NMR (400 MHz, DMSO-d5): oe [ppm]=i0.91(s, 1H), 8.84 (d, 1H), 8.20 (dd, 1H), 8.07-7.95 (m, 4H), 7.73 (dd, 1H), 7.68 (d, 1H), 7.52 (s, 2H), 7.12 (s, 1H), 6.51 (s, 1H), 6.00 (t, 1H), 3.78 (d, 2H), 3.64 (s, 3H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145255-19-2, its application will become more common.

A new synthetic route of 5-Aminopyridine-2-carboxamide

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145255-19-2, its application will become more common.

The origin of a common compound about 5-Aminopyridine-2-carboxamide

With the rapid development of chemical substances, we look forward to future research findings about 145255-19-2.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 145255-19-2, name is 5-Aminopyridine-2-carboxamide. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 5-Aminopyridine-2-carboxamide

2-Chloro-3-fluoro-6-[2-methoxy-4-(trifluoromethoxy)phenoxy]benzoyl chloride was dissolved in THF (2 mL) and cooled to 0 C. DIEA (138 mu, 0.792 mmol) and 5-aminopyridine-2- carboxamide (40 mg, 0.29 mmol) were added and the resulting suspension was stirred at 0 C for 30 minutes and then allowed to warmed to room temperature and stirred for 16 hours. The reaction mixture was diluted with ethyl acetate and washed with water and brine. The organic later was separated, dried by passing through a phase separation cartridge and concentrated in vacuo. Silica gel chromatography (0- 100% ethyl acetate/petroleum ether) provided 5-[[2-chloro-3-fluoro-6-[2-methoxy-4- (trifluoromethoxy)phenoxy]benzoyl]amino]pyridine-2-carboxamide (85 mg, 64%). ESI-MS m/z calc. 499.06, found 500.0 (M+l)+;497.9 (M-l)-; retention time (Method E): 3.01 minutes (5 minute run). NMR (400 MHz, DMSO-d6) delta 11.25 (s, 1H), 8.86 (d, J = 2.4 Hz, 1H), 8.28 (dd, J = 8.6, 2.5 Hz, 1H), 8.09 – 7.99 (m, 2H), 7.56 (s, 1H), 7.49 (t, J = 9.0 Hz, 1H), 7.23 – 7.16 (m, 2H), 6.98 (ddd, J = 8.9, 2.8, 1.3 Hz, 1H), 6.84 (dd, J = 9.3, 3.9 Hz, 1H), 3.77 (s, 3H) ppm.

With the rapid development of chemical substances, we look forward to future research findings about 145255-19-2.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; AHMAD, Nadia; ANDERSON, Corey; ARUMUGAM, Vijayalaksmi; ASGIAN, Iuliana, Luci; CAMP, Joanne, Louise; FANNING, Lev Tyler, Dewey; HADIDA RUAH, Sara, Sabina; HURLEY, Dennis; SCHMIDT, Yvonne; SHAW, David; SHETH, Urvi, Jagdishbhai; THOMSON, Stephen, Andrew; (691 pag.)WO2019/14352; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extended knowledge of 5-Aminopyridine-2-carboxamide

According to the analysis of related databases, 145255-19-2, the application of this compound in the production field has become more and more popular.

Application of 145255-19-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 145255-19-2, name is 5-Aminopyridine-2-carboxamide, molecular formula is C6H7N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of 5-aminopyridine-2-carboxamide (248.6 mg, 1.813 mmol) in dichloromethane (2.50 mL) and N,N-diisopropylethylamine (420 mu, 2.41 mmol) was cooled to 0 C. A solution of ice cold 2-fluoro-6-[2-(trideuteriomethoxy)-4-(trifluoromethoxy)phenoxy]-3-(trifluoromethyl)benzoyl chloride in dichloromethane (2.5 inL) was added slowly dropwise to the stirring amine solution. The mixture was removed from the ice bath after 1 hour and stirred at RT for 69 hours. The reaction was diluted with dichloromethane and washed with water, 1 N HCl, saturated aqueous sodium bicarbonate and brine. The organic layer was dried over Na2S04, filtered and the solvent was evaporated under reduced pressure. The crude material was purified by silica gel chromatography (ethyl acetate/hexane gradient) to yield 5 – [[2-fluoro-6- [2-(trideuteriomethoxy)-4-(trifluoromethoxy)phenoxy] -3 – (trifluoromethyl)benzoyl]amino]pyridine-2-carboxamide (326 mg, 51%) as a white solid. ESI-MS m/z calc. 536.10, found 537.0 (M+l)+; retention time (Method C): 2.48 minutes (5 minute run). ‘H NMR (400 MHz, DMSO-d6) delta 11.36 (s, 1H), 8.88 (d, J = 2.5 Hz, 1H), 8.31 (dd, J = 8.6, 2.5 Hz, 1H), 8.07 (d, J = 8.6 Hz, 1H), 8.03 (d, J = 2.8 Hz, 1H), 7.81 (t, J = 8.6 Hz, 1H), 7.57 (d, J = 2.8 Hz, 1H), 7.37 (d, J = 8.7 Hz, 1H), 7.25 (d, J = 2.8 Hz, 1H), 7.12 – 6.92 (m, 1H), 6.69 (d, J = 8.9 Hz, 1H) ppm.

According to the analysis of related databases, 145255-19-2, the application of this compound in the production field has become more and more popular.