Category: 149142-67-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 149142-67-6, name is 5-Bromo-1H-pyrrolo[2,3-b]pyridine-2,3-dione. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 149142-67-6

General procedure: A mixture of 1 (0.4 mmol), 2 (0.4 mmol), Na2CO3 (0.8 mmol) and TBHP (0.4 mmol) in DMF (4 mL) was stirred at rt for 2 h. Then, the mixture was poured into ice-water, acidified with 1 N HCl aq. (6 mL). The mixture was extracted with ethyl acetate (20 mL x 3). The combined organic layer was dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by silica gel flash column chromatography to give desired products..

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Reference:
Article; Wu, Jun; Zhang, Hui; Ding, Xiao; Tan, Xuefei; Shen, Hong C.; Chen, Jie; He, Weimin; Deng, Hongmei; Song, Liping; Cao, Weiguo; Journal of Fluorine Chemistry; vol. 220; (2019); p. 54 – 60;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 149142-67-6, name is 5-Bromo-1H-pyrrolo[2,3-b]pyridine-2,3-dione. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H3BrN2O2

An appropriate amount of 1.82 g (10 mmol) of 5-chloro-7-N erythropoose was dissolved in 50 mL of ethanol, placed in a Erlenmeyer flask,Was slowly added dropwise to 50 mL of an ethanol solution containing 0.75 g (15 mmol) of hydrazine hydrate and heated to 80 C for 6 hours. Thin layerChromatography method to track the reaction to complete, the reaction system of the mixture before the hot filter, washed with ethanol, the filtrate was static crystallizationIntermediates. The resulting intermediate was placed in a reactor with 2.26 g (10 mmol) of 5-bromo-7-Nindalene, 50 mL of ethanol was added,Heated and stirred, and refluxed at 80 C for 4 hours. TCL tracking to the reaction is complete, stop heating, remove the condensing device. Will reactThe solid-liquid mixture of the system was concentrated under reduced pressure, cooled to room temperature and filtered. The filter cake was washed with warm water to give 5-chloro-5′-bromo-Double 7-N hetero-aldehyde Schiff base (2) crude. The crude product was added to the reactor, and 25 mL of ethanol was added for recrystallization,Dried to give a yellowish brown color crystalline powder (3.11 g) in a total yield of 76.9%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 149142-67-6, 5-Bromo-1H-pyrrolo[2,3-b]pyridine-2,3-dione.

Reference:
Patent; Shaanxi University of Science and Technology; Liang Chengyuan; Jia Minyi; Tian Danni; Ju Weihui; Pei Shaomeng; (17 pag.)CN106632407; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem