As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 148639-07-0, name is 2-Chloro-3-fluoro-4-iodopyridine, molecular formula is C5H2ClFIN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 148639-07-0
A mixture of 2-chloro-3-fluoro-4- iodopyridine (4.78 g, 18.6 mmol), 2-chloro-6-nitrobenzamide (3.91 g, 19.5 mmol), ethane- 1,2-diamine (0.2 mL, 2.97 mmol), copper(I) iodide (0.57 g, 2.97 mmol) and K3P04 (7.90 g, 37.2 mmol) in dioxane (80 mL), was degassed with a stream of argon and the reaction mixture was then heated under reflux for 4 hours. After cooling to room temperature, the crude reaction mixture was filtered through Celite washing with dioxane. The filtrate was concentrated to dryness under reduced pressure and the resultant residue was purified by column chromatography on silica gel eluting with 0-100% ethyl acetate in petroleum ether (40-60 C), to afford the title compound as a pale yellow solid (1.87 g, 31% yield). ¾ NMR (400 MHz, DMSO-i/6): delta 11.42-11.37 (br s, 1H), 8.35-8.24 (m, 3H), 8.08 (dd, J = 1.1, 8.1 Hz, 1H), 7.81 (t, J= 8.2 Hz, 1H).
With the rapid development of chemical substances, we look forward to future research findings about 148639-07-0.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; ELLWOOD, Charles; GOODACRE, Simon; LAI, Yingjie; LIANG, Jun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong; WO2012/35039; (2012); A1;,
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