Category: 1480-64-4

Application of 1480-64-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1480-64-4, name is 3-Chloro-2-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows.

3-Chloro-2-fluoropyridine (5.00 g, 37.25 mmol, 1 eq.) and benzylamine (5.75 mL, 52.15 mmol, 1.4 eq.) were addedto cesium carbonate (18.21 g, 55.88 mmol, 1.5 eq.) in dimethyl sulfoxide (25 mL) and the reaction mixture wasstirred at 105 C for 7 h. After cooling to 25 C water (25 mL) was added dropwise using an ice bath to maintain thetemperature below 30C. The reaction mixture was transferred to a separation funnel. Then water (15 mL) andethyl acetate (40 mL) were added and the phases were separated. The aqueous phase was extracted with ethylacetate (2 x 50 mL). The combined organic phases were washed with water (4 x 50 mL) and brine (50 mL). Dryingover magnesium sulfate, removal of the solvent and purification by flash chromatography (2 to 3% ethyl acetate inheptanes) gave the N-benzyl-3-chloropyridin-2-amine as a white solid (6.56 g, 81%). Rf = 0.25 (5% ethyl acetate inheptanes).1H NMR (400 MHz, CDCl3): = 1H NMR (400 MHz, CDCl3): = 4.71 (d, J = 5.5 Hz, 2 H), 5.28 (br. s, 1 H), 6.57 (dd, J =7.8, 5.0 Hz, 1 H), 7.27 – 7.32 (m, 1 H), 7.33 – 7.42 (m, 4 H), 7.46 -7.51 (obs. m, 1 H), 8.07 (dd, J = 4.9, 1.6 Hz, 1 H).13C NMR (101 MHz, CDCl3): = 45.5, 113.1, 115.4, 127.3, 127.7, 128.6, 136.1, 139.3, 146.0, 153.9.LC/MS (m/z): [M + H]+ calculated for C12H12ClN2+, 219.1 ; found, 218.7

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1480-64-4, 3-Chloro-2-fluoropyridine.

Reference:
Article; De Gasparo, Raoul; Lustenberger, Philipp; Mathes, Christian; Schlama, Thierry; Veitch, Gemma E.; Le Paih, Jacques J. M.; Synlett; vol. 26; 2; (2015); p. 197 – 200;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1480-64-4, name is 3-Chloro-2-fluoropyridine, the common compound, a new synthetic route is introduced below. Quality Control of 3-Chloro-2-fluoropyridine

3-Chloro-2-fluoropyridine (5.00 g, 37.25 mmol, 1 eq.) and benzylamine (5.75 mL, 52.15 mmol, 1.4 eq.) were addedto cesium carbonate (18.21 g, 55.88 mmol, 1.5 eq.) in dimethyl sulfoxide (25 mL) and the reaction mixture wasstirred at 105 C for 7 h. After cooling to 25 C water (25 mL) was added dropwise using an ice bath to maintain thetemperature below 30C. The reaction mixture was transferred to a separation funnel. Then water (15 mL) andethyl acetate (40 mL) were added and the phases were separated. The aqueous phase was extracted with ethylacetate (2 x 50 mL). The combined organic phases were washed with water (4 x 50 mL) and brine (50 mL). Dryingover magnesium sulfate, removal of the solvent and purification by flash chromatography (2 to 3% ethyl acetate inheptanes) gave the N-benzyl-3-chloropyridin-2-amine as a white solid (6.56 g, 81%). Rf = 0.25 (5% ethyl acetate inheptanes).1H NMR (400 MHz, CDCl3): = 1H NMR (400 MHz, CDCl3): = 4.71 (d, J = 5.5 Hz, 2 H), 5.28 (br. s, 1 H), 6.57 (dd, J =7.8, 5.0 Hz, 1 H), 7.27 – 7.32 (m, 1 H), 7.33 – 7.42 (m, 4 H), 7.46 -7.51 (obs. m, 1 H), 8.07 (dd, J = 4.9, 1.6 Hz, 1 H).13C NMR (101 MHz, CDCl3): = 45.5, 113.1, 115.4, 127.3, 127.7, 128.6, 136.1, 139.3, 146.0, 153.9.LC/MS (m/z): [M + H]+ calculated for C12H12ClN2+, 219.1 ; found, 218.7

The synthetic route of 1480-64-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; De Gasparo, Raoul; Lustenberger, Philipp; Mathes, Christian; Schlama, Thierry; Veitch, Gemma E.; Le Paih, Jacques J. M.; Synlett; vol. 25; 9; (2014);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1480-64-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1480-64-4, name is 3-Chloro-2-fluoropyridine, molecular formula is C5H3ClFN, molecular weight is 131.54, as common compound, the synthetic route is as follows.

Example 97 (4S,6S)-4-(5-((3-chloropyridin-2-yl)oxy)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine The title compound was synthesized using steps and procedures analogous to those described in Method M (Example 92) above, but using 3-chloro-2-fluoropyridine (Matrix) in step 5. MS m/z=422 [M]+. Calculated for C17H13ClF5N3O2: 421.75. 1H NMR (300 MHz, CHLOROFORM-d) ppm 2.19 (t, J=13.15 Hz, 1H) 2.69 (d, J=13.74 Hz, 1H) 4.18 (d, J=8.92 Hz, 3H) 4.34-4.58 (m, 1H) 4.61-4.86 (m, 1H) 6.98 (dd, J=7.38, 4.90 Hz, 1H) 7.12 (d, J=8.62 Hz, 2H) 7.30 (d, J=7.31 Hz, 2H) 7.76 (d, J=7.60 Hz, 1H) 8.00 (d, J=4.82 Hz, 1H).

The chemical industry reduces the impact on the environment during synthesis 1480-64-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MINATTI, Ana Elena; LOW, Jonathan D.; ALLEN, Jennifer R.; CHEN, Jian; CHEN, Ning; CHENG, Yuan; JUDD, Ted; LIU, Qingyian; LOPEZ, Patricia; QIAN, Wenyuan; RUMFELT, Shannon; RZASA, Robert M.; TAMAYO, Nuria A.; XUE, Qiufen; YANG, Bryant; ZHONG, Wenge; US2014/249104; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem