Category: 147149-98-2

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.147149-98-2, name is 4-Amino-2-(trifluoromethyl)pyridine, molecular formula is C6H5F3N2, molecular weight is 162.11, as common compound, the synthetic route is as follows.Formula: C6H5F3N2

1,3-cyclopentanedione (3.3 g, 33.9 mmol) and 4-amino-2-trifluoromethylpyridine (5.0 g, 30.8 mmol) are suspended in acetic acid (15 mL) and shaken at 130 C under microwave irradiation overnight. The reaction mixture is diluted with water and purified by reversed phase HPLC. Yield: 4.17 g; ESI mass spectrum [M+H]+=243; Retention time HPLC: 0.77 min (method Z018_S04).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,147149-98-2, 4-Amino-2-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; Boehringer Ingelheim International GmbH; PETERS, Stefan; ANDERSKEWITZ, Ralf; GNAMM, Christian; HOESCH, Holger; MORSCHHAEUSER, Gerd; OOST, Thorsten; RIES, Uwe Joerg; (84 pag.)US2016/31830; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 147149-98-2, 4-Amino-2-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 147149-98-2, blongs to pyridine-derivatives compound. Product Details of 147149-98-2

2-Trifluoromethyl-4-aminopyridine (1.123 kg, 6.92 mol) was added to a 30 L reactor.2-methyltetrahydrofuran (31.82kg),2,4-Dichloro-6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine (1.857 kg, 6.30 mol),Turn on the agitation,Nitrogen protection,Slowly added N,N-diisopropylethylamine (1.220 kg, 9.44 mol);After heating and refluxing for 30 minutes, the heating was turned off and naturally cooled for 2 hours.After the reaction was completely monitored by HPLC, the mixture was cooled to room temperature, diluted with ethyl acetate (18.00 kg), and poured into a 0.5 mol/L hydrochloric acid solution (15.00 kg) to maintain the internal temperature below 25 C and stirred.Liquid separation,The organic phase was washed twice with 0.25-0.35 mol/L hydrochloric acid solution (10.00 kg).Wash with saturated brine, dry over anhydrous sodium sulfate, and filter.Organic phase concentrationThe title compound was 2.070kg,The yield was 78.2%.

The synthetic route of 147149-98-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Shenghe Pharmaceutical Co., Ltd.; Zhao Liwen; Zhang Jin; Chen Cheng; Xu Chenglong; Wang Cheng; (19 pag.)CN110054616; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.147149-98-2, name is 4-Amino-2-(trifluoromethyl)pyridine, molecular formula is C6H5F3N2, molecular weight is 162.11, as common compound, the synthetic route is as follows.SDS of cas: 147149-98-2

To a solution of 2,4-dichloro-6-(4- (trifluoromethyl)pyrimidin-2-yl)-l,3,5-triazine (981 mg, 3.31 mmol) in THF (80 mL) was added 2-(trifluoromethyl)pyridin-4-amine (590 mg, 3.64 mmol) and NaHC03 (556 mg, 6.6 mmol). The mixture was stirred at refluxing for 18 hours. The mixture was concentrated and poured to water, extracted with ethyl acetate, dried over sodium sulphate, filtered and concentrated to give a residue, which was purified by Si02 chromatography to give 4-chloro-6-(4-trifluoromethyl- pyrimidin-2-yl)-[l,3,5]triazin-2-yl]-(2-trifluoromethyl-pyridin-4-yl)-amine. LCMS: m/z 422.2 (M+H)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,147149-98-2, 4-Amino-2-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; TRAVINS, Jeremy; UTLEY, Luke; WO2015/6592; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 147149-98-2, name is 4-Amino-2-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 147149-98-2

POCl3 (98.85 mg, 0.65 mmol) was added to a mixture of 1-(2-methylimidazo[1,2-a]pyridin-5-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (100 mg, 0.32 mmol), 2-(trifluoromethyl)pyridin-4-amine (52.26 mg, 0.32 mmol), pyridine (127.49 mg, 1.61 mmol) in CH2Cl2 (3 mL) at rt. The reaction mixture was stirred at room temperature for 1 h. The reaction mixture was quenched with 20 mL sat. K2CO3 aq, and extracted with CH2Cl2 (20 mL*3). The organic layer was separated and concentrated under reduced pressure. It was purified by preparative high-performance liquid chromatography (35% to 65% (v/v) CH3CN and H2O with 0.05% ammonia hydroxide). The pure fractions were collected and the organic solvent was concentrated under reduced pressure. The aqueous layer was lyophilized to dryness to give the desired product as a white solid. (80 mg, purity: 99.5%, yield: 54.3%). LCMS (ESI) m/z M+1: 454.9. 1H NMR (400 MHz, DMSO-d6) delta ppm 2.32 (s, 3H), 7.08 (s, 1H), 7.32 (d, J=7.06 Hz, 1H), 7.41 (dd, J=9.04, 7.28 Hz, 1H), 7.75 (d, J=9.04 Hz, 1H), 7.94 (dd, J=5.73, 1.76 Hz, 1H), 8.21 (d, J=1.76 Hz, 1H), 8.65 (s, 1H), 8.69 (d, J=5.29 Hz, 1H), 11.29 (s, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 147149-98-2, 4-Amino-2-(trifluoromethyl)pyridine.

Reference:
Patent; Janssen Biotech, Inc.; Lu, Tianbao; Allison, Brett Douglas; Barbay, Joseph Kent; Connolly, Peter J.; Cummings, Maxwell David; Diels, Gaston; Edwards, James Patrick; Kreutter, Kevin D.; Philippar, Ulrike; Shen, Fang; Thuring, Johannes Wilhelmus John Fitzgerald; Wu, Tongfei; (412 pag.)US2018/170909; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 147149-98-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 147149-98-2, name is 4-Amino-2-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

4) Methyl 2-methyl-2-[3-(2-trifluoromethylpyridin-4-yl)ureido]propionate 65.6 3.8 ml of a solution of phosgene in toluene (20%) were initially charged under argon. At 75 C., 0.58 g of compound 65.5 dissolved in 20 ml of dry acetonitrile was slowly added dropwise; the mixture was then stirred at 80 C. for 4 h. The mixture was repeatedly concentrated with toluene under reduced pressure. The residue was dissolved in 20 ml of dry tetrahydrofuran and admixed with 0.55 g of methyl amino-isobutyrate hydrochloride. 0.76 ml of triethylamine was slowly added dropwise to this mixture which was then stirred at room temperature for 4 h and then left to stand overnight. The reaction mixture was admixed with water and extracted with ethyl acetate. The organic phase was dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by chromatography on silica gel with 95/5 dichloromethane/methanol. The urea 65.6 was obtained in 59% yield. Molecular weight 305.09 (C12H14F3N3O3); retention time Rt=1.66 min. [B]; MS (ESI): 306.44 (MH+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 147149-98-2, 4-Amino-2-(trifluoromethyl)pyridine.

Reference:
Patent; SANOFI-AVENTIS; US2009/215728; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem