Category: 146679-66-5

Reference of 146679-66-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.146679-66-5, name is 3-Bromo-4-pyridinemethanol, molecular formula is C6H6BrNO, molecular weight is 188.02, as common compound, the synthetic route is as follows.

To a solution of 3bromo-4-(hydroxymethyl)pyridine 4 (1.593 g, 8.47 mmol) in dichioromethane (20 mL) was added imidazole (0.692 g, 10.17 mmol) and tert-butyldimethylsilyl chloride (1.534 g, 10.17 mmol) at 0C and the reaction mixture was stirred for 18 h at ft. The solution was extractedwith DCM and the organic phase was washed with brine, dried and concentrated under vacuum. Purification by silica gel column chromatography using EtOAc/DCM (1/9) as eluent gave j (2.518 g, 98 %).?H NMR (CDC13, 300 MHz, 298 K, 6 ppm): 8.60 (s, 1 H), 8.52 (d, IH, J 4.8 Hz), 7.52 (d, 1H, J= 4.8 Hz), 4.71 (s, 2 H), 0.97 (s, 9 H), 0.15 (s, 6H).13C NMR (CDC13, 75.5 MHz, 298K, 8 ppm): 150.90, 149.67, 148.54, 122.19, 119.20, 63.78, 25.96,18,43, 5.31.GC/MS (m/z): [M-t-Butyl] 244. IR (KBr, v, cm?): 3046, 2953, 2887, 2857, 2709, 1926, 1789, 1737, 1587, 1472, 1445, 1397, 1373, 1360, 1261, 1172, 1114, 1079, 839, 778, 706, 673.

The chemical industry reduces the impact on the environment during synthesis 146679-66-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; INSA (INSTITUT NATIONAL DES SCIENCES APPLIQUEES) DE ROUEN; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE ROUEN; VFP THERAPIES; MARSAIS, Francis; LEVACHER, Vincent; PAPAMICAEL, Cyril; BOHN, Pierre; PEAUGER, Ludovic; GEMBUS, Vincent; LE FUR, Nicolas; DUMARTIN-LEPINE, Marie-Laurence; WO2014/114742; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 146679-66-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.146679-66-5, name is 3-Bromo-4-pyridinemethanol, molecular formula is C6H6BrNO, molecular weight is 188.02, as common compound, the synthetic route is as follows.

Step 2 ;To a mixture of (3-bromopyridin-4-yl)methanol (150 mg, 0.8 mmol, 1 eq.), 1-isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (226 mg, 0.96 mmol, 1.2 eq.), Pd(dppf)Cl2 (58 mg, 0.08 mmol, 0.1 eq.), and K2CO3 (331 mg, 3.0 mmol, 3 eq.) in a RB flask were added dioxane (6 mL) and water (2 mL). The mixture was heated at 100 C. for 2 h, cooled, filtered, and concentrated. The crude was purified on silica gel using a mixture of EtOAc and hexanes as eluent to give (3-(1-isopropyl-1H-pyrazol-5-yl)pyridin-4-yl)methanol (75 mg, 43%) as a yellow oil. LRMS (M+H+) m/z 218.1.

Statistics shows that 146679-66-5 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-4-pyridinemethanol.

Reference:
Patent; Global Blood Therapeutics, Inc.; The Regents of the University of Califorina; Cytokinetics, Inc.; Metcalf, Brian; Chuang, Chihyuan; Warrington, Jeffrey; Paulvannan, Kumar; Jacobson, Matthew P.; Hua, Lan; Morgan, Bradley; US2015/344483; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem